creb5
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  • Official Full Name
  • cAMP responsive element binding protein 5
  • Background
  • The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family;contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a;heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript;variants encoding different isoforms have been identified.
  • Synonyms
  • CREB5; cAMP responsive element binding protein 5; cyclic AMP-responsive element-binding protein 5; cAMP response element binding protein CRE Bpa; CRE BPA; H_GS165L15.1; CREB-5; cAMP-responsive element-binding protein 5; cAMP response element binding prote
Cat.#:CREB5-1850HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CREB5 Protein, GST-tagged
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Cat.#:CREB5-1112HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CREB5 protein, His & T7-tagged
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Cat.#:CREB5-3892MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CREB5 Protein
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Cat.#:CREB5-7286HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CREB5 293 Cell Lysate
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Involved Pathway

CREB5 involved in several pathways and played different roles in them. We selected most pathways CREB5 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
PDE2A; PPP1CC; PIK3CA; GNAI3; MYLK; NPPB; PRKCE; VDAC1; VASP; ROCK2
cAMP signaling pathway
VAV2; PRKACG; MLLT4; PLD1; GNAS; GRIN1; GLI3; ATP1A3; CREB3L2; ARAP3
PIK-Akt signaling pathway
IFNA13; TCL1B1; PIK3CD; PRKCA; IRS1; FGF14; CREB3L1; LAMA4; IL2RA; G6PC3
AMPK signaling pathway
GYS2; STRADB; CREB3L2; PPP2R5D; PIK3CB; HMGCR; PFKP; STK11; PIK3CD; CREB3L3
Adrenergic signaling in cardiomyocytes
ATP1A3B; ATP1B2A; CACNG2; CAMK2A; PRKCA; CACNA2D4; ADRA1B; ADCY3; ATF2; ACTC1A
TNF signaling pathway
MAPK10; MAP3K14; TRAF3; TAB2; CCL20; MMP14; MAPK12; TRAF1; MAP2K3; CXCL5
Cholinergic synapse
PIK3R1; ITPR3; GNG8; PIK3CD; GNG11; AKR1C1; PLCB4; GNB1; GNA11; KCNQ3
Dopaminergic synapse
PPP2R3A; ITPR3; PLCB1; CREB3L4; MAPK12; GNAI3; PPP1CB; MAOB; PPP2R5C; DRD5
Insulin secretion
INS2; INS; FFAR1; KCNN4; KCNMB3; PLCB4; CCKAR; GNAQ; SLC2A2; PRKCG
Estrogen signaling pathway
GRB2; PRKACA; PLCB3; CREB3L3; HSPA1B; PIK3CD; ESR1; PIK3R5; HSPA1L; HSP90AB1
Thyroid hormone synthesis
ASGR1; PLCB3; TG; GPX8; GPX3; ITPR1; ATP1B3; IYD; DUOX2; TTF2
Glucagon signaling pathway
ITPR1; ITPR3; PPARGC1A; PRKAB2; GNAS; FBP1; PCK2; PPP3R1; PPARA; GNAQ
Aldosterone synthesis and secretion
GNAS; ADCY7; ITPR3; ADCY8; ATF2; ADCY9; HSD3B6; NR4A1; NPR1; STAR
Insulin resistance
PRKAG3B; CREB3L3L; PPARGC1A; PPP1CAB; PRKCDA; TNF; SLC2A1; SOCS3; MTOR; PRKCZ
Vasopressin-regulated water reabsorption
ARHGDIB; DCTN6; STX4; NSF; AQP3; AVP; CREB3L2; DYNC1LI2; AQP4; RAB11A
Huntingtons disease
NRF1; COX6A1; COX7A2; NDUFA12; NDUFA8; POLR2C; PPARGC1A; NDUFB1; SDHC; PLCB2
Cocaine addiction
GRIN2B; GNAI1; CDK5R1; GRIN2A; PRKACG; CREB3; DRD1A; RELA; GRIN3B; FOSB
Amphetamine addiction
FOSB; CALML5; PRKACB; GRIN3A; ATF4; GNAS; JUN; GRIN2C; MAOB; PPP1CA
Alcoholism
SLC6A3; SOS1; HIST1H4D; HDAC3; KRAS; PPP1CC; FOSB; HIST1H4L; HIST1H4K; HIST1H4N
Hepatitis B
CCND1; IFIH1; IFN-a; NRAS; MAVS; BAD; STAT1; IFNA16; GRB2; APAF1
Viral carcinogenesis
HLA-E; CCNE2; YWHAZ; HIST1H4B; CCND2; HIST1H2BA; CCNA1; HIST1H4D; GSN; HIST1H2BN
Prostate cancer
HSP90AA1; NDRG1; NKX3-1; TRP53; PDGFB; LEF1; SMARCA4; PIK3R5; CPN1; SRD5A2

Protein Function

CREB5 has several biochemical functions, for example, metal ion binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB5 itself. We selected most functions CREB5 had, and list some proteins which have the same functions with CREB5. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein MMP13A; ZNF19; ZNF728; PDE4A; WTIP; FKBP8; MBLAC1; SMAP2; RPE65B; NRXN1
Function protein binding
Related Protein ASGR1; LSAMP; RUNX3; TP53; CASP2; ZSCAN12; GP1BB; COPS4; EHD3; RPS16
Function sequence-specific DNA binding
Related Protein UNCX; NR5A2; HOXB3A; VSX1; NKX2.4B; FOXO3B; NR6A1; TRP53; PAX7B; MAFG
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATF3; PPARAB; TFEB; GTF2H3; TFAP2B; FOXN4; ZNF561; FOXA1; ZIC3; HIVEP2

Interacting Protein

CREB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB5.
KRTAP5-9; LGALS13

CREB5 Related Articles

Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
Erion, DM; Kotas, ME; et al. cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16167-16176(2013).