Recombinant Human CBFA2T3 Protein, GST-Tagged

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Recombinant Human CBFA2T3 Protein, GST-Tagged

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Cat.No. : CBFA2T3-0453H
Product Overview : Human CBFA2T3 full-length ORF (AAH62624.1, 1 a.a. - 615 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 93.3 kDa
AA Sequence : MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH TLMNGSSHSP TAINGAPCTP NGFSNGPATS STASLSTQHL PPACGARQLS KLKRFLTTLQ QFGSDISPEI GERVRTLVLG LVNSTLTIEE FHSKLQEATN FPLRPFVIPF LKANLPLLQR ELLHCARLAK QTPAQYLAQH EQLLLDASAS SPIDSSELLL EVNENGKRRT PDRTKENGSD RDPLHPQRYS PSNGPPQPTP PPHYRLEDIA MAHHFRDAYR HPDPRELRER HRPLVVPGSR QEEVIDHKLT EREWAEEWKH LNNLLNCIMD MVEKTRRSLT VLRRCQEADR EELNHWARRY SDAEDTKKGP APAAARPRSS SAGPEGPQLD VPREFLPRTL TGYVPEDIWR KAEEAVNEVK RQAMSELQKA VSDAERKAHE LITTERAKME RALAEAKRQA SEDALTVINQ QEDSSESCWN CGRKASETCS GCNAARYCGS FCQHRDWEKH HHVCGQSLQG PTAVVADPVP GPPEAAHSLG PSLPVGAASP SEAGSAGPSR PGSPSPPGPL DTVPR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 [ Homo sapiens ]
Official Symbol : CBFA2T3
Synonyms : CBFA2T3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; protein CBFA2T3; MTG16; MTGR2; myeloid translocation gene 8 and 16b; ZMYND4; MTG8-related gene 2; MTG8-related protein 2; zinc finger MYND domain-containing protein 4; myeloid translocation gene on chromosome 16 protein; ETO2;
Gene ID : 863
mRNA Refseq : NM_005187
Protein Refseq : NP_005178
MIM : 603870
UniProt ID : O75081

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