CYP2A7 Protein, cytochrome P450, family 2, subfamily A, polypeptide 7

CYP2A7

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CYP2A7

Official Full Name cytochrome P450, family 2, subfamily A, polypeptide 7
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms CYP2A7; cytochrome P450, family 2, subfamily A, polypeptide 7; cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 7; cytochrome P450 2A7; CYP2A; CP2A7_HUMAN; CPA7; CPAD; CYP2A 7; CYPIIA7; Cytochrome P450 IIA4; P450 IIA4; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; P450-IIA4
    • Species :
    • Human
    • Source :
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2A7-2259H Recombinant Human CYP2A7 Protein, GST-tagged Wheat Germ GST
    Human CYP2A7-7115HCL Recombinant Human CYP2A7 293 Cell Lysate HEK293 N/A
    Human CYP2A7-7116HCL Recombinant Human CYP2A7 293 Cell Lysate HEK293 N/A

    CYP2A7 involved in several pathways and played different roles in them. We selected most pathways CYP2A7 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations COMT; CYP46A1; CYP2C19; NCOA2; CYP2E1; CYP27B1; POMCB; ADH4; CYP3A4; CYP7A1
    CYP2E1 reactions CYP2Y3; CYP2C9; CYP2C8; CYP2D6; CYP2B6; CYP2S1; CYP2A7; CYP2A13; CYP2F1; CYP2A6
    Cytochrome P450 - arranged by substrate type CYP24A1; CYP2A6; CYP2A7; CYP2AD6; CYP4F22; CYP2U1; FAM84B; CYP11B2; CYP2J2; CYP1B1
    Fatty acids CYP2D6; CYP2A7; CYP2F1; CYP2V1; CYP4T8; CYP2AD6; CYP2N13; CYP4F12; CYP4F22; CYP4A11
    Metabolism SLC25A12; THEM5; ACOT13; CYP2AD3; SLC26A2; CPNE3; HS3ST4; CKBA; SLC25A32B; TIMMDC1
    Phase 1 - Functionalization of compounds CYP2U1; CYP3A7; CYP2K6; CYP2AD3; CYP2A7; CYP2K17; CYP2AD2; CYP4F12; CYP27B1; CYP4T8
    Xenobiotics CYP3C4; CYP3C1; CYP2W1; CYP2A7
    cytochrome P450 CYP2W1; CYP4Z1; CYB5R3; CYP20A1; CYB5A; CYP4V2; CYP2A7; CYB5B; POR; CYP4F12

    CYP2A7 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A7 itself. We selected most functions CYP2A7 had, and list some proteins which have the same functions with CYP2A7. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2C37; CYP2S1; CYP2C70; CYP2P7; CYP2B6; CYP2V1; CYP2N13; CYP2C39; CYP2C50; CYP2C54
    aromatase activity CYP3A7; CYP2B19; CYP2D26; CYP1A4; CYP2D10; CYP3A5; CYP4A12A; CYP2U1; CYP2H1; CYP2A13
    heme binding HBB; PTGS2B; CYP2C50; CYP17A2; CYP2N13; HBQ1; CYP2K18; CYP1A4; CYP2A6; CYP2F2
    iron ion binding CH25H; CYP2AA3; BA1; CYP2K16; P4HA3; CYP3A25; HBB-B2; CYP2V1; EGLN1; P4HA1A
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2A7; CYP2AA12; CYP2AA7; CYP2C55; CYP1D1; CYP19A1; CYP2D26; CYP2AA4; CYP2AA9; CYP3A25
    oxygen binding BA1; CYP2AA7; CYP2D9; CYP2D6; CYP4B1; TDO2; FAM84B; CYP2K16; CYP2K6; HBB-BH1
    steroid hydroxylase activity CYP46A1.4; CYP2C55; CYP2J5; CYP2AA7; CYP2A7; CYP2C8; CYP2R1; CYP2AD2; CYP2AA8; CYP2A13

    CYP2A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A7.

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