This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
COL4A2; collagen, type IV, alpha 2; collagen alpha-2(IV) chain; canstatin; collagen type IV alpha 2; DKFZp686I14213; FLJ22259; ICH; POREN2
COL4A2 involved in several pathways and played different roles in them. We selected most pathways COL4A2 participated on our site, such as Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Seidl, C; Port, M; et al. Differential gene expression triggered by highly cytotoxic alpha-Emitter-immunoconjugates in gastric cancer cells. INVESTIGATIONAL NEW DRUGS 28:49-60(2010).
Poschl, E; Schlotzer-Schrehardt, U; et al. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. DEVELOPMENT 131:1619-1628(2004).