cyp4f2
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  • Official Full Name
  • cytochrome P450, family 4, subfamily F, polypeptide 2
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
  • Synonyms
  • CYP4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; leukotriene-B(4) omega-hydroxylase 1; CYPIVF2; cytochrome P450 4F2; cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase; leukotriene B4 om
Cat.#:CYP4F2-555HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP4F2
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Involved Pathway

CYP4F2 involved in several pathways and played different roles in them. We selected most pathways CYP4F2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2J2; GGTLC1; CYP2N13; AKR1C3; PLA2G10; PTGS2B; GGT5A; LTC4S; CYP1A1; GPX7
Metabolic pathways
MOGAT3; INPP5A; TKTL2; ALDH2.1; DUT; PAH; NDUFS1; AK5; PIGW; CYP21A2

Protein Function

CYP4F2 has several biochemical functions, for example, alkane 1-monooxygenase activity, alpha-tocopherol omega-hydroxylase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F2 itself. We selected most functions CYP4F2 had, and list some proteins which have the same functions with CYP4F2. You can find most of the proteins on our site.
Function
Related Protein
Function alkane 1-monooxygenase activity
Related Protein CYP4A11; CYP4F2; CYP4F12; CYP4A10; CYP4A12A; CYP4A14; CYP4F18
Function alpha-tocopherol omega-hydroxylase activity
Related Protein CYP4F14; CYP4F18; CYP4F3; CYP4F2
Function arachidonic acid epoxygenase activity
Related Protein CYP2C37; CYP4A11; CYP2AA8; CYP4F2; CYP2Y3; CYP2AA9; CYP2C18; CYP2B6; CYP2C9; CYP2P9
Function arachidonic acid omega-hydroxylase activity
Related Protein CYP4F2; CYP4A10; CYP4F18; CYP4A14
Function heme binding
Related Protein CYP2AA12; IDO2; CYP46A1.3; CBSA; PGRMC1; CYP24A1; PTGIS; CYP26B1; MPO; PXDN
Function iron ion binding
Related Protein CYP4F11; CYP2K16; HBA2; EGLN1B; ALOX5B.2; CYP21A1; TYW1; CYP4F2; HBAE3; CYP2AD3
Function leukotriene-B4 20-monooxygenase activity
Related Protein CYP4A10; CYP4F14; CYP4F2; CYP4F12; CYP4A11; CYP4F18; CYP4F3
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Related Protein CYP4F11; CYP11C1; MTRR; MICAL1; CYP11A1; NDOR1; CYP11B1; CYP4F2; MICAL2; COQ6
Function protein binding
Related Protein AGAP2; DR1; KLRC1; ASAP1; ADPRH; RAB9B; MUC7; MUTED; PLEKHM1; ZAP70
Function tocotrienol omega-hydroxylase activity
Related Protein CYP4F2; CYP4F18; MICAL2; MICAL2B

Interacting Protein

CYP4F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F2.
ABL1; FYN; SRC; NCK1; GRB2

CYP4F2 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Michaels, S; Wang, MZ; et al. The Revised Human Liver Cytochrome P450 "Pie": Absolute Protein Quantification of CYP4F and CYP3A Enzymes Using Targeted Quantitative Proteomics. DRUG METABOLISM AND DISPOSITION 42:1241-1251(2014).