cyp2s1
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  • Official Full Name
  • cytochrome P450, family 2, subfamily S, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.
  • Synonyms
  • CYP2S1; cytochrome P450, family 2, subfamily S, polypeptide 1; cytochrome P450, subfamily IIS, polypeptide 1; cytochrome P450 2S1; CYPIIS1; cytochrome P540, subfamily IIS, polypeptide 1; cytochrome P450 family member predicted from ESTs
Cat.#:CYP2S1-4201MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP2S1 Protein
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Cat.#:CYP2S1-7108HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP2S1 293 Cell Lysate
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Involved Pathway

CYP2S1 involved in several pathways and played different roles in them. We selected most pathways CYP2S1 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CES1; CYP2U1; ACY3.2; ADH1A; CYP46A1; ACSM1; ABHD14B; FDX1; CYP11B2; SULT1ST6
CYP2E1 reactions
CYP2C9; CYP2A6; CYP2A13; CYP2Y3; CYP2C19; CYP2S1; CYP2B6; CYP2A7; CYP2F1; CYP2E1
Cytochrome P450 - arranged by substrate type
CYP2N13; CYP17A1; CYP3A7; FDX1L; CYP2AD3; CYP26A1; CYP2C19; FDXR; CYP8B2; CYP2U1
Metabolic pathways
PYGMA; B3GNT3; DHRS9; ATP6V0A4; COX8C; PHYKPL; ACOX1; CHIA.2; CBR3; GALNT5
Metabolism
SLC25A16; BRP44; NUDT4B; GLTPA; CPNE6; PPM1K; IDO2; PAICS; ARL2BP; GLYATL1
Metabolism of xenobiotics by cytochrome P450
CYP2S1; ADH2-2; ADH2-1; AKR1C2; AKR1C4; PRKRA; CYP2F1; GSTK1
Miscellaneous substrates
CYP2K17; CYP4F22; CYP2S1; CYP3C1; CYP4B1; CYP2U1; CYP2W1; CYP3C4; CYP2K22; CYP2K18
Phase 1 - Functionalization of compounds
CYP2K17; ADH8A; CYP2K16; CYP4F12; CYP4T8; CYP2K8; CYP2F1; CYP26A1; CYP8B2; CYP3C4

Protein Function

CYP2S1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2S1 itself. We selected most functions CYP2S1 had, and list some proteins which have the same functions with CYP2S1. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2S1; CYP2AA1; CYP2D9; CYP2A6; CYP2AA3; CYP4F18; CYP2B6; CYP2A13; CYP2C50; CYP2AA9
Function aromatase activity
Related Protein CYP2D9; CYP3A7; CYP2C50; CYP2J6; CYP2S1; CYP3A43; CYP2D10; CYP2D6; CYP4X1; CYP2J5
Function heme binding
Related Protein GUCY1A3; PTGS2B; DUOX2; MPX; CYP2H1; CYP2B19; CYP46A1.2; CYP2C39; CYP3C1; CYP8B3
Function iron ion binding
Related Protein CYP2AA9; CYP46A1.4; XDH; CYP19A1B; NOS2B; CYP2AA6; ALOX12B; CYP2C38; CYP2K19; CH25HL2
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2J5; CYP2P6; CYP2P7; CYP2K18; CYP2C55; CYP2A6; CYP2E1; CYP3A25; CYP1D1; CYP2AA6
Function oxygen binding
Related Protein CYP2C54; CYP2AA2; CYP26A1; CYP2W1; CYP2P6; HBQ1; CYP2P10; HBA2; HBAA1; CYP2AA8
Function protein binding
Related Protein LARP4; CDK16; ZFP57; RPS11; NUDT4; GTF3C5; BCL3; FBXO45; PKP2; LEMD3
Function steroid hydroxylase activity
Related Protein CYP2X8; CYP27A1; CYP2X9; CYP46A1.4; CYP2AA8; CYP2A12; CYP2AA4; CYP2C50; CYP2C19; CH25H

Interacting Protein

CYP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2S1.
ADAMTSL4; ADAMTSL4