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CYP2A6

  • Official Full Name

    cytochrome P450, family 2, subfamily A, polypeptide 6

  • Overview

    This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
  • Synonyms

    CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6; CYP2A3, cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 6; cytochrome P450 2A6; CPA6; CYP2A; cytochrome P450(I); cytochrome P450 IIA3; coumarin 7-hydroxylase; xenobiotic;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Assay Kits
  • Human
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mamanlian cells
  • Wheat Germ
  • DYKDDDDK
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2A6-27019TH Recombinant Human CYP2A6 Wheat Germ N/A 100 amino acids
Human CYP2A6-2258H Recombinant Human CYP2A6 Protein, GST-tagged Wheat Germ GST
Human CYP2A6-125H Recombinant Human CYP2A6 Insect Cell N/A
Human CYP2A6-126H Recombinant Human CYP2A6, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP2A6-7117HCL Recombinant Human CYP2A6 293 Cell Lysate HEK293 N/A
Human CYP2A6-01H Recombinant Human CYP2A6 Protein, Flag-tagged Human Cell DYKDDDDK
Human CYP2A6-12H Active Recombinant Human CYP2A6 Protein E.coli
Human CYP2A6-71H Recombinant Human CYP2A6 Protein E. coli
Human CYP2A6-2732H Recombinant Human CYP2A6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYP2A6-2792H Recombinant Human CYP2A6 protein, His&Myc-tagged E.coli His&Myc 29-494aa
Human CYP2A6-8499HFL Recombinant Full Length Human CYP2A6, Flag-tagged Mamanlian cells Flag
Kit-0923 CYP2A6 Blue Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2A6 Related Articles

CYP2A6 involved in several pathways and played different roles in them. We selected most pathways CYP2A6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Caffeine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsUGT1B1;CYP2B6;MTRR;FDX1;CYP2R1;CYP1A2;CYP2U1;CYP2C8;NCOA2
CYP2E1 reactionsCYP2C9;CYP2B6;CYP2A7;CYP2F1;CYP2Y3;CYP2S1;CYP2A6;CYP2C8;CYP2D6
Caffeine metabolismNAT1;PNAT10;CYP1A2;PNAT3;UOX;XDH;Nat3;NAT;NAT2
Chemical carcinogenesisCYP2C39;SULT1A1;SULT1A2;CCBL2;UGT2A2;GSTA5;AHA-1;CYP2E1;CCBL1
Cytochrome P450 - arranged by substrate typeCYP2AD2;CYP21A2;CYP7A1;CYP2A13;CYP3A4;CYP2K22;CYP11B1;CYP2U1;CYP2A7
Drug metabolism - cytochrome P450ADH2-2;ADH6;CYP2D6;GSTK1;ADH1B;CYP2C19;CYP2A6;CYP2C8;ADH1A
Drug metabolism - other enzymesUGT1A1;CDA;Ces2c;TK1;NAT;CES2;Ces2e;IMPDH1B;UCKL1
Fatty Acid Omega OxidationADH1A;ADH1B;ADH4;ADH1C;CYP2D6;CYP4A11;ADH7;CYP2E1;ADH6

CYP2A6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A6 itself. We selected most functions CYP2A6 had, and list some proteins which have the same functions with CYP2A6. You can find most of the proteins on our site.

Function Related Protein
arachidonic acid epoxygenase activityCYP2P6;CYP2C54;CYP4A10;CYP2C39;CYP2C18;CYP2D6;CYP4F18;CYP2AA7;CYP2S1
coumarin 7-hydroxylase activityCYP2A6;CYP2A4
enzyme bindingPAWR;CASC3;KIAA1967;UGT1A4;SIRT3;HSPA2;CBS;ATG3;YWHAE
heme bindingHBBE3;CYP8B1;MPO;CYP2AA7;PTGES2;PTGS2B;CYP17A1;CYP39A1;CYP3A4
iron ion bindingHBBE2;FDX1;OGFOD2;FAM125B;CYP2P6;CYP4F2;PHF8;LEPREL1;CYP11C1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2F1;CYP19A1;CYP2AD6;CYP2AA8;CYP2K17;CYP2D9;CYP2B19;CYP2C55;CYP2R1
oxygen bindingCYP2X8;CYP3A4;CYP2N13;CYP2P8;HBQ1;CYP2AA1;HBA2;CYP2F1;HBAE3
steroid hydroxylase activityCYP2V1;CYP27A1;CYP2C50;CYP2P7;CYP2B19;CYP2D26;CYP2Y3;CYP2U1;CYP2P6

CYP2A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A6.

Sliwinska-Mosson, M; Zielen, I; et al. NEW TRENDS IN THE TREATMENT OF NICOTINE ADDICTION. ACTA POLONIAE PHARMACEUTICA 71:525-530(2014).
Pearce, RE; Cohen-Wolkowiez, M; et al. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K-m) Catalyst. DRUG METABOLISM AND DISPOSITION 41:1686-1694(2013).
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