CYP2S1
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Official Full Name
cytochrome P450, family 2, subfamily S, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. -
Synonyms
CYP2S1;cytochrome P450, family 2, subfamily S, polypeptide 1;cytochrome P450, subfamily IIS, polypeptide 1;cytochrome P450 2S1;CYPIIS1;cytochrome P540, subfamily IIS, polypeptide 1;cytochrome P450 family member predicted from ESTs
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2S1-4201M | Recombinant Mouse CYP2S1 Protein | Mammalian Cells | Mouse | His |
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| CYP2S1-7108HCL | Recombinant Human CYP2S1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP2S1-1451HFL | Recombinant Full Length Human CYP2S1 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| CYP2S1-2150M | Recombinant Mouse CYP2S1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CYP2S1-2150M-B | Recombinant Mouse CYP2S1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Cyp2s1-2419M | Recombinant Mouse Cyp2s1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| CYP2S1-704H | Recombinant Human CYP2S1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| CYP2S1-704H-B | Recombinant Human CYP2S1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
CYP2S1 involved in several pathways and played different roles in them. We selected most pathways CYP2S1 participated on our site, such as Biological oxidations,CYP2E1 reactions,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Miscellaneous substrates | CYP2K16,CYP2K17,CYP2K19,CYP2K22,CYP2U1,CYP2K6,CYP4F22,CYP4F11,CYP2K18,CYP3C4 |
| Metabolism | DECR1,CTGF,AGPAT6,SLC5A6A,CYP17A1,CHKB,ACOT10,CDK19,ABHD10,NQO1 |
| Biological oxidations | SLC35B3,Sult2a2,DPEP2,ACY3.2,SULT1B1,ACY3.1,CYP21A2,SLC35D1A,CYP2C18,CYP2AD3 |
| Cytochrome P450 - arranged by substrate type | CYP2C9,CYP8B2,CYP2K17,CYP2A7,CYP2K16,CYP1A1,CYP27B1,CYP3A7-CYP3AP1,CYP2AD3,CYP2A13 |
| Phase 1 - Functionalization of compounds | ADH8A,AADAC,CYP2K8,CYP2W1,CYP2K6,CYP2R1,CYP4T8,CYP2U1,CES1,CYP27B1 |
| Metabolism of xenobiotics by cytochrome P450 | AKR1C2,ADH2-2,AKR1C4,CYP2F1,ADH2-1,PRKRA,GSTK1 |
| Metabolic pathways | PIP5K1AB,COX7C,PPAP2CB,ACOT2,CYP4A12A,MGAT3,ALDH1A1,ATP6V0E1,SPS2,PIGP |
| CYP2E1 reactions | CYP2A6,CYP2B6,CYP2A7,CYP2C9,CYP2F1,CYP2C8,CYP2A13,CYP2D6,CYP2E1,CYP2C19 |
Protein Function
CYP2S1 has several biochemical functions, for example, arachidonic acid epoxygenase activity,aromatase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2S1 itself. We selected most functions CYP2S1 had, and list some proteins which have the same functions with CYP2S1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxygen binding | HBZ,CYP2C54,CYP2X9,CYP2J5,CYGB,CYP2K6,CYP2C70,CYP3A7,CYP2F1,HBAE1 |
| arachidonic acid epoxygenase activity | CYP2P10,CYP2P7,CYP2AA1,CYP2B6,CYP2A4,CYP2E1,CYP2V1,CYP2D10,CYP4F2,CYP2F2 |
| iron ion binding | CYP2J2,HBG1,CYP2B6,CH25H,CYP2X8,CYP2E1,PHF2,CYP2J5,ALOX15B,CYP2K19 |
| heme binding | CYP46A1.3,CYP2W1,CYP4V7,CYP46A1.1,HEBP1,CYP2C8,CYP46A1,CYP2C18,CYP2D9,HBA1 |
| protein binding | RRM2B,IL7R,ODF1,CDON,C19orf57,DALRD3,SWAP70,MYBPC1,PPP1R37,SGOL2 |
| aromatase activity | CYP19A1,CYP2B19,CYP3A43,CYP1A2,CYP4X1,CYP2C70,CYP2C55,CYP1A,FAM84B,CYP1A1 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2K17,CYP2B6,CYP2A6,CYP19A1,CYP2C70,CYP2U1,CYP2C19,CYP2AA3,CYP2R1,CYP2K18 |
| steroid hydroxylase activity | CYP2U1,CYP2AA3,CYP2R1,CYP2X9,BRSK2,CYP2AA4,CYP2C54,CYP46A1.2,CYP2B19,CYP2K19 |
Interacting Protein
CYP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2S1.
ADAMTSL4;ADAMTSL4
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