• Official Full Name
  • complement factor H
  • Background
  • Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
  • Synonyms
  • CFH; complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000033598; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; isoform b ag; e-related maculopathy susceptibility 1; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; age-related maculopathy susceptibility 1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CFH Protein, GST-Tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFH, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CFH, His tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFH protein, His-tagged
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cfh protein, His-tagged
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cfh protein, Fc-tagged
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Cfh Protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cfh protein, His & T7-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cfh protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CFH
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CFH protein, His & T7-tagged
Source (Host):Human SerumSpecies:Human
Product nameNative Human Factor H
Source (Host):Human SerumSpecies:Human
Product nameNative Human Complement factor H
Source (Host):HEK293Species:Human
Product nameRecombinant Human CFH cell lysate

Involved Pathway

CFH involved in several pathways and played different roles in them. We selected most pathways CFH participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
Staphylococcus aureus infection
ITGB2; FGG; FCGR3A; Hc; C3; FPR1; FCGR4; cgr2b; FCGR2C; SELP

Protein Function

CFH has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFH itself. We selected most functions CFH had, and list some proteins which have the same functions with CFH. You can find most of the proteins on our site.
Related Protein
Function heparan sulfate proteoglycan binding
Related Protein FST; GPC5A; GPC3; SLIT2; GPC1; GPC5; ITGAM; GPC6; Itgam&Itgb2; GPC4
Function heparin binding
Related Protein LXN; ELANE; GPNMB; LIPG; LIPH; BMP4; Epy; FN1; FGF14; ADAMTSL5
Function protein binding
Related Protein PIP5K1A; LGI4; ECH1; TCF12; PLCG2; TBATA; H2AFX; GFM1; MPP5; PRSS2

Interacting Protein

CFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFH here. Most of them are supplied by our site. Hope this information will be useful for your research of CFH.
C3; C3; ennX; TFAP2A; VDR; GRB2; SMAD3; ZBTB16; EP300; q81p70_bacan; colA; TFAP2C; YTHDC1; q99ib8-pro_0000045596; d-mannose; ALB

CFH Related Articles

Cortina, G; Trojer, R; et al. De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. PEDIATRIC NEPHROLOGY 30:693-697(2015).
Khandelwal, P; Gupta, A; et al. Effect of plasma exchange and immunosuppressive medications on antibody titers and outcome in anti-complement factor H antibody-associated hemolytic uremic syndrome. PEDIATRIC NEPHROLOGY 30:451-457(2015).