CTSL2 Protein, Cathepsin L2


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Official Full Name Cathepsin L2
Background Cathepsin V, also known as Cathepsin L2, is a 334 amino acid protein that belongs to the peptidase C1 family and is found in the lysosome. It is a Cysteine protease that may have an important role in corneal physiology. It can also function as a hydrolase and thiol protease. The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Cathepsin V is expressed predominantly in the thymus and testis. It is also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
Synonyms UNQ268/PRO305; CATL2; CTSU; CTSV; cathepsin L2, preproprotein; cathepsin U; cathepsin V
    • Species :
    • Chicken
    • Human
    • Source :
    • Free Style 293-F Cell
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NSO
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTSL2-507H Recombinant Human Cathepsin L2, His-tagged Free Style 293-F Cell His
    Human CTSL2-614H Recombinant Human CTSL2, His tagged Human Cell His
    Human CTSL2-681H Recombinant Human Cathepsin L2, His-tagged Insect Cell His
    Human CTSL2-7191HCL Recombinant Human CTSL2 293 Cell Lysate HEK293 N/A
    Human CTSL2-751H Recombinant Human Cathepsin L2, His-tagged NSO His
    Chicken CTSL2-4041C Recombinant Chicken CTSL2 Mammalian Cell His

    CTSL2 involved in several pathways and played different roles in them. We selected most pathways CTSL2 participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases LOC100686744; TIMP2; MMP17; ELANE; MMP15; MMP13; CTRB1; FURINB; TIMP2A; TPSAB1
    Adaptive Immune System KIF18A; KIF3B; CD300LF; CD200R4; GM11711; PIK3AP1; SH3RF1; FRS2; ASB2; TRIM69
    Antigen processing-Cross presentation SEC61B; CYBB; CD207; FCGR1B; CTSL2; CYBA; CTSS; CTSL1
    Assembly of collagen fibrils and other multimeric structures COL11A1B; COL4A5; LOXL3; BMP1B; COL6A1; PLEC; COL10A1; BMP1A; COL5A3A; LOX
    Class I MHC mediated antigen processing &amp STUB1; ASB2; UBR1; ERAP2; UBE2U; TRIM9; UBA5; TRIM69; TPP2; ASB9
    presentation SH3RF1; ATG7; UBE2L6; FCGR1B; TRIM41; ASB18; ERAP2; RNF123; CYBB; ASB14
    Collagen formation COL25A1; BMP1; ADAMTS2; SERPINH1B; PCOLCE2; COL5A3A; CRTAP; CTSL2; COL9A1B; LOX
    Degradation of the extracellular matrix MGC174857; FURINA; CTSLL; COL17A1; MMP8; BMP1; FAM49BA; MMP24; ADAM8; TIMP2A
    Endochondral Ossification DDR2; SOX9A; ADAMTS5; CTSL2; COL10A1; NKX3.2; FRZB; MMP13; IFT88; ADAMTS1

    CTSL2 has several biochemical functions, for example, aminopeptidase activity, cysteine-type carboxypeptidase activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL2 itself. We selected most functions CTSL2 had, and list some proteins which have the same functions with CTSL2. You can find most of the proteins on our site.

    Function Related Protein
    aminopeptidase activity RNPEP; LAP3; TRHDE; CTSH; Ctsl; METAP1; ERAP2; ANPEP; PEPD; XPNPEP1
    cysteine-type carboxypeptidase activity CTSL2; Ctsl
    cysteine-type endopeptidase activity USP43A; CTSL1; USP42; CASPA; USP12; USP19; Ctsl; USP17L2; CTSL2; CTSC
    cysteine-type peptidase activity CAPN3B; USP9; CAPN2A; CTSJ; CTSLL; CAPN3A; ZRANB1B; CASPBL; CAPN12; USP27X
    histone binding NASP; RNF20; USP16; BAZ2A; UHRF2; RNF168; HIST1H4A; HIST4H4; ASF1A; SART3
    kininogen binding C1QBP; Ctsl; CTSB; CTSL2
    peptide binding ERAP1; CTSB; RNPEPL1; NLN; CTSL2; Ctsl; GNRHR1; GNRHR; IDE; ANG
    protein binding CTH; LRP6; HOOK2; BID; SPHK1; CHD7; RUFY4; RAB1; METTL17; KCNA4
    protein complex binding UQCRFS1; CALCA; PPP2R2A; NOG; LRRC16A; PTPRF; DRD1; KLHL8; PDX1; RAP1A

    CTSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL2.


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