cyp4b1
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  • Official Full Name
  • cytochrome P450, family 4, subfamily B, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene.
  • Synonyms
  • CYP4B1; cytochrome P450, family 4, subfamily B, polypeptide 1; cytochrome P450, subfamily IVB, polypeptide 1; cytochrome P450 4B1; CP4B1_HUMAN; CYPIVB1; Cytochrome P450-HP; P450HP; microsomal monooxygenase; P-450HP
Cat.#:CYP4B1-2281HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP4B1 Protein, GST-tagged
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Cat.#:CYP4B1-1749RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP4B1 Protein
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Cat.#:CYP4B1-7104HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP4B1 293 Cell Lysate
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Involved Pathway

CYP4B1 involved in several pathways and played different roles in them. We selected most pathways CYP4B1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
PTGES3; HPGDS; TBXAS1; ALOX15; PLA2G16; CYP2P9; GPX3; PLA2G12B; CYP4F11; CYP1A2
Biological oxidations
CYP21A2; AS3MT; NCOA2; UGT1B5; ADH1C; CYP2C8; CYP1A2; COMT; ADH4; ADH5
Cytochrome P450 - arranged by substrate type
CYP4A11; CYP2R1; CYP2V1; CYP19A1; CYP2C8; CYP2A7; CYP1A1; CYP4B1; CYP2Y3; CYP2J2
Eicosanoids
CYP4A11; CYP4F12; CYP4F11; CYP4F22; CYP4B1
Fatty acids
CYP4B1; CYP2AD6; CYP2AD2; CYP4A11; CYP4F11; CYP2B6; CYP2J2; CYP2A13; CYP2F1; CYP2V1
Metabolism
CYP2S1; PPM1LA; GLIPR1; PDP2; COX15; SLC35D2; PLB1; MPC1; SLC25A16; ACSF3
Metabolism of lipids and lipoproteins
SLC27A2; MED10; AKR1C2; CPTP; BRSK2; VAPB; MED20; CYP2V1; ARSE; CLPS
Miscellaneous substrates
CYP2K17; CYP4F22; CYP2S1; CYP2U1; CYP3C4; CYP2K19; CYP2K16; CYP4B1; CYP2K22; CYP3C1

Protein Function

CYP4B1 has several biochemical functions, for example, aromatase activity, drug binding, fluorene oxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4B1 itself. We selected most functions CYP4B1 had, and list some proteins which have the same functions with CYP4B1. You can find most of the proteins on our site.
Function
Related Protein
Function aromatase activity
Related Protein CYP3A5; CYP1A2; CYP2C18; CYP2U1; CYP3A43; CYP2A12; CYP2C54; CYP4B1; CYP2J6; CYP4A12A
Function drug binding
Related Protein CHRM3; PDXK; CNR1; PPP3CA; ADH1; SIGMAR1; PDE4C; HTR2A; PDE10A; HMGCS1
Function fluorene oxygenase activity
Related Protein DEGS1; CYP4B1
Function heme binding
Related Protein CYP4A11; CYP2V1; HBA-X; BACH1; CBS; ABCB6; SRC; CYP2R1; CYP46A1.2; CYP7B1
Function iron ion binding
Related Protein CYP2AD3; CYP2AA12; CYP3A43; CYP2K19; HBE1; ALOX15; CYP2C9; NDOR1; TYW5; CYP7A1
Function oxygen binding
Related Protein CYP2AA9; CYP2F2; CYP19A1; HBAE3; HBA2; CYP2A13; CYP2D26; HBQ1; CYP2K6; HBAA

Interacting Protein

CYP4B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4B1.
DFFA

CYP4B1 Related Articles

Milic, NL; Ngo, SNT; et al. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 153:60-66(2011).
Dorrenhaus, A; Muller, T; et al. Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. ARCHIVES OF TOXICOLOGY 81:19-25(2007).