CYP2J2
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Official Full Name
cytochrome P450, family 2, subfamily J, polypeptide 2 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008] -
Synonyms
CYP2J2;cytochrome P450, family 2, subfamily J, polypeptide 2;CPJ2;cytochrome P450 2J2;CYPIIJ2;microsomal monooxygenase;arachidonic acid epoxygenase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2J2-2268H | Recombinant Human CYP2J2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP2J2-7110HCL | Recombinant Human CYP2J2 293 Cell Lysate | HEK293 | Human | Non |
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| CYP2J2-47H | Active Recombinant Human CYP2J2 Protein | E.coli | Human |
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| CYP2J2-80H | Recombinant Human CYP2J2 Protein | E.coli | Human |
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| Kit-0914 | CYP2J2 Cyan Screening Kit | Non |
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Involved Pathway
CYP2J2 involved in several pathways and played different roles in them. We selected most pathways CYP2J2 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase,Arachidonic acid metabolism,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | PLCB3,PRKACB,PLCB4,ITPR3,PRKCQ,MAPK9,CAMK2D,MAPK10,IL1B,PPP1CC |
| Arachidonic acid metabolism | GPX8,CBR1,DPEP1,CYP2AD3,GPX6,CYP2AD2,PLA2G6,CYP2C54,CBR2,CYP1A1 |
| Linoleic acid metabolism | CYP2P10,CYP2C50,PLA2G4F,PLA2G12A,CYP2C70,CYP2P6,PLA2G4D,CYP2C55,PLB1,PLA2G12B |
| Biological oxidations | SULT1ST6,CYP2C9,SULT1C2,ACSM1,GLYATL2,CYP2AD3,UGT1B3,CYP2K6,ACY3.2,ACY3.1 |
| Fatty acids | CYP2A13,CYP2AD3,CYP4B1,CYP2D6,CYP2N13,CYP4F12,CYP2A7,CYP2AD6,CYP4F22,CYP2B6 |
| Cytochrome P450 - arranged by substrate type | CYP2W1,CYP2Y3,CYP4B1,CYP3A7,CYP2E1,CYP17A1,FDX1,CYP2C18,CYP4F11,CYP2C9 |
| Arachidonate Epoxygenase / Epoxide Hydrolase | CYP2C9,COX8A |
| Metabolic pathways | DCK,ALDH2,POLR3G,DGAT2,PNPLA2,GALC,ACO2,AGXTB,COX10,ATP6V0A4 |
Protein Function
CYP2J2 has several biochemical functions, for example, arachidonic acid 11,12-epoxygenase activity,arachidonic acid 14,15-epoxygenase activity,arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2J2 itself. We selected most functions CYP2J2 had, and list some proteins which have the same functions with CYP2J2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| linoleic acid epoxygenase activity | CYP2C50,CYP2C54,CYP2C55,CYP2J6 |
| arachidonic acid epoxygenase activity | CYP2C50,CYP2V1,CYP2P6,CYP2S1,CYP2A12,CYP2AA7,CYP2N13,CYP2J5,CYP2B19,CYP2C70 |
| steroid hydroxylase activity | CYP27A1,CYP3A4,CYP2K16,CYP2B6,CYP2A6,CYP2E1,CYP2C8,CYP2C54,CYP46A1.2,CYP2AA7 |
| oxygen binding | CYP2C50,CYP2E1,HBE,CYP2AA3,CYP2F1,CYP2C18,CYP2AA1,HBAA1,CYP3A4,TH |
| heme binding | CYP19A1,NR1D1,PTGS2,CYP7B1,CYP4F14,CYP2C37,CYP1D1,CYP2AA2,GUCY1A3,JAK2 |
| iron ion binding | CYP2D6,CYP4A12A,TYW1B,CYP2V1,CYP2A12,ALOX5,PPEF1,CYP8B1,HBAD,POR |
| arachidonic acid 11,12-epoxygenase activity | CYP2J6 |
| arachidonic acid 14,15-epoxygenase activity | CYP2J6 |
| aromatase activity | CYP3A7,CYP2D26,CYP2C37,CYP2D9,CYP2J5,CYP4Z1,CYP4F12,CYP2B19,CYP2D10,CYP2S1 |
Interacting Protein
CYP2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2J2.
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References
- Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
