commd1
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  • Official Full Name
  • copper metabolism (Murr1) domain containing 1
  • Background
  • COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al.,;2005 (PubMed 16267171)).
  • Synonyms
  • COMMD1; copper metabolism (Murr1) domain containing 1; C2orf5, chromosome 2 open reading frame 5 (MURR1); COMM domain-containing protein 1; copper metabolism gene MURR1; MGC27155; MURR1; C2orf5; COMD1; COMD1_HUMAN; copper metabolism domain containing 1; Protein Murr1; OTTHUMP00000159817
Cat.#:COMMD1-1674HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COMMD1 Protein, GST-tagged
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Cat.#:COMMD1-2732HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMMD1, His-tagged
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Cat.#:COMMD1-28013THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMMD1, His-tagged
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Cat.#:COMMD1-28014THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMMD1, His-tagged
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Cat.#:COMMD1-4265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COMMD1
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Cat.#:COMMD1-7373HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COMMD1 293 Cell Lysate
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Involved Pathway

COMMD1 involved in several pathways and played different roles in them. We selected most pathways COMMD1 participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMMD1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TNF-alpha/NF-kB Signaling Pathway
DCAF7; PEG3; CSNK2A1P; PDCD2; NKIRAS1; TANK; KTN1; RNF216; PPP1R13L; PAPOLA

Protein Function

COMMD1 has several biochemical functions, for example, copper ion binding, identical protein binding, phosphatidic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COMMD1 itself. We selected most functions COMMD1 had, and list some proteins which have the same functions with COMMD1. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein CCC2; COX17; LOXL3B; SCO2; MT3; S100A5; ADNP; APOA4; LOXL4; TYRP1
Function identical protein binding
Related Protein LRP6; PLK4; KHDC1A; SH3GLB1; CLDND; CLDN14; SH2B2; HSPB8; FBLN1; PRC1
Function phosphatidic acid binding
Related Protein SESTD1; RAPGEF6; MICALL1; NRGN; MARK1; UQCC3; JPH2; COMMD1; PACSIN2; MAPKAP1
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein JPH2; ASAP1; ADAP2; RAG2; ZFYVE1; ZFYVE16; OGT; MYO1G; KIF16B; ANXA8
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein ANXA8; PLEKHA1; MAPKAP1; COMMD1; TTPA; FAM21C; AKT1; RS1; GAB2; D6WSU116E
Function phosphatidylinositol-3,5-bisphosphate binding
Related Protein KIF16B; PHLDA3; D6WSU116E; WDR45L; CLVS1; GBF1; MAPKAP1; SNX14; SH3PXD2B; SNX3
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein PFN1; JPH2; SESTD1; KCNJ2; LDLRAP1; TWF2; ASAP1; SNX20; VIL1; MAPKAP1
Function protein binding
Related Protein C7orf31; C19orf40; PLD2; HPX; NLRX1; BAAT; RBBP6; MYL12A; WASF2; CDKN3
Function protein homodimerization activity
Related Protein SMAD3; MYOM1; COMMD1; NR2C1; ENG; DMBX1; ODZ4; ANXA9; SLC39A13; PDE2A

Interacting Protein

COMMD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMMD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COMMD1.
COMMD6; CCDC22

COMMD1 Related Articles

Phillips-Krawczak, CA; Singla, A; et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. MOLECULAR BIOLOGY OF THE CELL 26:91-103(2015).
Li, HY; Burstein, E; et al. COMMD1 regulates inflammation and colitis-associated cancer progression. ONCOIMMUNOLOGY 3:-(2014).