Active Native Human Complement factor H

• Cat.No.: CFH-23H
• Product Overview: Native Human Complement factor H was purified from normal human serum.

Specification

• Description: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: Human serum
• Species: Human
• Bio-activity: >90% versus normal human serum standard
• Molecular Mass: 155,000 Da (single chain)
• Purity: >95% by SDS-PAGE
• Storage: -70°C or below. Avoid freeze/thaw.
• Concentration: 1.0 mg/mL
• Storage Buffer: 10 mM sodium phosphate, 145 mM NaCl, pH 7.3
• Preservative: None, 0.22 µm filtered

Gene Information

• Gene Name: CFH complement factor H [ Homo sapiens (human) ]
• Official Symbol: CFH
• Synonyms: complement factor H; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; CFH; complement factor H; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1
• Gene ID: 3075
• mRNA Refseq: NM_000186
• Protein Refseq: NP_000177
• MIM: 134370
• UniProt ID: P08603
• Chromosome Location: 1q32
• Pathway: Complement and coagulation cascades; Immune System; Staphylococcus aureus infection
• Function: heparan sulfate proteoglycan binding; heparin binding; protein binding