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CYP4F22

  • Official Full Name

    cytochrome P450, family 4, subfamily F, polypeptide 22

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3.
  • Synonyms

    CYP4F22; cytochrome P450, family 4, subfamily F, polypeptide 22; cytochrome P450 4F22; FLJ39501; CP4FN_HUMAN; FLJ 39501; LI3; cytochrome P450, family 2, subfamily E, polypeptide 2 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP4F22-2284H Recombinant Human CYP4F22 Protein, GST-tagged Wheat Germ GST
Human CYP4F22-7101HCL Recombinant Human CYP4F22 293 Cell Lysate HEK293 N/A
Human CYP4F22-2444HF Recombinant Full Length Human CYP4F22 Protein, GST-tagged In Vitro Cell Free System GST 531 amino acids
Human CYP4F22-5879H Recombinant Human CYP4F22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Rhesus Macaque CYP4F22-1163R Recombinant Rhesus monkey CYP4F22 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP4F22-988R Recombinant Rhesus Macaque CYP4F22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYP4F22-988R-B Recombinant Rhesus Macaque CYP4F22 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYP4F22 involved in several pathways and played different roles in them. We selected most pathways CYP4F22 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP4F14;GPX8;ALOX12;PTGES3A;PLB1;GPX1A;PTGS2B;CBR1L;AKR1C6
Biological oxidationsFDXR;CYP11A1;SLC26A2;ADH1C;AHCY;SLC26A1;CYP2B6;CYP2A6;CYP2AD6
Cytochrome P450 - arranged by substrate typeCYP2V1;CYP2W1;CYP21A2;CYP8B2;CYP4T8;CYP2AD2;CYP3A7-CYP3AP1;CYP17A1;FAM84B
EicosanoidsCYP4F12;CYP4F22;CYP4B1;CYP4F11;CYP4A11
Fatty acidsCYP4B1;CYP2AD2;CYP2D6;CYP2J2;CYP4A11;CYP4F11;CYP4F12;CYP4T8;CYP2B6
MetabolismGPHNA;CYP51A1;CPTP;SLC25A2;COQ7;ABHD3;COX6A1;AZIN1;TACO1
Metabolism of lipids and lipoproteinsMTP;SLC44A5B;CYP46A1;G0S2;EBP;Alb;GLTP;ARSJ;PLBD1
Miscellaneous substratesCYP2K19;CYP3C1;CYP2K16;CYP2K8;CYP2U1;CYP4F22;CYP2K22;CYP2W1;CYP4B1

CYP4F22 has several biochemical functions, for example, heme binding, iron ion binding, monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F22 itself. We selected most functions CYP4F22 had, and list some proteins which have the same functions with CYP4F22. You can find most of the proteins on our site.

Function Related Protein
heme bindingCYP2A6;CYP2P8;TDO2A;CYP2D9;CYP2P7;CYP2X9;PTGS1;CYP2K17;CYP27C1
iron ion bindingCYP2D9;CH25HL2;EGLN1;CYP11A1;AOX4;MTRR;XDH;HBQ1;CYP2AD6
monooxygenase activityCYP2C19;CYP2B6;CYP26C1;CYP2D10;CYP3C1;CYP2D9;CYP2K6;CYP2K17;CYP1B1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenCYP26C1;CYP2V1;CYP51;CYP4T8;CYP2AD3;CYP46A1.2;CYP2D9;CYP2AA3;CYP2A12

CYP4F22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F22.

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