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Recombinant Rat Casp8 protein, His & T7-tagged

Cat.No. : Casp8-7832R
Product Overview : Recombinant Rat Casp8 aa. (Tyr8~Val197 (Accession# Q9JHX4)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : Member of the cysteine-aspartic acid protease (caspase) familythat mediates the terminal stage of apoptosis; involved in apoptosis induced by Fas and other stimuli.
Source : E. coli
Species : Rat
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 25.8kDa
Protein length : Tyr8~Val197 (Accession# Q9JHX4)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.1.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Casp8 caspase 8 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Casp8
Synonyms : Casp8; caspase 8; CASP-8; caspase-8
Gene ID : 64044
mRNA Refseq : NM_022277.1
Protein Refseq : NP_071613.1
UniProt ID : Q9JHX4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to study the regulatory mechanism of CASP8 protein? 11/28/2022

Studying the regulatory mechanism of CASP8 protein requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.

What are the mutation types of CASP8 protein? 08/06/2022

The mutation types of CASP8 protein include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the relationship between CASP8 protein and other genes or proteins? 06/07/2022

CASP8 protein has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of CASP8 protein in apoptosis? 06/05/2021

CASP8 protein plays a key role in apoptosis, and its activation can activate downstream effector molecules to trigger programmed cell death.

How to detect and analyze mutations in CASP8 protein? 02/22/2021

Mutations in the CASP8 protein can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to treat diseases by regulating the level of CASP8 protein? 12/11/2019

By regulating the level of CASP8 protein, some diseases related to apoptosis can be treated, such as by inhibiting its activity or regulating its expression.

Customer Reviews (3)

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Reviews
04/01/2022

    CASP8 is highly stable.

    03/21/2022

      The reduction of the synthesis cost of this protein leads to the increase of the application.

      04/02/2021

        CASP8 has a high specificity.

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