CYP2A6 Protein, cytochrome P450, family 2, subfamily A, polypeptide 6


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Official Full Name cytochrome P450, family 2, subfamily A, polypeptide 6
Background This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
Synonyms CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6; CYP2A3, cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 6; cytochrome P450 2A6; CPA6; CYP2A; cytochrome P450(I); cytochrome P450 IIA3; coumarin 7-hydroxylase; xenobiotic
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2A6-12H Recombinant Human CYP2A6 Protein E.coli
    Human CYP2A6-125H Recombinant Human CYP2A6 Insect Cell N/A
    Human CYP2A6-126H Recombinant Human CYP2A6, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2A6-2258H Recombinant Human CYP2A6 Protein, GST-tagged Wheat Germ GST
    Human CYP2A6-27019TH Recombinant Human CYP2A6 Wheat Germ N/A
    Human CYP2A6-7117HCL Recombinant Human CYP2A6 293 Cell Lysate HEK293 N/A
    Kit-0923 CYP2A6 Blue Screening Kit N/A

    CYP2A6 involved in several pathways and played different roles in them. We selected most pathways CYP2A6 participated on our site, such as Biological oxidations, CYP2E1 reactions, Caffeine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations DPEP1; MTRR; CYP1A1; CYP2V1; CYP1B1; ABHD14B; CYP1A2; AADAC; GSTK1; CYP2K19
    CYP2E1 reactions CYP2B6; CYP2D6; CYP2F1; CYP2S1; CYP2C9; CYP2A13; CYP2Y3; CYP2A6; CYP2C8; CYP2E1
    Caffeine metabolism PNAT10; UOX; XDH; NAT2; PNAT3; Nat3; CYP1A2; NAT1; NAT; CYP2A6
    Chemical carcinogenesis SULT1A3; FAM84B; CYP2A6; ALDH1A3; CCBL1; ADH1A; UGT2A1; CYP2C19; GSTA5; CYP2C39
    Cytochrome P450 - arranged by substrate type CYP17A1; POMCB; CYP2AD6; CYP4F11; CYP2A13; CYP2C18; CYP3A7; CYP46A1; CYP2S1; CYP2W1
    Drug metabolism - cytochrome P450 ADH2-1; CYP2A6; CYP2D6; CYP2C9; ADH6; CYP3A5; ADH1C; ADH1A; GSTK1; CYP2C8
    Drug metabolism - other enzymes GUSB; IMPDH1; TPMT.1; GMPS; CDA; Ces2c; PNAT3; HPRT1; TPMT; UGT2A3
    Fatty Acid Omega Oxidation ADH1C; ADH7; ADH1B; CYP2A6; CYP2D6; CYP4A11; CYP2E1; ADH6; ADH1A; CYP1A1

    CYP2A6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A6 itself. We selected most functions CYP2A6 had, and list some proteins which have the same functions with CYP2A6. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2P7; CYP4A10; CYP2D9; CYP2N13; CYP2AD6; CYP2C39; CYP2AA1; CYP2C50; CYP2B6; CYP2V1
    coumarin 7-hydroxylase activity CYP2A6; CYP2A4
    enzyme binding YWHAH; PYCARD; CAT; CTNNBL1; TSPAN15; TOP2B; NR5A1; CAV1; DDC; THRB
    heme binding CYP46A1.4; PTGIS; SDHC; CYP2AA4; CYP2X9; CYP1A1; CYP2K18; CYP2U1; HBA-X; CYP2AD3
    iron ion binding CYP2P9; CYP2AA4; CYP2AD6; TPH1; CYP4X1; LEPREL1; CYP24A1; CYP1A2; NOS2; CYGB2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2C70; CYP2K17; CYP2AD2; CYP2AD6; CYP1A2; CYP1D1; CYP2AD3; CYP2E1; CYP2R1; CYP1A
    oxygen binding CYP2C9; HBBE2; CYP2V1; CYP2A6; CYP1A1; CYP2P10; CYP2X9; HBD; HBM; CYP2K17
    steroid hydroxylase activity CYP2V1; CYP2K16; CYP2AD2; CYP2C50; CYP2J5; CYP2AA12; CYP2P7; CYP2P9; CYP2D9; CYP2K17

    CYP2A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A6.

    Pearce, RE; Cohen-Wolkowiez, M; et al. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K-m) Catalyst. DRUG METABOLISM AND DISPOSITION 41:1686-1694(2013).

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