col4a6
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  • Official Full Name
  • collagen, type IV, alpha 6
  • Background
  • This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.
  • Synonyms
  • COL4A6; collagen, type IV, alpha 6; collagen alpha-6(IV) chain; collagen alpha 6 type IV; collagen IV, alpha-6 polypeptide; dJ889N15.4 (Collagen Alpha 6(IV)); collagen of basement membrane, alpha-6; DELXq22.3; CXDELq22.3; MGC88184
Cat.#:COL4A6-1654HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL4A6 Protein, GST-tagged
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Cat.#:COL4A6-11436HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A6, GST-tagged
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Involved Pathway

COL4A6 involved in several pathways and played different roles in them. We selected most pathways COL4A6 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
ACTN1; PRKACG; CSF2; SERPINB3C; ITGB2; LAMB2; PRKCA; AASS; HSPB1; CTSG
Assembly of collagen fibrils and other multimeric structures
COL8A1A; DST; TLL2; PLEC; LOXL3; COL3A1; MMP13; COL5A2; CTSS; PCOLCE
Collagen biosynthesis and modifying enzymes
COL9A1; COL11A1B; COL4A3; COL9A1A; COL23A1; ADAMTS2; COL25A1; PCOLCE2B; ADAMTS3; COL4A6
Collagen formation
COL5A3B; COL6A2; PRP; LOXL4; CRTAP; COL11A1B; COL9A1; PPIB; COL28A1; LOXL1
ECM-receptor interaction
ITGA11A; COL11A1A; ITGA4; LAMA2; VTNB; ITGA8; COMP; COL6A4; LAMB1A; SDC1
Extracellular matrix organization
COL28A1D; COL11A1B; HAPLN1; COL15A1B; PCOLCE2B; TIMP2A; COL28A1; TLL1; SPARC; MMP17
Focal Adhesion
MYL12A; PIK3R3B; ITGA9; RAC2; ITGB3B; MYLK2; RAC1A; PPP1CAA; BAD; ITGA4

Protein Function

COL4A6 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A6 itself. We selected most functions COL4A6 had, and list some proteins which have the same functions with COL4A6. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent
Related Protein KAL1; CD4; COL5A1; TINAGL1; COL27A1B; PRELP; CHI3L1; FBLN2; MGP; COL11A2

Interacting Protein

COL4A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A6.
KLK6; OSM

COL4A6 Related Articles

Tveita, AA; Ninomiya, Y; et al. Development of lupus nephritis is associated with qualitative changes in the glomerular collagen IV matrix composition. LUPUS 18:355-360(2009).
Ikeda, K; Iyama, K; et al. Loss of expression of type IV collagen alpha 5 and alpha 6 chains in colorectal cancer associated with the hypermethylation of their promoter region. AMERICAN JOURNAL OF PATHOLOGY 168:856-865(2006).