Recombinant Mouse COL4A2 Protein (1481-1707 aa), His-tagged

• Cat.No.: COL4A2-2373M
• Product Overview: Recombinant Mouse COL4A2 Protein (1481-1707 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 29.1 kDa
• Protein length: 1481-1707 aa
• AA Sequence: VSIGYLLVKHSQTDQEPMCPVGMNK LWSGYSLLYFEGQEKAHNQDLGLAG SCLARFSTMPFLYCNPGDVCYYASR NDKSYWLSTTAPLPMMPVAEEEIKP YISRCSVCEAPAVAIAVHSQDTSIP HCPAGWRSLWIGYSFLMHTAAGDEG GGQSLVSPGSCLEDFRATPFIECNG GRGTCHYFANKYSFWLTTIPEQNFQ STPSADTLKAGLIRTHISRCQVCMK NL
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Col4a2 collagen, type IV, alpha 2 [ Mus musculus ]
• Official Symbol: COL4A2
• Synonyms: COL4A2; collagen, type IV, alpha 2; collagen alpha-2(IV) chain; canstatin; Col4a-2; MGC7371
• Gene ID: 12827
• mRNA Refseq: NM_009932
• Protein Refseq: NP_034062
• UniProt ID: P08122