CYP2B6 Protein, cytochrome P450, family 2, subfamily B, polypeptide 6


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Official Full Name cytochrome P450, family 2, subfamily B, polypeptide 6
Background This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CYP2B, cytochrome P450, family 2, subfamily B , cytochrome P450, subfamily IIB (phenobarbital inducible) , cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6; cytochrome P450 2B6; CPB6; CYPIIB6; 11B1; CP2B6_HUMAN; CPB 6; CYP 2B6; CYP IIB6; CYP2B; CYP2B7; CYP2B7P; Cytochrome P450 family 2 subfamily B; Cytochrome P450 family 2 subfamily B polypeptide 6; Cytochrome P450 IIB1; Cytochrome P450 phenobarbital inducible; Cytochrome P450 subfamily IIB (phenobarbital inducible); Cytochrome P450 subfamily IIB (phenobarbital inducible) polypeptide 6; Cytochrome P450 subfamily IIB polypeptide 6; IIB1; P450; P450 IIB1; P450IIB1; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2B6-21H Recombinant Human CYP2B6 Protein E.coli
    Human CYP2B6-22H Recombinant Human CYP2B6 Protein E.coli
    Human CYP2B6-16H Recombinant Human CYP2B6 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2B6-17H Recombinant Human CYP2B6 protein, GST-tagged Wheat Germ GST
    Human CYP2B6-192H Recombinant Human CYP2B6 Mammalian Cell His
    Human CYP2B6-231H Recombinant Human CYP2B6 Insect Cell N/A
    Human CYP2B6-28193TH Recombinant Human CYP2B6 Wheat Germ N/A
    Cynomolgus Monkey CYP2B6-439C Recombinant Cynomolgus CYP2B6 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CYP2B6-1146R Recombinant Rhesus monkey CYP2B6 Protein, His-tagged Mammalian Cell His
    Kit-0917 CYP2B6 Blue Screening Kit N/A
    Kit-1943 CYP2B6 Induction Reporter Assay Kit N/A

    CYP2B6 involved in several pathways and played different roles in them. We selected most pathways CYP2B6 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2B6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism PLA2G12A; GPX7; PTGDS; CYP2J2; CYP4F14; CYP2N13; CYP1B1; CYP2P10; CYP2C8; CYP2U1
    Biological oxidations UGT1B7; SULT1C4; CYP2C8; MTRR; BPNT1; UGT1B4; CYP17A1; CYP2AD3; CYP21A2; CYP2D6
    CYP2E1 reactions CYP2C19; CYP2C8; CYP2F1; CYP2E1; CYP2Y3; CYP2C9; CYP2D6; CYP2A13; CYP2S1; CYP2B6
    Cytochrome P450 - arranged by substrate type CYP2K16; CYP19A1; CYP4F22; CYP11B2; CYP2V1; CYP4B1; CYP3A7-CYP3AP1; CYP2A6; CYP2A7; CYP26A1
    Drug metabolism - cytochrome P450 CYP2C9; CYP2E1; ADH1A; CYP2C19; ADH7; ADH2-2; ADH5; GSTO2; CYP2A6; CYP2C8
    Fatty acids CYP2A7; CYP2N13; CYP2D6; CYP2A13; CYP4B1; CYP4F22; CYP2F1; CYP2AD2; CYP4F11; CYP4F12
    Metabolic pathways HIBCH; HSD11B1; SMPD5; HMGCS1; CERS2; CYP2P7; AMY2A3; PRPS1A; NOS2B; AGXT
    Metabolism VAPB; CYP4T8; KCNG4; ACER1; HPSE; ALDH9A1A.2; ACOT13; CYP3C1; ADA; PITPNB

    CYP2B6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2B6 itself. We selected most functions CYP2B6 had, and list some proteins which have the same functions with CYP2B6. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2A7; CYP2J5; CYP2C9; CYP2AA12; CYP2P8; CYP2D6; CYP4A11; CYP2AA2; CYP2AA3; CYP4F18
    heme binding CYP8B3; HBB-B2; CYP2P8; CYP4B1; DGCR8; CYP4F11; CYP4X1; CYP2AA4; HBAA1; CYP2C39
    iron ion binding CYP19A1B; TPH1B; CYP2F1; TMEM195; CYP2C55; CYP2U1; CYP2D9; CYP3A4; CYP2C54; NOS2B
    monooxygenase activity CYP46A1.3; CYP2P6; YWHAE1; CYP2AA3; CYP4A12A; CYP2C39; CYP2F1; CYP2K16; MICAL2; CYP2AA6
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2F2; CYP2C8; CYP2C19; CYP2P8; CYP2U1; CYP2J5; CYP2P6; CYP2E1; CYP2D26; CYP2S1
    oxygen binding HBG1; CYP2AA9; NGB; CYP2C19; CYP2E1; HBA2; CYP3A4; HBB-BH1; CYP2B6; CYP2C70
    steroid hydroxylase activity CYP2K22; CYP2AD3; CYP2P10; CYP2C8; CYP2D26; CYP2E1; CYP2AA7; CYP2B6; FAM84B; CYP2C38

    CYP2B6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2B6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2B6.

    Liu, ZH; Li, L; et al. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo. DRUG METABOLISM AND DISPOSITION 43:208-216(2015).
    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

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