|Official Full Name||core-binding factor, runt domain, alpha subunit 2; translocated to, 3|
|Background||This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.|
|Synonyms||CBFA2T3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; protein CBFA2T3; MTG16; MTGR2; myeloid translocation gene 8 and 16b; ZMYND4; MTG8-related gene 2; MTG8-related protein 2; zinc finger MYND domain-containing protein 4; myeloid|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CBFA2T3 involved in several pathways and played different roles in them. We selected most pathways CBFA2T3 participated on our site, such as ErbB4 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBFA2T3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ErbB4 signaling events||CBFA2T3; WWOX; WWP1; YAP1|
CBFA2T3 has several biochemical functions, for example, chromatin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBFA2T3 itself. We selected most functions CBFA2T3 had, and list some proteins which have the same functions with CBFA2T3. You can find most of the proteins on our site.
|chromatin binding||FLI1; HESX1; SMARCD3; EZH1; WDR82; MITF; ERCC6; TP73; GLI3; HMGB3|
|metal ion binding||AMPD2; TNNI1; SUMF1; ZEB2; ZNF224; GMEB1; RUFY4; ZNF707; AGBL4; CYP8B2|
|protein binding||VEGFAA; ARRB1; WARS; PICK1; FAM212A; HSPA5; TRAF7; RUVBL1; AAGAB; JRK|
|transcription corepressor activity||SP100; HSBP1; LIMD1; BCOR; CDX2; TGIF1; CTCF; SMYD1; NPAT; MAP3K10|
|transcription factor activity, sequence-specific DNA binding||FOXS1; ZNF174; ATF7B; HOXB3; TAF4B; ZNF501; ZNF615; ELK4; TBX16; TA|
CBFA2T3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBFA2T3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBFA2T3.
PLXNA3; ZNF652; Prkar1a; ZBTB47; MATN2; SEC24A; ATN1; cotE; uup3; GMEB2; TRIM33