|Official Full Name||Claudin 12|
|Background||This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.|
|Synonyms||Cldn12; claudin-12; OTTHUMP00000024518; OTTHUMP00000067944; OTTHUMP00000082755; OTTHUMP00000212898|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CLDN12 involved in several pathways and played different roles in them. We selected most pathways CLDN12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
CLDN12 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN12 itself. We selected most functions CLDN12 had, and list some proteins which have the same functions with CLDN12. You can find most of the proteins on our site.
|structural molecule activity||NEFMB; LCE3E; MAPK8IP2; CRCT1; KRTAP3-1; EVPLA; NPHP1; KRT27; CLDN7B; KRT72-PS|
CLDN12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN12.