chmp4b
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  • Official Full Name
  • charged multivesicular body protein 4B
  • Background
  • This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
  • Synonyms
  • CHMP4B; charged multivesicular body protein 4B; C20orf178, chromatin modifying protein 4B , chromosome 20 open reading frame 178; dJ553F4.4; Shax1; SNF7 2; VPS32B; hSnf7-2; hVps32-2; chromatin modifying protein 4B
Cat.#:CHMP4B-3237HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CHMP4B Protein, MYC/DDK-tagged
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Cat.#:CHMP4B-11187HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHMP4B, GST-tagged
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Cat.#:CHMP4B-3408MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHMP4B Protein
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Cat.#:CHMP4B-1431CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHMP4B
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Cat.#:CHMP4B-12626ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CHMP4B
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Cat.#:CHMP4B-186HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CHMP4B lysate
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Involved Pathway

CHMP4B involved in several pathways and played different roles in them. We selected most pathways CHMP4B participated on our site, such as Budding and maturation of HIV virion, Cellular responses to stress, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP4B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Budding and maturation of HIV virion
VPS37A; CHMP4B; CHMP4C; gag; PPIA; PDCD6IP
Cellular responses to stress
RAD50; HIST1H1C; TXN; LAMTOR1; EGLN1B; AMBRA1B; SUZ12; SUZ12A; BMI1B; GABARAP
Disease
AMN; SFTPB; gag; OPN1SW; CCDC167; SUPT4H1; CPSF6; DOCK2; PPIA; CCDC59
Endocytosis
PIP5K1BA; FAM125B; PIP5K1B; ARPC4L; SNX1A; RAB11FIP2; ACAP2; PARD6A; RHOAD; CXCR4A
Endosomal Sorting Complex Required For Transport (ESCRT)
STAM2; VPS37A; SNF8; CHMP4B; CHMP4C
HIV Infection
RCC1; PSTPIP2; DOCK2; APOBEC3G; CDK9; NPM1; CHMP4C; PPIAL4A; CHMP4B; SSRP1
HIV Life Cycle
SSRP1; CHMP4B; ELL; PDCD6IP; CDK9; TAF1L; PSIP1; NMT1; NMT2; VPS37A
Infectious disease
NMT1; RCC1; CHMP4B; SYT2; PACS1; CCDC167; STX1B; NMT2; ANTXR2; KPNA3

Protein Function

CHMP4B has several biochemical functions, for example, identical protein binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP4B itself. We selected most functions CHMP4B had, and list some proteins which have the same functions with CHMP4B. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein MSANTD3; PDCD6; FGFR1; CCT7; SNX1; ACTN2; PLDN; STK4; SP100; PSMA7
Function protein binding
Related Protein EVI5L; HIST1H3H; ACKR4; PALLD; ADRA2A; ANKRD45; TSC22D4; MAPKAPK5; GM885; DGCR6L
Function protein homodimerization activity
Related Protein PYGB; ADD2; SYNDIG1; HMGCR; PLDN; MIXL1; TG; Il6ra; PARK7; QDPR

Interacting Protein

CHMP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP4B.
ATP6V1A; PTPN23; USP8; USP54; PRKAR1A; Chmp3; STAMBP; HTT; UBE2I; Baz2b; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; TCEB1; e9psi1_human; TAF1; AIM2; CHMP2A