cyp2j2
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  • Official Full Name
  • cytochrome P450, family 2, subfamily J, polypeptide 2
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2; CPJ2; cytochrome P450 2J2; CYPIIJ2; microsomal monooxygenase; arachidonic acid epoxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2;
Cat.#:CYP2J2-2268HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2J2 Protein, GST-tagged
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Cat.#:CYP2J2-7110HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2J2 293 Cell Lysate
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Cat.#:Kit-0914Tag:
Source (Host):Species:
Product nameCYP2J2 Cyan Screening Kit
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Involved Pathway

CYP2J2 involved in several pathways and played different roles in them. We selected most pathways CYP2J2 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonate Epoxygenase / Epoxide Hydrolase
COX8A; CYP2J2; CYP2C9
Arachidonic acid metabolism
CYP2P8; CYP1A1; PLA2G2A; PTGDSA; CYP2C8; ALOX5A; EPHX2; CYP4A14; ALOX15B; ALOX8
Biological oxidations
SULT2ST2; SLC35B3; CYP21A2; CYP17A1; CYP3A7-CYP3AP1; ABHD14B; CYP4A11; CYP11B1; UGT1B2; CYP4F12
Cytochrome P450 - arranged by substrate type
CYP27A1; CYP2A7; CYP24A1; CYP3C4; CYP3A5; CYP2AD6; CYP3A7; CYP2K6; CYP2B6; CYP2K22
Fatty acids
CYP2B6; CYP2AD3; CYP4F12; CYP2A7; CYP4T8; CYP2N13; CYP2V1; CYP4F22; CYP2F1; CYP4F11
Inflammatory mediator regulation of TRP channels
CAMK2D; TRPA1; CALML3; PLCG1; IL1R1; CYP2J6; NGF; PRKCA; PRKCE; ASIC1
Linoleic acid metabolism
CYP2C37; CYP3A41A; CYP2C9; CYP2C70; PLA2G10; PLB1; PLA2G1B; CYP2C39; PLA2G4F; DHRS13L1
Metabolic pathways
NDUFS4; GLULB; ALG10; MOCS2; LDHAL6A; RIMKLB; MGAT5B; POLR2E; B3GNT5B; ETNK2

Protein Function

CYP2J2 has several biochemical functions, for example, arachidonic acid 11,12-epoxygenase activity, arachidonic acid 14,15-epoxygenase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2J2 itself. We selected most functions CYP2J2 had, and list some proteins which have the same functions with CYP2J2. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid 11,12-epoxygenase activity
Related Protein CYP2J2; CYP2J6
Function arachidonic acid 14,15-epoxygenase activity
Related Protein CYP2J6; CYP2J2
Function arachidonic acid epoxygenase activity
Related Protein CYP4A11; CYP2V1; CYP2AA3; CYP2AA4; CYP2S1; CYP2C38; CYP2AD2; CYP2Y3; CYP2F2; CYP2AD3
Function aromatase activity
Related Protein CYP4A12A; CYP19A1; CYP2D10; CYP1A1; CYP1B1; CYP3A4; CYP2C54; CYP4F12; CYP2C37; CYP2F1
Function heme binding
Related Protein HBM; Adgb; CYP7A1A; CYP2AA6; DUOX2; CYP17A1; CYP39A1; HBG1; CYP17A2; CYP21A1
Function iron ion binding
Related Protein CYP2P10; SC5DL; HBE; CYP51A1; CYP2X8; AOX3; AOX1; CYP46A1.2; CYP2X7; EGLN1
Function linoleic acid epoxygenase activity
Related Protein CYP2J6; CYP2C54; CYP2C55; CYP2J2; CYP2C50
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2C54; CYP2X9; CYP2D10; CYP2X10.2; CYP2P10; CYP2E1; CYP2AD3; CYP2X8; CYP2S1; CYP2C19
Function oxygen binding
Related Protein CYP2V1; HBD; CYP2A12; CYP17A1; HBE; XGB; HBA2; HBBE2; HBA1; CYP2X8
Function steroid hydroxylase activity
Related Protein CYP2AA12; CYP2C38; CYP2K22; CYP2C70; CYP2AA2; CYP2AA7; CYP2AD3; CYP46A1.2; CYP2AD2; CYP2AD6

Interacting Protein

CYP2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2J2.
ZBTB25; TCEB1

CYP2J2 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).