cyp2a6
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  • Official Full Name
  • cytochrome P450, family 2, subfamily A, polypeptide 6
  • Background
  • This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
  • Synonyms
  • CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6; CYP2A3, cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 6; cytochrome P450 2A6; CPA6; CYP2A; cytochrome P450(I); cytochrome P450 IIA3; coumarin 7-hydroxylase; xenobiotic
Cat.#:CYP2A6-2258HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2A6 Protein, GST-tagged
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Cat.#:CYP2A6-125HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2A6
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Cat.#:CYP2A6-126HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2A6, MYC/DDK-tagged
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Cat.#:CYP2A6-27019THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP2A6
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Cat.#:CYP2A6-7117HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2A6 293 Cell Lysate
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Cat.#:Kit-0923Tag:
Source (Host):Species:
Product nameCYP2A6 Blue Screening Kit
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Involved Pathway

CYP2A6 involved in several pathways and played different roles in them. We selected most pathways CYP2A6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Caffeine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CES1; PRKRA; SULT2ST1; CYP7A1; GLYATL1; Sult2a6; CYP51A1; CYP11B1; ADH7; ADH4
CYP2E1 reactions
CYP2A6; CYP2D6; CYP2E1; CYP2A7; CYP2A13; CYP2F1; CYP2C9; CYP2Y3; CYP2S1; CYP2B6
Caffeine metabolism
NAT1; CYP1A2; PNAT10; CYP2A6; PNAT3; UOX; XDH; NAT; NAT2; Nat3
Chemical carcinogenesis
UGT1A2; ADH2-1; UGT1A7; ADH1A; ALDH3B2; CCBL2; HSD11B1; AKR1C2; EPHX1; CYP2A13
Cytochrome P450 - arranged by substrate type
CYP3C4; CYP2F1; CYP1B1; CYP2C8; CYP46A1; CYP19A1; CYP2AD2; CYP4F22; CYP2Y3; CYP2K8
Drug metabolism - cytochrome P450
ADH6; CYP2D6; ADH4; ADH5; CYP3A5; CYP2E1; CYP2C19; ADH1B; GSTK1; GSTO2
Drug metabolism - other enzymes
DPYD; PNAT3; UGT1A7; UPP1; UGT1AB; UCK2; UPP2; IMPDH1; UGT1A6A; CES1C
Fatty Acid Omega Oxidation
ADH7; CYP2D6; ADH1A; CYP2E1; ADH1C; CYP4A11; CYP2A6; ADH1B; ADH6; CYP1A1

Protein Function

CYP2A6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A6 itself. We selected most functions CYP2A6 had, and list some proteins which have the same functions with CYP2A6. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2C54; CYP4F2; CYP2C8; CYP2P8; CYP2E1; CYP2C38; CYP2B19; CYP2Y3; CYP2D26; CYP2P7
Function coumarin 7-hydroxylase activity
Related Protein CYP2A4; CYP2A6
Function enzyme binding
Related Protein KMT2E; CAD; EIF4E; CREB1; KDM1A; JUN; HNRNPUL1; NR5A1; UGT1A4; GOT2
Function heme binding
Related Protein CYP2U1; NOS3; HBAE1; CYP21A1; NGB; HBB-B2; CYP2K22; CYP2C54; CYP3A4; CYP2N13
Function iron ion binding
Related Protein CYP2K17; CYP7B1; CYGB2; CYP2V1; AOX4; CYP2D6; CYP2D26; CYP2C70; HBB-Y; CYP4F14
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2P10; CYP1A2; CYP2C19; CYP2C39; CYP2A7; CYP2D9; CYP2AA1; CYP19A1; CYP2W1; CYP2P7
Function oxygen binding
Related Protein CYP2C55; HBBE1.1; HBA2; Adgb; CYP2W1; CYP2A4; CYP2F2; CYP2C39; HBA-X; CYP2AA7
Function steroid hydroxylase activity
Related Protein CYP2C55; CYP2C8; CYP2C38; CYP2V1; CYP2AD3; CYP2AA3; CYP2N13; CYP2F2; CYP2B19; CYP46A1.3

CYP2A6 Related Articles

Sliwinska-Mosson, M; Zielen, I; et al. NEW TRENDS IN THE TREATMENT OF NICOTINE ADDICTION. ACTA POLONIAE PHARMACEUTICA 71:525-530(2014).
Pearce, RE; Cohen-Wolkowiez, M; et al. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K-m) Catalyst. DRUG METABOLISM AND DISPOSITION 41:1686-1694(2013).