Recombinant Human CBFA2T3 Protein, GST-Tagged

• Cat.No.: CBFA2T3-0453H
• Product Overview: Human CBFA2T3 full-length ORF (AAH62624.1, 1 a.a. - 615 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 93.3 kDa
• AA Sequence: MPASRLRDRAASSASGSTCGSMSQT HPVLESGLLASAGCSAPRGPRKGGP APVDRKAKASAMPDSPAEVKTQPRS TPPSMPPPPPAASQGATRPPSFTPH TLMNGSSHSPTAINGAPCTPNGFSN GPATSSTASLSTQHLPPACGARQLS KLKRFLTTLQQFGSDISPEIGERVR TLVLGLVNSTLTIEEFHSKLQEATN FPLRPFVIPFLKANLPLLQRELLHC ARLAKQTPAQYLAQHEQLLLDASAS SPIDSSELLLEVNENGKRRTPDRTK ENGSDRDPLHPQRYSPSNGPPQPTP PPHYRLEDIAMAHHFRDAYRHPDPR ELRERHRPLVVPGSRQEEVIDHKLT EREWAEEWKHLNNLLNCIMDMVEKT RRSLTVLRRCQEADREELNHWARRY SDAEDTKKGPAPAAARPRSSSAGPE GPQLDVPREFLPRTLTGYVPEDIWR KAEEAVNEVKRQAMSELQKAVSDAE RKAHELITTERAKMERALAEAKRQA SEDALTVINQQEDSSESCWNCGRKA SETCSGCNAARYCGSFCQHRDWEKH HHVCGQSLQGPTAVVADPVPGPPEA AHSLGPSLPVGAASPSEAGSAGPSR PGSPSPPGPLDTVPR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 [ Homo sapiens ]
• Official Symbol: CBFA2T3
• Synonyms: CBFA2T3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; protein CBFA2T3; MTG16; MTGR2; myeloid translocation gene 8 and 16b; ZMYND4; MTG8-related gene 2; MTG8-related protein 2; zinc finger MYND domain-containing protein 4; myeloid translocation gene on chromosome 16 protein; ETO2
• Gene ID: 863
• mRNA Refseq: NM_005187
• Protein Refseq: NP_005178
• MIM: 603870
• UniProt ID: O75081