ccdc6
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  • Official Full Name
  • coiled-coil domain containing 6
  • Background
  • This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.
  • Synonyms
  • CCDC6; coiled-coil domain containing 6; D10S170, DNA segment on chromosome 10 (unique) 170 , TST1; coiled-coil domain-containing protein 6; DNA segment; single copy; probe pH4 (transforming sequence; thyroid 1; H4; PTC; TPC; papillary thyroid carcinoma-e
Cat.#:CCDC6-0563HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCDC6 Protein, GST-Tagged
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Cat.#:CCDC6-2909MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCDC6 Protein
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Cat.#:CCDC6-2883CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCDC6
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Cat.#:CCDC6-297HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCDC6 cell lysate
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Involved Pathway

CCDC6 involved in several pathways and played different roles in them. We selected most pathways CCDC6 participated on our site, such as Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCDC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
STK4; EGLN1; PIAS2; RAF1; WNT5A; ARHGEF1; FGFR3; PTGER4; Shh; ERBB2
Thyroid cancer
RXRB; LEF1; TPM3; RET; CCDC6; MAP2K1; TFG; NTRK1; PAX8; TCF7

Protein Function

CCDC6 has several biochemical functions, for example, SH3 domain binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by CCDC6 itself. We selected most functions CCDC6 had, and list some proteins which have the same functions with CCDC6. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein DOCK1; PTPN12; CRB3; SH2D2A; NOXA1; ADAM19; ADAM15; INPPL1B; PDCD6IP; USP8
Function protein binding
Related Protein HIPK1; PYROXD1; MEP1B; LAMP1; STOML1; FH; RPS6KA3; SPAG9; NUS1; SILV
Function structural constituent of cytoskeleton
Related Protein NEFH; TUBB5; TUBB; TUBA1B; TUBB2; DMD; TUBA1A; TUBA8L4; SPTB; ADD3

Interacting Protein

CCDC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCDC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCDC6.
PPP4C; FBXW7; saicar; PKM; CSNK2A1; USP7; ESR1; P4HB; BMH1; PPP2R1A

CCDC6 Related Articles

Werner-Peterson, R; Sloboda, RD; et al. Methylation of Structural Components of the Axoneme Occurs During Flagellar Disassembly. BIOCHEMISTRY 52:8501-8509(2013).
Tang, XQ; Diao, J; et al. Identification of a 37.6 kDa membrane protein from flounder gill cells involved in binding and infection to lymphocystis disease virus. AQUACULTURE 358:132-138(2012).