CYP2F1 Protein, CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 [ Homo sapiens ]

CYP2F1

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CYP2F1

Official Full Name CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 [ Homo sapiens ]
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms CYPIIF1; Cytochrome P450 2F1; cytochrome P450, family 2, subfamily F, polypeptide 1; EC=1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; EC 1.14.14.1; xenobiotic monooxygenase
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2F1-11776H Recombinant Human CYP2F1, GST-tagged E.coli GST
    Human CYP2F1-2267H Recombinant Human CYP2F1 Protein, GST-tagged Wheat Germ GST
    Rhesus Macaque CYP2F1-1155R Recombinant Rhesus monkey CYP2F1 Protein, His-tagged Mammalian Cell His

    CYP2F1 involved in several pathways and played different roles in them. We selected most pathways CYP2F1 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP2K17; CYP2V1; CYP2A7; CYP24A1; CYP2C8; PRKRA; CYP4T8; SULT1C4; CYP4F11; CYP11B2
    CYP2E1 reactions CYP2C9; CYP2E1; CYP2A6; CYP2C8; CYP2B6; CYP2S1; CYP2D6; CYP2Y3; CYP2A7; CYP2F1
    Cytochrome P450 - arranged by substrate type CYP2A6; CYP3A4; CYP3C1; CYP17A1; CYP3C4; FAM84B; CYP4B1; CYP3A7; FDXR; CYP4F22
    Fatty acids CYP4F12; CYP4B1; CYP2D6; CYP2B6; CYP2AD3; CYP2J2; CYP2A7; CYP2AD6; CYP2AD2; CYP2V1
    Metabolism DDAH2; KCNS3; FAM213B; NDOR1; CHAT; DDAH1; PDK3B; CYP2A7; FIG4; GC
    Metabolism of xenobiotics by cytochrome P450 CYP2F1; AKR1C4; PRKRA; AKR1C2; ADH2-2; GSTK1; CYP2S1; ADH2-1
    Phase 1 - Functionalization of compounds CYP27B1; CYP2AD2; CYP2R1; CYP3C1; CYP2V1; CYP2Y3; CYP26A1; CYP3C4; CYP3A7-CYP3AP1; CYP2K17
    Tryptophan metabolism CCBL1; CYP2F1; IL4I1; GCDHB; RNF25; OGDHL; AANAT2; MAOA; AADAT; ABP1

    CYP2F1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2F1 itself. We selected most functions CYP2F1 had, and list some proteins which have the same functions with CYP2F1. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2A4; CYP2A13; CYP4A11; CYP2C55; CYP2AA2; CYP2A12; CYP4F18; CYP2E1; CYP2C38; CYP2C9
    aromatase activity CYP2C39; CYP2B19; CYP1B1; CYP2U1; CYP2J2; CYP2C54; CYP4B1; CYP1A2; CYP2D10; CYP2C38
    heme binding BA1; JAK2; NENF; CYP27B1; CYP2C50; CYP2R1; CBSA; TDO2; CYP2B19; ABCB6
    iron ion binding CYP51A1; ALOX12E; HIF1AN; CYP3C4; CYP2K17; POR; CYP4T8; HBA-X; CYP1C2; CYP2AD6
    monooxygenase activity CYP2C70; YWHABL; CYP4A14; CYP2F1; CYP19A1A; CYP1A1; FAM84B; CYP8B2; CYP46A1.3; CYP4T8
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2P9; CYP2P8; CYP2AA8; CYP2AD2; CYP2AD3; CYP2C50; CYP2J6; CYP3C1; CYP2C54; CYP2D9
    oxygen binding CYP1A4; FAM84B; CYP2X7; HBAD; HBE1; CYP2C54; HBB; HBBE2; CYP2E1; CYP2C37
    steroid hydroxylase activity CYP2S1; CYP2AA4; CYP27A1; CYP2C39; CYP2AA2; CYP21A2; CYP2K6; BRSK2; CYP46A1; CYP46A1.3

    CYP2F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2F1.

    Chen, PC; Syu, GD; et al. Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays. MOLECULAR & CELLULAR PROTEOMICS 14:510-518(2015).
    Kull, S; Schulz, KM; et al. Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype. PLOS ONE 10:-(2015).

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