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CYP4F2

Official Full Name

cytochrome P450, family 4, subfamily F, polypeptide 2
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
Synonyms

CYP4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; leukotriene-B(4) omega-hydroxylase 1; CYPIVF2; cytochrome P450 4F2; cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase; leukotriene B4 om;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP4F2-555H	Active Recombinant Human CYP4F2	Insect Cell	N/A		Inquiry
Human	CYP4F2-10H	Active Recombinant Human CYP4F2 Protein	E.coli			Inquiry
Human	CYP4F2-85H	Recombinant Human CYP4F2 Protein	E. coli			Inquiry
Human	CYP4F2-301409H	Recombinant Human CYP4F2 protein, GST-tagged	E.coli	GST	Met251-Thr324	Inquiry
Human	CYP4F2-1302H	Recombinant Human CYP4F2 Protein, His-tagged	E.coli	N-His	Met1-Asp252	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CYP4F2 Related Articles

CYP4F2 involved in several pathways and played different roles in them. We selected most pathways CYP4F2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonic acid metabolism	PTGS1;GPX5;ALOX5;FAAH2B;FAM213B;CYP2P7;PTGES3B;CYP2C19;CBR1L
Metabolic pathways	ALPI;PFKMB;GALCA;GBA3;DGKAA;UPP1;ATIC;RDH10A;MDH1AA

CYP4F2 has several biochemical functions, for example, alkane 1-monooxygenase activity, alpha-tocopherol omega-hydroxylase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F2 itself. We selected most functions CYP4F2 had, and list some proteins which have the same functions with CYP4F2. You can find most of the proteins on our site.

Function	Related Protein
alkane 1-monooxygenase activity	CYP4A14;CYP4A11;CYP4F18;CYP4A12A;CYP4F12;CYP4F2;CYP4A10
alpha-tocopherol omega-hydroxylase activity	CYP4F3;CYP4F14;CYP4F18;CYP4F2
arachidonic acid epoxygenase activity	CYP2C70;CYP4A10;CYP2S1;CYP2C9;CYP2B19;CYP2C38;CYP2C50;CYP2F1;CYP2A13
arachidonic acid omega-hydroxylase activity	CYP4F18;CYP4A14;CYP4F2;CYP4A10
heme binding	CYP3A5;CYB5A;HBG1;CYP2C55;CYP17A2;CYP2C50;CYP2Y3;CYP2AA6;FA2H
iron ion binding	NOS3;Agmo;C14orf169;BBOX1;HBA2;AOX4;JHDM1D;CH25H;CYP2J6
leukotriene-B4 20-monooxygenase activity	CYP4F12;CYP4F2;CYP4A10;CYP4F14;CYP4F3;CYP4A11;CYP4F18
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F2;CYP11A1;COQ6;MICAL1;MTRR;NDOR1;CYP11B2;CYP4F11;MICAL2
protein binding	FOXO1;DCP1B;TET2;SGTB;CLSTN1;CYP4F2;HSPA1B;ZFP143;COG1
tocotrienol omega-hydroxylase activity	CYP4F2;CYP4F18;MICAL2;MICAL2B

CYP4F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F2.

ABL1; FYN; SRC; NCK1; GRB2

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

Michaels, S; Wang, MZ; et al. The Revised Human Liver Cytochrome P450 "Pie": Absolute Protein Quantification of CYP4F and CYP3A Enzymes Using Targeted Quantitative Proteomics. DRUG METABOLISM AND DISPOSITION 42:1241-1251(2014).