cyp2c9
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 9
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
  • Synonyms
  • CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9; CPC9; CYP2C; CYP2C10; CYPIIC9; MGC88320; P450IIC9; MGC149605; cytochrome P450 2C9; OTTHUMP00000020135; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase
Cat.#:CYP2C9-35HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human CYP2C9/NADPH reductase protein
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Cat.#:CYP2C9-530HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP2C9, GST-tagged
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Cat.#:CYP2C9-531HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2C9 protein, MYC/DDK-tagged
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Cat.#:CYP2C9-537HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2C9
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Cat.#:CYP2C9-543HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C9 1(Wild type allele)
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Cat.#:CYP2C9-544HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C9 2 (R144C)
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Cat.#:CYP2C9-545HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C9 3 (I359L)
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Cat.#:CYP2C9-1151RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C9 Protein, His-tagged
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Cat.#:CYP2C9-7113HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2C9 293 Cell Lysate
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Cat.#:Kit-2116Tag:
Source (Host):Species:
Product nameCytochrome P450 2C9 Activity Fluorometric Assay Kit
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Cat.#:Kit-2117Tag:
Source (Host):Species:
Product nameCytochrome P450 2C9 Inhibitor Screening Kit
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Cat.#:Kit-1944Tag:
Source (Host):Species:
Product nameCYP2C9 Induction Reporter Assay Kit
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Cat.#:Kit-0898Tag:
Source (Host):Species:
Product nameCYP2C9 Green Screening Kit
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Cat.#:Kit-0915Tag:
Source (Host):Species:
Product nameCYP2C9 Blue Screening Kit
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Cat.#:Kit-0936Tag:
Source (Host):Species:
Product nameCYP2C9 Red Screening Kit
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Involved Pathway

CYP2C9 involved in several pathways and played different roles in them. We selected most pathways CYP2C9 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonate Epoxygenase / Epoxide Hydrolase
CYP2J2; COX8A; CYP2C9
Arachidonic acid metabolism
CYP2P6; PTGS1; CYP1A2; CYP2AD6; ALOX5B.2; PTGR1; CYP2P7; PLA2G10; PTGDSB; CYP2P9
Biological oxidations
CYP2F1; FDX1L; GLYAT; CYP3A7; Sult2a2; SULT4A1; CYP4F12; ABHD10; NAT2; GLYATL2
CYP2E1 reactions
CYP2C19; CYP2C8; CYP2F1; CYP2E1; CYP2B6; CYP2S1; CYP2A13; CYP2Y3; CYP2A6; CYP2D6
Chemical carcinogenesis
UGT2A1; MGST1; CYP2C50; PTGS2; UGT1A2; ADH5; ADH1A; UGT2B15; CYP2E1; CYP2C8
Cytochrome P450 - arranged by substrate type
CYP19A1; CYP2D6; CYP46A1; CYP4T8; FDX1; CYP11B1; CYP2K18; CYP2K22; CYP2C18; CYP17A1
Drug metabolism - cytochrome P450
GSTO2; ADH2-2; CYP2C9; CYP3A5; GSTK1; ADH4; CYP2D6; ADH7; ADH2-1; ADH1B
Linoleic acid metabolism
CYP2P8; PLB1; CYP2C8; CYP2J5; CYP2C19; CYP2P10; CYP2P7; PLA2G5; CYP2C55; PLA2G4AA

Protein Function

CYP2C9 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C9 itself. We selected most functions CYP2C9 had, and list some proteins which have the same functions with CYP2C9. You can find most of the proteins on our site.
Function
Related Protein
Function (R)-limonene 6-monooxygenase activity
Related Protein CYP2C19; CYP2C9; CYP2C8
Function (S)-limonene 6-monooxygenase activity
Related Protein CYP2C9; CYP2C19; CYP2C8
Function (S)-limonene 7-monooxygenase activity
Related Protein CYP2C19; CYP2C8; CYP2C9
Function arachidonic acid epoxygenase activity
Related Protein CYP2AA3; CYP4A11; CYP2C8; CYP2B19; CYP2AA1; CYP2AD6; CYP2AD2; CYP2C19; CYP2C55; CYP2C9
Function aromatase activity
Related Protein CYP4Z1; CYP2A7; FAM84B; CYP3A4; CYP2J5; CYP3A7; CYP4B1; CYP2S1; CYP2U1; CYP2F1
Function caffeine oxidase activity
Related Protein CYP2C38; CYP3A4; CYP2C9; FAM84B; CYP2C39; CYP1A2
Function drug binding
Related Protein PPP3CB; DRD3; FOLR2; HTR1B; CYP2C9; PPARD; ACE; HTR2B; CHRM1; DHFR
Function heme binding
Related Protein CYGB2; MPX; CYP2F1; MPO; CYP46A1.1; CYP2X9; CYP2J5; CBSA; CYP3C1L2; CYP17A2
Function iron ion binding
Related Protein P4HTM; CYP2P7; CYP7A1A; FDX1; LEPREL1; P4HA2; SC5DL; CYP2P9; CYP2A13; NOS2
Function monooxygenase activity
Related Protein CYP2AD3; CYP4F14; CYP2X8; CYP19A1B; CYP2X9; CYP2A12; CYP2D6; CYP2P6; CYP2X7; COQ6
Function oxidoreductase activity
Related Protein HADHAA; AOX4; SPRA; AKR1A1B; GPD1A; SPRB; ZADH2; GULO; ALDH9A1B; Akr1b3
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2K16; CYP2J5; CYP2C50; CYP2C19; CYP2E1; CYP2F1; CYP1A2; CYP2AA8; CYP3A25; CYP2V1
Function oxygen binding
Related Protein CYP2AA9; CYP2P9; CYP2C55; XGB; CYP2D10; CYP2C8; CYP2A4; CYGB2; HBQ1; CYP2D6
Function steroid hydroxylase activity
Related Protein CYP2K18; CYP2B6; CYP2K6; CYP2D6; CYP2P6; CYP27A1; CYP2F2; CYP2A6; CYP2K17; CYP2AA12

Interacting Protein

CYP2C9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C9.
STAMBP; RAB3D; STAT5A; CDC37; RNF32; MAST1

CYP2C9 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).