CYP2C9

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CYP2C9

Official Full Name cytochrome P450, family 2, subfamily C, polypeptide 9
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Synonyms CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9; CPC9; CYP2C; CYP2C10; CYPIIC9; MGC88320; P450IIC9; MGC149605; cytochrome P450 2C9; OTTHUMP00000020135; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase
    • Species :
    • Cynomolgus
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • P.pastoris
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus CYP2C9-125C Recombinant Cynomolgus CYP2C9 Protein E. coli
    Human CYP2C9-22H Recombinant Human CYP2C9 Protein E.coli
    Human CYP2C9-74H Recombinant Human CYP2C9 Protein E. coli
    Human CYP2C9-35H Recombinant Human CYP2C9/NADPH reductase protein P.pastoris N/A
    Human CYP2C9-530H Recombinant Human CYP2C9, GST-tagged Wheat Germ GST
    Human CYP2C9-531H Recombinant Human CYP2C9 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2C9-537H Recombinant Human CYP2C9 Insect Cell N/A
    Human CYP2C9-543H Recombinant Human CYP2C9 1(Wild type allele) E.coli N/A
    Human CYP2C9-544H Recombinant Human CYP2C9 2 (R144C) E.coli N/A
    Human CYP2C9-545H Recombinant Human CYP2C9 3 (I359L) E.coli N/A
    Human CYP2C9-7113HCL Recombinant Human CYP2C9 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CYP2C9-1151R Recombinant Rhesus monkey CYP2C9 Protein, His-tagged Mammalian Cell His
    Kit-0898 CYP2C9 Green Screening Kit N/A
    Kit-0915 CYP2C9 Blue Screening Kit N/A
    Kit-0936 CYP2C9 Red Screening Kit N/A
    Kit-1944 CYP2C9 Induction Reporter Assay Kit N/A
    Kit-2116 Cytochrome P450 2C9 Activity Fluorometric Assay Kit N/A
    Kit-2117 Cytochrome P450 2C9 Inhibitor Screening Kit N/A

    CYP2C9 involved in several pathways and played different roles in them. We selected most pathways CYP2C9 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonate Epoxygenase / Epoxide Hydrolase CYP2C9; CYP2J2; COX8A
    Arachidonic acid metabolism CYP2P8; GGT5; LTC4S; CYP2C45; LTA4H; PTGES; MAPKAPK2B; HPGDS; CYP1A2; ALOX5B.2
    Biological oxidations CYP2K16; SULT2ST2; DPEP2; ACY3.2; SULT1ST6; DPEP1; CYP46A1; ABHD14B; CYP2A13; CYP4T8
    CYP2E1 reactions CYP2C9; CYP2S1; CYP2C8; CYP2D6; CYP2A13; CYP2A6; CYP2C19; CYP2E1; CYP2B6; CYP2A7
    Chemical carcinogenesis ADH1; GSTM4; CYP2C39; CYP2C50; CYP2C37; CYP2C9; ADH5; ADH1A; ADH1B; CYP2A13
    Cytochrome P450 - arranged by substrate type POMCB; CYP3C4; CYP2K6; CYP2J2; CYP3C1; CYP2A13; CYP4A11; CYP2K8; CYP51A1; FDXR
    Drug metabolism - cytochrome P450 CYP3A5; GSTK1; CYP2B6; ADH2-1; CYP2A6; CYP2D6; ADH5; ADH6; ADH1A; ADH7
    Linoleic acid metabolism PLA2G4A; CYP2P9; PLA2G6; PLA2G2F; PLA2G4AA; PLA2G4D; PLA2G12A; CYP2J2; DHRS13L1; CYP3A41B

    CYP2C9 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C9 itself. We selected most functions CYP2C9 had, and list some proteins which have the same functions with CYP2C9. You can find most of the proteins on our site.

    Function Related Protein
    (R)-limonene 6-monooxygenase activity CYP2C9; CYP2C8; CYP2C19
    (S)-limonene 6-monooxygenase activity CYP2C9; CYP2C8; CYP2C19
    (S)-limonene 7-monooxygenase activity CYP2C8; CYP2C19; CYP2C9
    arachidonic acid epoxygenase activity CYP2B6; CYP2C70; CYP2C50; CYP2C37; CYP4F12; CYP2A4; CYP2J6; CYP2S1; CYP2D10; CYP2A6
    aromatase activity CYP2J5; CYP2C9; CYP2D6; CYP2F1; CYP2A7; CYP2C55; CYP19A1; CYP2J6; CYP2C70; CYP1A
    caffeine oxidase activity CYP2C39; FAM84B; CYP2C38; CYP2C9; CYP1A2; CYP3A4
    drug binding GPR30; PNP; PDE10A; HMGB2; TYMS; PDE2A; HTR2C; NR1I2; CHRNB4; GLRB
    heme binding CYP2J2; CYP2AA12; CYP46A1.4; STC2; CYP2C54; CYP3A4; CYP2S1; Adgb; CBSA; CYP2X10.2
    iron ion binding CALR; CYP2K17; CYP4A10; CYP1A; TMLHE; MTRR; PLOD3; C14orf169; CYP26A1; EGLN1B
    monooxygenase activity BCO1; TPH1B; MOXD1L; CYP3A5; BCMO1; CYP2AA7; CYP2C8; CYP4F22; CYP3A4; CYP1C2
    oxidoreductase activity HSDL2; SPRA; CYB561A3A; DHRS12; CYP2D9; HMGCRA; KDM1A; TESCA; GCDHB; CYP2J5
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2F2; CYP2K6; CYP1B1; CYP2AA9; CYP2AA8; CYP2A6; CYP2C8; CYP2P6; CYP2D9; CYP2X9
    oxygen binding CYP2C38; HBD; CYP2B6; CYP2X8; CYP2D26; CYP2X9; XGB; CYP2C8; CYP2AA8; CYP1A1
    steroid hydroxylase activity CYP2AD2; CYP2B6; CYP2AA9; BRSK2; CYP2AA3; CYP2C18; CYP2A12; CYP2AA4; CYP2R1; CYP2D9

    CYP2C9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C9.

    STAMBP; RAB3D; STAT5A; CDC37; RNF32; MAST1

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).

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