CYP27B1 Protein, cytochrome P450, family 27, subfamily B, polypeptide 1


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Official Full Name cytochrome P450, family 27, subfamily B, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Synonyms CYP27B1; cytochrome P450, family 27, subfamily B, polypeptide 1; cytochrome P450, subfamily XXVIIB (25 hydroxyvitamin D 1 alpha hydroxylase), polypeptide 1 , PDDR, VDD1; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 1alpha(OH)ase; 25 Hydroxyvita
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP27B1-2254H Recombinant Human CYP27B1 Protein, GST-tagged Wheat Germ GST
    Human CYP27B1-7118HCL Recombinant Human CYP27B1 293 Cell Lysate HEK293 N/A
    Human CYP27B1-8069H Recombinant Human CYP27B1 protein, His & T7-tagged E.coli His/T7
    Human CYP27B1-856H Recombinant Human CYP27B1 Protein, His-tagged E.coli His
    Mouse CYP27B1-4157M Recombinant Mouse CYP27B1 Protein Mammalian Cell His
    Mouse Cyp27b1-8070M Recombinant Mouse Cyp27b1 protein, His & T7-tagged E.coli His/T7
    Rat CYP27B1-1722R Recombinant Rat CYP27B1 Protein Mammalian Cell His
    Rat Cyp27b1-8071R Recombinant Rat Cyp27b1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CYP27B1-1142R Recombinant Rhesus monkey CYP27B1 Protein, His-tagged Mammalian Cell His

    CYP27B1 involved in several pathways and played different roles in them. We selected most pathways CYP27B1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP27B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations Sult2a6; FDX1; CYP2K18; CES1; ADH1B; GGT6; CYP11B1; UGT1B1; CYP51A1; CYP3A7-CYP3AP1
    Cytochrome P450 - arranged by substrate type CYP2N13; CYP2K19; CYP3A5; CYP4T8; CYP2K6; CYP4F22; CYP2C19; CYP2V1; CYP19A1; CYP2A13
    Metabolic pathways HSD3B6; UQCRC2A; MAOB; NDUFV2; PLA2G5; LCLAT1; UGT2B7; UGP2B; DNMT3AB; NADKB
    Metabolism PPP1R2; MED16; COX6C; FABP11B; CYP3C4; GLS2B; FAM36A; NUDT5; CKM; AKR1C4
    Metabolism of lipids and lipoproteins CSNK1G2; CDK19; MED20; YAP1; CETP; APOA4B.2; MED29; ACAD11; MED31; COQ7
    Metabolism of steroid hormones and vitamin D PPP1R2; CYP24A1; CYP2R1; AKR1B15; STARD5; GC; HSD17B11; CYP27B1
    Nuclear receptors in lipid metabolism and toxicity ABCC2; NR1I3; RARGA; RARGB; RARG; NR1I2; CYP27B1; CYP24A1; VDRB; CYP26A1
    Phase 1 - Functionalization of compounds CYP26A1; CYP3C1; CYP3C4; CYP3A7-CYP3AP1; CYP27B1; CES1; CYP2K6; CYP2W1; CYP4F12; CYP2K19

    CYP27B1 has several biochemical functions, for example, calcidiol 1-monooxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP27B1 itself. We selected most functions CYP27B1 had, and list some proteins which have the same functions with CYP27B1. You can find most of the proteins on our site.

    Function Related Protein
    calcidiol 1-monooxygenase activity IRGM1; CYP27B1
    heme binding CYP2AA3; SDHD; CAT; CYP19A1A; MPO; CYP17A1; CYB5B; CYP24A1; CYP2K19; CYP3A7
    iron ion binding CYP2A7; HBE; LEPREL2; CYP2Y3; LTF; CYP4F2; NFU1; TPH1B; HBD; TPH1A

    CYP27B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP27B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP27B1.

    Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).
    Rolf, L; Muris, AH; et al. Vitamin D effects on B cell function in autoimmunity. STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I 1317:84-91(2014).

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