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CFH

  • Official Full Name

    complement factor H

  • Overview

    Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
  • Synonyms

    CFH; complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000033598; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; isoform b ag; e-related maculopathy susceptibility 1; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; age-related maculopathy susceptibility 1;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Human Serum
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • C
  • His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CFH-23H Active Native Human Complement factor H Human Serum N/A
Human CFH-115H Active Native Human Factor H Human Serum N/A
Human CFH-26763TH Recombinant Human CFH, His-tagged E.coli His
Human CFH-3183H Recombinant Human CFH, His tagged Human Cell His
Human CFH-641H Recombinant Human CFH protein, His-tagged E.coli His Ser860~Arg1231
Human CFH-1168H Recombinant Human CFH Protein, GST-Tagged Wheat Germ GST
Human CFH-2409HCL Recombinant Human CFH cell lysate Human Cell N/A
Human CFH-762H Recombinant Human CFH Protein, His-tagged HEK293F N-His Gly1107-Arg1231
Human CFH-3295HF Recombinant Full Length Human CFH Protein, GST-tagged In Vitro Cell Free System GST 449 amino acids
Human CFH-763H Recombinant Human CFH Protein, His-tagged E.coli N-His Glu19-Leu322
Human CFH-1048H Recombinant Human CFH Protein (Glu19-Pro346), N-His tagged E.coli N-His Glu19-Pro346
Human DMABT-H19244 Mouse Anti-CFH Monoclonal Antibody Mouse N/A
Human CAB11509MH Mouse Anti-Human Complement Factor H Monoclonal Antibody Mouse N/A
Human CFH-1180H Recombinant Human CFH Protein (Glu19-Leu449), C-His tagged Mammalian cells C-His Glu19-Leu449
Mouse Cfh-626M Active Recombinant Mouse Cfh Protein, His-tagged Mammalian cells His Ser875-Val1252
Mouse Cfh-396M Recombinant Mouse Cfh protein, hFc-tagged HEK293 hFc Ser875-Val1252
Mouse Cfh-392M Recombinant Mouse Cfh protein, His-tagged HEK293 His Ser875-Val1252
Mouse Cfh-642M Recombinant Mouse Cfh protein, His & T7-tagged E.coli His/T7 Glu915~Thr1156 (Accession # P06909)
Mouse Cfh-1612M-B Recombinant Mouse Cfh Protein Pre-coupled Magnetic Beads HEK293
Mouse Cfh-761M Recombinant Mouse Cfh Protein, His-tagged E.coli N-His Ser877-Val1234
Mouse Cfh-1612M Recombinant Mouse Cfh Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cfh-643R Recombinant Rat Cfh protein, His-tagged E.coli His Ala975~Ser1217 (Accession # G3V9R2)
Cattle CFH-640C Recombinant Cattle CFH protein, His & T7-tagged E.coli His/T7 Gly879~Gly1236 (Accession# Q28085)
Zebrafish CFH-7847Z Recombinant Zebrafish CFH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CFH Related Articles
  • CFH Related Research Area

CFH involved in several pathways and played different roles in them. We selected most pathways CFH participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSerpina1c;BDKRB1;F13B;SERPIND1;CD46;PLG;C5;SERPINA1D;GM5077
Staphylococcus aureus infectionC1QB;C1R;SELP;FCGR1A;FCGR4;ITGB2L;SELPLG;ICAM1;H2-AB1

CFH has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFH itself. We selected most functions CFH had, and list some proteins which have the same functions with CFH. You can find most of the proteins on our site.

Function Related Protein
heparan sulfate proteoglycan bindingGPC6;AZU1;Gpc2;HPSE2;GPC1B;GPC3;FST;ITGAM;UBE4A
heparin bindingAPLP1;PTPRFB;PDCD5;LPL;FGF9;APP;BSPH1;FGFR1;HRG
protein bindingZNF664-FAM101A;CDK20;BCKDHA;DCTN4;WBSCR27;CROP;TUFM;DMC1;ZNF193

CFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFH here. Most of them are supplied by our site. Hope this information will be useful for your research of CFH.

C3; C3; ennX; TFAP2A; VDR; GRB2; SMAD3; ZBTB16; EP300; q81p70_bacan; colA; TFAP2C; YTHDC1; q99ib8-pro_0000045596; d-mannose; ALB

Cortina, G; Trojer, R; et al. De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. PEDIATRIC NEPHROLOGY 30:693-697(2015).
Khandelwal, P; Gupta, A; et al. Effect of plasma exchange and immunosuppressive medications on antibody titers and outcome in anti-complement factor H antibody-associated hemolytic uremic syndrome. PEDIATRIC NEPHROLOGY 30:451-457(2015).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of CFH mutations on the risk of developing atypical hemolytic uremic syndrome (aHUS)? 02/13/2022

Mutations in CFH increase the risk of aHUS, affecting complement regulation and leading to kidney damage.

How does CFH (Complement Factor H) regulate the complement system and prevent overactivation? 06/07/2021

CFH controls the complement system, preventing its overactivation and protecting against immune damage.

How does CFH influence the immune response to bacterial infections? 01/07/2020

CFH modulates the immune response to bacterial infections, balancing defense mechanisms.

How does CFH deficiency contribute to the development of age-related macular degeneration (AMD)? 09/09/2019

CFH deficiency is linked to AMD, due to impaired regulation of the complement pathway in the retina.

What role does CFH play in protecting host cells from complement-mediated damage? 04/03/2019

CFH shields host cells from complement-mediated injury, maintaining tissue integrity.

What are the mechanisms by which CFH modulates inflammation and immune homeostasis? 01/23/2019

CFH regulates inflammation and maintains immune balance, crucial for preventing excessive immune responses.

How do alterations in CFH expression or function affect renal function and the development of kidney diseases? 01/18/2018

Changes in CFH function can impact kidney health, potentially leading to renal diseases due to altered complement activity.

Customer Reviews (3)

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Reviews
11/16/2020

    Exceptional protein expression optimization support, highly appreciated assistance.

    07/31/2020

      Precise protein quantification, ensures data accuracy in our research.

      03/10/2018

        Timely antibody validation, an invaluable asset for our laboratory.

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