CBX8 Protein, chromobox homolog 8

CBX8

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CBX8

Official Full Name chromobox homolog 8
Background The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules,Which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin.
Synonyms CBX8; chromobox homolog 8; chromobox homolog 8 (Drosophila Pc class); chromobox protein homolog 8; HPC3; Pc class 3 homolog (Drosophila); PC3; polycomb 3; RC1; rectachrome 1; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila)
    • Species :
    • Human
    • Source :
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CBX8-0486H Recombinant Human CBX8 Protein, GST-Tagged Wheat Germ GST
    Human CBX8-7800HCL Recombinant Human CBX8 293 Cell Lysate HEK293 N/A

    CBX8 involved in several pathways and played different roles in them. We selected most pathways CBX8 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular Senescence CDKN2A; SUZ12; ASF1A; CDK4; CDKN2B; BMI1B; HIST4H4; CDKN2D; RAD50; HIST1H1D
    Cellular responses to stress H3F3B.1; RBB4L; HIF3A; TXN2; HIST1H1B; HIST4H4; CDKN2D; DYNLL2A; DNAJC7; UVRAG
    Metabolism of proteins PIGK; HSCB; CALCA; TIMM50; MTX1; CTSH; ARSJ; CGB7; TRAPPC6A; PHC3
    Oxidative Stress Induced Senescence RNF2; CBX6A; SCMH1; RING1; PHC2; PHC1; SUZ12B; CBX8; CBX6; EED
    Post-translational protein modification ADAMTS18; ARSK; DPAGT1; MUC21; DPH3; SPON1; MUC1; GALNTL2; ADAMTS15; ARSD
    SUMO E3 ligases SUMOylate target proteins NSMCE1; NSMCE4A; SMC5; RNF2; PHC2; SCMH1; NSMCE2; RING1; SMC6; EID3
    SUMOylation SMC6; SMC5; CBX8; NSMCE2; PHC1; SENP1; UBA2; PHC3; NSMCE4A; PHC2
    SUMOylation of DNA damage response and repair proteins PHC3; NSMCE2; EID3; PHC2; CBX8; SMC5; NSMCE4A; NSMCE1; PHC1; SCMH1

    CBX8 has several biochemical functions, for example, methylated histone binding, protein binding, single-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX8 itself. We selected most functions CBX8 had, and list some proteins which have the same functions with CBX8. You can find most of the proteins on our site.

    Function Related Protein
    methylated histone binding CDYL2; GLYR1; LOXL2; CBX7; DPPA3; MSL3; UHRF1; CBX4; KDM4A; KAT8
    protein binding KCNJ5; DOK3; CTBP1; RTP4; C1QTNF6; SHARPIN; NLRX1; MTMR4; PSMA7; MYZAP
    single-stranded RNA binding CNBP; ZFP36; AGO1; RBMX; POLR2GL; TLR7; DHX58; DLX2; CBX4; CBX7
    ubiquitin-protein transferase activator activity UBE2L3; AUP1; FBXW7; CBX8; RING1

    CBX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX8.

    BMI1; RNF2

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