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CYP4A11

  • Official Full Name

    cytochrome P450, family 4, subfamily A, polypeptide 11

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11; CP4Y; CYP4A2; CYP4AII; cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP4A11-11787H Recombinant Human CYP4A11, GST-tagged E.coli GST N-term-215a.a.
Human CYP4A11-2280H Recombinant Human CYP4A11 Protein, GST-tagged Wheat Germ GST
Human CYP4A11-26692TH Recombinant Human CYP4A11 Wheat Germ N/A 216 amino acids
Human CYP4A11-439HCL Recombinant Human CYP4A11 cell lysate N/A
Human CYP4A11-84H Active Recombinant Human CYP4A11 Protein E. coli
Human CYP4A11-73H Active Recombinant Human CYP4A11 Protein E.coli
Human CYP4A11-107HF Recombinant Full Length Human CYP4A11 Protein In Vitro Cell Free System 216 amino acids
Human CYP4A11-2440HF Recombinant Full Length Human CYP4A11 Protein, GST-tagged In Vitro Cell Free System GST 215 amino acids
Cynomolgus Monkey CYP4A11-445C Recombinant Cynomolgus CYP4A11 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CYP4A11-191C Recombinant Cynomolgus Monkey CYP4A11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CYP4A11-191C-B Recombinant Cynomolgus Monkey CYP4A11 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP4A11 Related Articles

CYP4A11 involved in several pathways and played different roles in them. We selected most pathways CYP4A11 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismLTA4H;PLA2G4A;PTGDSA;GPX3;CYP2P10;FAAH2A;PLA2G2E;ALOX15B;CBR2
Biological oxidationsADH6;CYP2N13;CYP2B6;SULT2ST2;CYP2U1;FAM84B;CYP8B2;ADH5;CYP3A7-CYP3AP1
Cytochrome P450 - arranged by substrate typeCYP4A11;CYP2A13;CYP2K16;CYP11A1;CYP2A7;FDX1;CYP2S1;CYP2K8;CYP4T8
EicosanoidsCYP4B1;CYP4A11;CYP4F22;CYP4F12;CYP4F11
Fatty Acid Omega OxidationCYP2A6;CYP2D6;ADH7;ADH6;ADH1A;CYP1A1;ADH1B;CYP2E1;CYP4A11
Fatty acid degradationCYP4A10;ALDH2.1;ADH6;HADH;ACOX3;CYP4A12A;ECI2;ALDH9A1B;HADHAA
Fatty acid, triacylglycerol, and ketone body metabolismACOT11A;HELZ2;ELOVL1A;MED26;ACSF3;SLC25A20;AGPAT1;ESRRA;APOA5
Fatty acidsCYP2A13;CYP2AD6;CYP4F22;CYP2J2;CYP2AD2;CYP4F12;CYP4B1;CYP2A7;CYP2V1

CYP4A11 has several biochemical functions, for example, alkane 1-monooxygenase activity, arachidonic acid epoxygenase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4A11 itself. We selected most functions CYP4A11 had, and list some proteins which have the same functions with CYP4A11. You can find most of the proteins on our site.

Function Related Protein
alkane 1-monooxygenase activityCYP4F12;CYP4A10;CYP4A12A;CYP4A11;CYP4F2;CYP4A14;CYP4F18
arachidonic acid epoxygenase activityCYP2C55;CYP2D26;CYP2A4;CYP2AD6;CYP2J6;CYP2C54;CYP2AA4;CYP2N13;CYP2F1
heme bindingCYP2A13;CYP8B3;PTGESL;CYP4A11;SDHD;CYP51;CYP4X1;CYP46A1.4;CYP1B1
iron ion bindingALOX15B;ALOX5B.3;CYP2C70;CYP2AA2;CYP1C2;PPEF1;TYW1B;CYP27B1;CYP2E1
leukotriene-B4 20-monooxygenase activityCYP4F12;CYP4F14;CYP4F18;CYP4A10;CYP4F3;CYP4A11;CYP4F2

CYP4A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4A11.

PIK3R5

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Chen, L; Ackerman, R; et al. 20-HETE Regulates the Angiogenic Functions of Human Endothelial Progenitor Cells and Contributes to Angiogenesis In Vivo. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 348:442-451(2014).
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