CYP2C9 Protein, cytochrome P450, family 2, subfamily C, polypeptide 9

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CYP2C9

Official Full Name	cytochrome P450, family 2, subfamily C, polypeptide 9
Background	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Synonyms	CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9; CPC9; CYP2C; CYP2C10; CYPIIC9; MGC88320; P450IIC9; MGC149605; cytochrome P450 2C9; OTTHUMP00000020135; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase

Species :
Cynomolgus
Human
Rhesus Macaque

Source :
E. coli
E.coli
HEK293
Insect Cell
Mammalian Cell
P.pastoris
Wheat Germ

Tag :
GST
His
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag
Cynomolgus	CYP2C9-125C	Recombinant Cynomolgus CYP2C9 Protein	E. coli
Human	CYP2C9-22H	Recombinant Human CYP2C9 Protein	E.coli
Human	CYP2C9-74H	Recombinant Human CYP2C9 Protein	E. coli
Human	CYP2C9-35H	Recombinant Human CYP2C9/NADPH reductase protein	P.pastoris	N/A
Human	CYP2C9-530H	Recombinant Human CYP2C9, GST-tagged	Wheat Germ	GST
Human	CYP2C9-531H	Recombinant Human CYP2C9 protein, MYC/DDK-tagged	HEK293	Myc/DDK
Human	CYP2C9-537H	Recombinant Human CYP2C9	Insect Cell	N/A
Human	CYP2C9-543H	Recombinant Human CYP2C9 1(Wild type allele)	E.coli	N/A
Human	CYP2C9-544H	Recombinant Human CYP2C9 2 (R144C)	E.coli	N/A
Human	CYP2C9-545H	Recombinant Human CYP2C9 3 (I359L)	E.coli	N/A
Human	CYP2C9-7113HCL	Recombinant Human CYP2C9 293 Cell Lysate	HEK293	N/A
Rhesus Macaque	CYP2C9-1151R	Recombinant Rhesus monkey CYP2C9 Protein, His-tagged	Mammalian Cell	His
	Kit-0898	CYP2C9 Green Screening Kit		N/A
	Kit-0915	CYP2C9 Blue Screening Kit		N/A
	Kit-0936	CYP2C9 Red Screening Kit		N/A
	Kit-1944	CYP2C9 Induction Reporter Assay Kit		N/A
	Kit-2116	Cytochrome P450 2C9 Activity Fluorometric Assay Kit		N/A
	Kit-2117	Cytochrome P450 2C9 Inhibitor Screening Kit		N/A

Involved Pathway Protein Function Interacting Protein CYP2C9 Related Articles

CYP2C9 involved in several pathways and played different roles in them. We selected most pathways CYP2C9 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonate Epoxygenase / Epoxide Hydrolase	CYP2C9; CYP2J2; COX8A
Arachidonic acid metabolism	CYP2P8; GGT5; LTC4S; CYP2C45; LTA4H; PTGES; MAPKAPK2B; HPGDS; CYP1A2; ALOX5B.2
Biological oxidations	CYP2K16; SULT2ST2; DPEP2; ACY3.2; SULT1ST6; DPEP1; CYP46A1; ABHD14B; CYP2A13; CYP4T8
CYP2E1 reactions	CYP2C9; CYP2S1; CYP2C8; CYP2D6; CYP2A13; CYP2A6; CYP2C19; CYP2E1; CYP2B6; CYP2A7
Chemical carcinogenesis	ADH1; GSTM4; CYP2C39; CYP2C50; CYP2C37; CYP2C9; ADH5; ADH1A; ADH1B; CYP2A13
Cytochrome P450 - arranged by substrate type	POMCB; CYP3C4; CYP2K6; CYP2J2; CYP3C1; CYP2A13; CYP4A11; CYP2K8; CYP51A1; FDXR
Drug metabolism - cytochrome P450	CYP3A5; GSTK1; CYP2B6; ADH2-1; CYP2A6; CYP2D6; ADH5; ADH6; ADH1A; ADH7
Linoleic acid metabolism	PLA2G4A; CYP2P9; PLA2G6; PLA2G2F; PLA2G4AA; PLA2G4D; PLA2G12A; CYP2J2; DHRS13L1; CYP3A41B

CYP2C9 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C9 itself. We selected most functions CYP2C9 had, and list some proteins which have the same functions with CYP2C9. You can find most of the proteins on our site.

Function	Related Protein
(R)-limonene 6-monooxygenase activity	CYP2C9; CYP2C8; CYP2C19
(S)-limonene 6-monooxygenase activity	CYP2C9; CYP2C8; CYP2C19
(S)-limonene 7-monooxygenase activity	CYP2C8; CYP2C19; CYP2C9
arachidonic acid epoxygenase activity	CYP2B6; CYP2C70; CYP2C50; CYP2C37; CYP4F12; CYP2A4; CYP2J6; CYP2S1; CYP2D10; CYP2A6
aromatase activity	CYP2J5; CYP2C9; CYP2D6; CYP2F1; CYP2A7; CYP2C55; CYP19A1; CYP2J6; CYP2C70; CYP1A
caffeine oxidase activity	CYP2C39; FAM84B; CYP2C38; CYP2C9; CYP1A2; CYP3A4
drug binding	GPR30; PNP; PDE10A; HMGB2; TYMS; PDE2A; HTR2C; NR1I2; CHRNB4; GLRB
heme binding	CYP2J2; CYP2AA12; CYP46A1.4; STC2; CYP2C54; CYP3A4; CYP2S1; Adgb; CBSA; CYP2X10.2
iron ion binding	CALR; CYP2K17; CYP4A10; CYP1A; TMLHE; MTRR; PLOD3; C14orf169; CYP26A1; EGLN1B
monooxygenase activity	BCO1; TPH1B; MOXD1L; CYP3A5; BCMO1; CYP2AA7; CYP2C8; CYP4F22; CYP3A4; CYP1C2
oxidoreductase activity	HSDL2; SPRA; CYB561A3A; DHRS12; CYP2D9; HMGCRA; KDM1A; TESCA; GCDHB; CYP2J5
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2F2; CYP2K6; CYP1B1; CYP2AA9; CYP2AA8; CYP2A6; CYP2C8; CYP2P6; CYP2D9; CYP2X9
oxygen binding	CYP2C38; HBD; CYP2B6; CYP2X8; CYP2D26; CYP2X9; XGB; CYP2C8; CYP2AA8; CYP1A1
steroid hydroxylase activity	CYP2AD2; CYP2B6; CYP2AA9; BRSK2; CYP2AA3; CYP2C18; CYP2A12; CYP2AA4; CYP2R1; CYP2D9

CYP2C9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C9.

STAMBP; RAB3D; STAT5A; CDC37; RNF32; MAST1

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).

CYP2C9

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CYP2C9

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