cst4
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  • Official Full Name
  • cystatin S
  • Background
  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function.
  • Synonyms
  • CST4; cystatin S; cystatin-S; Cystatin 4; Cystatin S precursor; Cystatin SA III; Cystatin-4; Cystatin-SA-III; CYTS_HUMAN; MGC71923; Salivary acidic protein 1; OTTHUMP00000030443
Cat.#:CST4-2027HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CST4 Protein, GST-tagged
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Cat.#:CST4-3353HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST4 Protein, MYC/DDK-tagged
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Cat.#:CST4-27162THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CST4
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Cat.#:CST4-3212HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST4, His tagged
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Cat.#:CST4-378HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CST4 Protein, His-tagged
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Cat.#:CST4-6768HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CST4, His-tagged
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Cat.#:CYSS-1762RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYSS Protein
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Cat.#:CST4-2241HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST4 cell lysate
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Involved Pathway

CST4 involved in several pathways and played different roles in them. We selected most pathways CST4 participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Salivary secretion
AMY1B; AMY1A; LYZ1; PRB1; ATP1A4; PRKACG; ATP1A3; PLCB2; GUCY1A3; CALM3

Protein Function

CST4 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST4 itself. We selected most functions CST4 had, and list some proteins which have the same functions with CST4. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase inhibitor activity
Related Protein BIRC5B; AHSG; CTLA2B; CSTL1; LCN1; KNG1; BIRC5; Cstb; STFA2; AHSG1

Interacting Protein

CST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST4.
SOD2; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

CST4 Related Articles

Zhang, Q; Zhao, XZ; et al. Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. PROTEIN EXPRESSION AND PURIFICATION 104:14-19(2014).
Fine, JD; Bruckner-Tuderman, L; et al. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 70:1103-1126(2014).