| Official Full Name | Cathepsin L2 |
| Background | Cathepsin V, also known as Cathepsin L2, is a 334 amino acid protein that belongs to the peptidase C1 family and is found in the lysosome. It is a Cysteine protease that may have an important role in corneal physiology. It can also function as a hydrolase and thiol protease. The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Cathepsin V is expressed predominantly in the thymus and testis. It is also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. |
| Synonyms | UNQ268/PRO305; CATL2; CTSU; CTSV; cathepsin L2, preproprotein; cathepsin U; cathepsin V |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
CTSL2 involved in several pathways and played different roles in them. We selected most pathways CTSL2 participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | LOC100686744; TIMP2; MMP17; ELANE; MMP15; MMP13; CTRB1; FURINB; TIMP2A; TPSAB1 |
| Adaptive Immune System | KIF18A; KIF3B; CD300LF; CD200R4; GM11711; PIK3AP1; SH3RF1; FRS2; ASB2; TRIM69 |
| Antigen processing-Cross presentation | SEC61B; CYBB; CD207; FCGR1B; CTSL2; CYBA; CTSS; CTSL1 |
| Assembly of collagen fibrils and other multimeric structures | COL11A1B; COL4A5; LOXL3; BMP1B; COL6A1; PLEC; COL10A1; BMP1A; COL5A3A; LOX |
| Class I MHC mediated antigen processing & | STUB1; ASB2; UBR1; ERAP2; UBE2U; TRIM9; UBA5; TRIM69; TPP2; ASB9 |
| presentation | SH3RF1; ATG7; UBE2L6; FCGR1B; TRIM41; ASB18; ERAP2; RNF123; CYBB; ASB14 |
| Collagen formation | COL25A1; BMP1; ADAMTS2; SERPINH1B; PCOLCE2; COL5A3A; CRTAP; CTSL2; COL9A1B; LOX |
| Degradation of the extracellular matrix | MGC174857; FURINA; CTSLL; COL17A1; MMP8; BMP1; FAM49BA; MMP24; ADAM8; TIMP2A |
| Endochondral Ossification | DDR2; SOX9A; ADAMTS5; CTSL2; COL10A1; NKX3.2; FRZB; MMP13; IFT88; ADAMTS1 |
CTSL2 has several biochemical functions, for example, aminopeptidase activity, cysteine-type carboxypeptidase activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL2 itself. We selected most functions CTSL2 had, and list some proteins which have the same functions with CTSL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | RNPEP; LAP3; TRHDE; CTSH; Ctsl; METAP1; ERAP2; ANPEP; PEPD; XPNPEP1 |
| cysteine-type carboxypeptidase activity | CTSL2; Ctsl |
| cysteine-type endopeptidase activity | USP43A; CTSL1; USP42; CASPA; USP12; USP19; Ctsl; USP17L2; CTSL2; CTSC |
| cysteine-type peptidase activity | CAPN3B; USP9; CAPN2A; CTSJ; CTSLL; CAPN3A; ZRANB1B; CASPBL; CAPN12; USP27X |
| histone binding | NASP; RNF20; USP16; BAZ2A; UHRF2; RNF168; HIST1H4A; HIST4H4; ASF1A; SART3 |
| kininogen binding | C1QBP; Ctsl; CTSB; CTSL2 |
| peptide binding | ERAP1; CTSB; RNPEPL1; NLN; CTSL2; Ctsl; GNRHR1; GNRHR; IDE; ANG |
| protein binding | CTH; LRP6; HOOK2; BID; SPHK1; CHD7; RUFY4; RAB1; METTL17; KCNA4 |
| protein complex binding | UQCRFS1; CALCA; PPP2R2A; NOG; LRRC16A; PTPRF; DRD1; KLHL8; PDX1; RAP1A |
CTSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL2.
srp-6; BUB1; RB1; SRC; BRAF; APC; CTNNA1; BMPR1A; MLH1; DCC; PDGFRL; CDKN2A; DLC1; MLH3
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