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CYP2S1

Official Full Name

cytochrome P450, family 2, subfamily S, polypeptide 1
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.
Synonyms

CYP2S1; cytochrome P450, family 2, subfamily S, polypeptide 1; cytochrome P450, subfamily IIS, polypeptide 1; cytochrome P450 2S1; CYPIIS1; cytochrome P540, subfamily IIS, polypeptide 1; cytochrome P450 family member predicted from ESTs;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	CYP2S1-7108HCL	Recombinant Human CYP2S1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	CYP2S1-1451HFL	Recombinant Full Length Human CYP2S1 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	CYP2S1-704H-B	Recombinant Human CYP2S1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	CYP2S1-704H	Recombinant Human CYP2S1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	CYP2S1-4201M	Recombinant Mouse CYP2S1 Protein	Mammalian Cell	His	Inquiry
Mouse	CYP2S1-2150M	Recombinant Mouse CYP2S1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Cyp2s1-2419M	Recombinant Mouse Cyp2s1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	CYP2S1-2150M-B	Recombinant Mouse CYP2S1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP2S1 involved in several pathways and played different roles in them. We selected most pathways CYP2S1 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Biological oxidations	UGT1B1;CYP27B1;SULT1C2;CYP4F11;ADH6;CYP27A1;AKR1A1;CYP2K6;SULT1ST6
CYP2E1 reactions	CYP2Y3;CYP2A13;CYP2C8;CYP2C19;CYP2D6;CYP2C9;CYP2A7;CYP2S1;CYP2A6
Cytochrome P450 - arranged by substrate type	CYP2R1;CYP4F22;CYP2N13;CYP2B6;CYP2A13;CYP2K22;CYP2E1;CYP46A1;CYP2S1
Metabolic pathways	DGAT1A;CKMT2B;HYAL4;SGMS2;ATP6V1E1;COMTA;DHCR24;CDA;ALPL
Metabolism	AZIN1;CLPS;NUDT3A;ACOT7;SACM1L;CYGB;APOEA;COX6A1;BPNT1
Metabolism of xenobiotics by cytochrome P450	GSTK1;ADH2-2;ADH2-1;AKR1C4;CYP2S1;PRKRA;AKR1C2;CYP2F1
Miscellaneous substrates	CYP2K17;CYP2K19;CYP2K6;CYP2U1;CYP2K22;CYP4F22;CYP4B1;CYP2S1;CYP2K16
Phase 1 - Functionalization of compounds	CYP2R1;CYP2K22;CYP2S1;CYP2K19;CYP2K17;CYP26A1;CYP4F12;ADH8A;CYP3C4

CYP2S1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2S1 itself. We selected most functions CYP2S1 had, and list some proteins which have the same functions with CYP2S1. You can find most of the proteins on our site.

Function	Related Protein
arachidonic acid epoxygenase activity	CYP2E1;CYP2D26;CYP2AA9;CYP4F18;CYP2P6;CYP2A6;CYP2AA7;CYP2B19;CYP2C55
aromatase activity	CYP1D1;CYP3A7;CYP1A1;CYP3A5;CYP1A4;CYP2C54;CYP2J2;CYP2H1;CYP19A1
heme binding	FECH;HBBE1.1;CYP39A1;MFSD7C;CYP2J2;CYP2K22;CAT;CYP4F2;SUOX
iron ion binding	P4HA3;CYP2F1;CYP2AA7;CYP46A1.2;CYP26C1;CYP17A2;CYP4V2;CYP1D1;CYP4F12
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2F1;CYP2B19;CYP2K22;CYP2C55;CYP2A4;CYP2P10;CYP2C18;CYP2AA3;CYP2AA7
oxygen binding	CYP2X9;CYP2A13;CYP2AA8;CYP26A1;CYP1A1;HBD;HBAA;CYP2AD2;CYP3A4
protein binding	ANXA7;DPYSL5;IRAK2;TNFAIP8;ROPN1B;PIP5K1C;SRF;MAP4K5;MATN4
steroid hydroxylase activity	CYP2X7;CYP2D10;CYP2K18;CYP2B6;CYP2P9;CYP2N13;CYP2F1;CYP2AA4;CYP2K16

CYP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2S1.

ADAMTSL4; ADAMTSL4