CYP2J2

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CYP2J2

Official Full Name cytochrome P450, family 2, subfamily J, polypeptide 2
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
Synonyms CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2; CPJ2; cytochrome P450 2J2; CYPIIJ2; microsomal monooxygenase; arachidonic acid epoxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2;
    • Species :
    • Human
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2J2-47H Recombinant Human CYP2J2 Protein E.coli
    Human CYP2J2-80H Recombinant Human CYP2J2 Protein E. coli
    Human CYP2J2-2268H Recombinant Human CYP2J2 Protein, GST-tagged Wheat Germ GST
    Human CYP2J2-7110HCL Recombinant Human CYP2J2 293 Cell Lysate HEK293 N/A
    Kit-0914 CYP2J2 Cyan Screening Kit N/A

    CYP2J2 involved in several pathways and played different roles in them. We selected most pathways CYP2J2 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonate Epoxygenase / Epoxide Hydrolase CYP2J2; CYP2C9; COX8A
    Arachidonic acid metabolism GPX8; GPX5; CYP4A11; CYP2J6; CYP4F18; PTGES3; GGT5; PTGES; AKR1C6; GGTLC1
    Biological oxidations CYP4T8; CYP2S1; UGT1B3; CYP1A2; CYP2K17; CYP2R1; ACY3.1; SLC26A1; DPEP2; PRKRA
    Cytochrome P450 - arranged by substrate type CYP2N13; CYP17A1; CYP3A5; CYP2Y3; CYP2AD6; CYP51A1; CYP2K8; CYP2AD2; CYP2U1; CYP2S1
    Fatty acids CYP2AD6; CYP4F22; CYP2A7; CYP2J2; CYP2AD3; CYP2B6; CYP4A11; CYP2N13; CYP2V1; CYP2F1
    Inflammatory mediator regulation of TRP channels CAMK2A; PPP1CC; IL1B; CALM2; PLA2G4A; PRKCA; HRH1; ALOX12E; CALML3; KLK1B4
    Linoleic acid metabolism PLA2G12A; CYP2C9; PLA2G1B; PLA2G4AA; CYP2C8; CYP2P9; CYP3A41B; CYP3A65; CYP2C19; CYP3A41A
    Metabolic pathways ATP6V0C; OTC; CTPS2; IMPDH1B; ALOX15B; UROD; MTMR1; MCCC1; NDUFS4; MPST

    CYP2J2 has several biochemical functions, for example, arachidonic acid 11,12-epoxygenase activity, arachidonic acid 14,15-epoxygenase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2J2 itself. We selected most functions CYP2J2 had, and list some proteins which have the same functions with CYP2J2. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid 11,12-epoxygenase activity CYP2J6; CYP2J2
    arachidonic acid 14,15-epoxygenase activity CYP2J6; CYP2J2
    arachidonic acid epoxygenase activity CYP2AA8; CYP2D6; CYP2D9; CYP2C39; CYP2P9; CYP2C37; CYP2C55; CYP2A12; CYP2AA7; CYP2F2
    aromatase activity CYP2C9; CYP19A1; CYP3A43; CYP2C37; CYP1A2; CYP4Z1; CYP1D1; FAM84B; CYP2D6; CYP2A12
    heme binding PTGIS; CYP11A1; CBSB; CYP4F3; CYP2AD2; XGB; CYP3A43; CYP4F12; CYP2X8; HBD
    iron ion binding CYP7A1A; ALOX5B.3; CYP51; CYP2J6; FAXDC2; CYP2K16; CYP1A2; PLOD3; CYP2A6; CYP2AA7
    linoleic acid epoxygenase activity CYP2J6; CYP2C54; CYP2C50; CYP2C55; CYP2J2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2AA4; CYP2J5; CYP2AA6; CYP2J6; CYP2J2; CYP2R1; CYP2C8; CYP2P9; CYP2C38; CYP2C9
    oxygen binding HBG2; CYP2C54; CYGB1; CYP2AD6; CYP2AA3; HBAE1; CYP2X7; CYP2K16; CYP2K17; CYP2X8
    steroid hydroxylase activity CYP2P8; CYP2C39; CYP2C37; CYP2AA4; CYP2R1; CYP2F2; CYP2B19; CYP2AA1; CYP2V1; CYP21A2

    CYP2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2J2.

    ZBTB25; TCEB1

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).

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