CFH
-
Official Full Name
complement factor H
-
Overview
Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces. -
Synonyms
CFH; complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000033598; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; isoform b ag; e-related maculopathy susceptibility 1; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; age-related maculopathy susceptibility 1;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293F
- Human Cell
- Human Serum
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse
- Wheat Germ
- C
- His
- GST
- hFc
- His (Fc)
- Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CFH-23H | Active Native Human Complement factor H | Human Serum | N/A | ||
Human | CFH-115H | Active Native Human Factor H | Human Serum | N/A | ||
Human | CFH-26763TH | Recombinant Human CFH, His-tagged | E.coli | His | ||
Human | CFH-3183H | Recombinant Human CFH, His tagged | Human Cell | His | ||
Human | CFH-641H | Recombinant Human CFH protein, His-tagged | E.coli | His | Ser860~Arg1231 | |
Human | CFH-1168H | Recombinant Human CFH Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CFH-2409HCL | Recombinant Human CFH cell lysate | Human Cell | N/A | ||
Human | CFH-762H | Recombinant Human CFH Protein, His-tagged | HEK293F | N-His | Gly1107-Arg1231 | |
Human | CFH-3295HF | Recombinant Full Length Human CFH Protein, GST-tagged | In Vitro Cell Free System | GST | 449 amino acids | |
Human | CFH-763H | Recombinant Human CFH Protein, His-tagged | E.coli | N-His | Glu19-Leu322 | |
Human | CFH-1048H | Recombinant Human CFH Protein (Glu19-Pro346), N-His tagged | E.coli | N-His | Glu19-Pro346 | |
Human | DMABT-H19244 | Mouse Anti-CFH Monoclonal Antibody | Mouse | N/A | ||
Human | CAB11509MH | Mouse Anti-Human Complement Factor H Monoclonal Antibody | Mouse | N/A | ||
Human | CFH-1180H | Recombinant Human CFH Protein (Glu19-Leu449), C-His tagged | Mammalian cells | C-His | Glu19-Leu449 | |
Mouse | Cfh-626M | Active Recombinant Mouse Cfh Protein, His-tagged | Mammalian cells | His | Ser875-Val1252 | |
Mouse | Cfh-396M | Recombinant Mouse Cfh protein, hFc-tagged | HEK293 | hFc | Ser875-Val1252 | |
Mouse | Cfh-392M | Recombinant Mouse Cfh protein, His-tagged | HEK293 | His | Ser875-Val1252 | |
Mouse | Cfh-642M | Recombinant Mouse Cfh protein, His & T7-tagged | E.coli | His/T7 | Glu915~Thr1156 (Accession # P06909) | |
Mouse | Cfh-1612M-B | Recombinant Mouse Cfh Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Cfh-761M | Recombinant Mouse Cfh Protein, His-tagged | E.coli | N-His | Ser877-Val1234 | |
Mouse | Cfh-1612M | Recombinant Mouse Cfh Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Cfh-643R | Recombinant Rat Cfh protein, His-tagged | E.coli | His | Ala975~Ser1217 (Accession # G3V9R2) | |
Cattle | CFH-640C | Recombinant Cattle CFH protein, His & T7-tagged | E.coli | His/T7 | Gly879~Gly1236 (Accession# Q28085) | |
Zebrafish | CFH-7847Z | Recombinant Zebrafish CFH | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CFH Related Articles
- CFH Related Research Area
CFH involved in several pathways and played different roles in them. We selected most pathways CFH participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Complement and coagulation cascades | Serpina1c;BDKRB1;F13B;SERPIND1;CD46;PLG;C5;SERPINA1D;GM5077 |
Staphylococcus aureus infection | C1QB;C1R;SELP;FCGR1A;FCGR4;ITGB2L;SELPLG;ICAM1;H2-AB1 |
CFH has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFH itself. We selected most functions CFH had, and list some proteins which have the same functions with CFH. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
heparan sulfate proteoglycan binding | GPC6;AZU1;Gpc2;HPSE2;GPC1B;GPC3;FST;ITGAM;UBE4A |
heparin binding | APLP1;PTPRFB;PDCD5;LPL;FGF9;APP;BSPH1;FGFR1;HRG |
protein binding | ZNF664-FAM101A;CDK20;BCKDHA;DCTN4;WBSCR27;CROP;TUFM;DMC1;ZNF193 |
CFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFH here. Most of them are supplied by our site. Hope this information will be useful for your research of CFH.
C3; C3; ennX; TFAP2A; VDR; GRB2; SMAD3; ZBTB16; EP300; q81p70_bacan; colA; TFAP2C; YTHDC1; q99ib8-pro_0000045596; d-mannose; ALB
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in CFH increase the risk of aHUS, affecting complement regulation and leading to kidney damage.
CFH controls the complement system, preventing its overactivation and protecting against immune damage.
CFH modulates the immune response to bacterial infections, balancing defense mechanisms.
CFH deficiency is linked to AMD, due to impaired regulation of the complement pathway in the retina.
CFH shields host cells from complement-mediated injury, maintaining tissue integrity.
CFH regulates inflammation and maintains immune balance, crucial for preventing excessive immune responses.
Changes in CFH function can impact kidney health, potentially leading to renal diseases due to altered complement activity.
Customer Reviews (3)
Write a reviewExceptional protein expression optimization support, highly appreciated assistance.
Precise protein quantification, ensures data accuracy in our research.
Timely antibody validation, an invaluable asset for our laboratory.
Ask a Question for All CFH Products
Required fields are marked with *
My Review for All CFH Products
Required fields are marked with *