cacnb4
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  • Official Full Name
  • Calcium Channel, Voltage-Dependent, Beta 4 Subunit
  • Background
  • Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. Specifically, this gene encodes a member of the β subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α1, α3/δ, β, andγ subunits in a 1:1:1:1 ratio. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling theα1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
  • Synonyms
  • CACNB4; Cavβ4 Calcium Channel; EA5; EJM; calcium channel, voltage-dependent, beta 4 subunit; CAB4; EIG9; EJM4; EJM6; CACNLB4; voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207228; OTTHUMP00000207246; OTTHUMP00000207247; OTTHUMP00000207248; OTTHUMP00000207249; OTTHUMP00000209460
Cat.#:CACNB4-0274HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CACNB4 Protein, GST-Tagged
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Cat.#:CACNB4-10640HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CACNB4, His-tagged
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Cat.#:CACNB4-603RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CACNB4 Protein, His-tagged
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Cat.#:CACNB4-1136CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CACNB4
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Cat.#:CACNB4-5916CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CACNB4
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Cat.#:CACNB4-7902HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CACNB4 293 Cell Lysate
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Involved Pathway

Cacnb4 involved in several pathways and played different roles in them. We selected most pathways Cacnb4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cacnb4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RPS6KA2; FGF20; DUSP8A; MAP2K6; IKBKG; PRKACBA; HSPB1; PAK1; CACNA1BA; NFATC1
Cardiac muscle contraction
CACNG4; UQCRC1; COX7B2; ATP1B4; COX5B2; CACNB2; CACNG1; COX7C; CACNG2; CACNA2D1A
Adrenergic signaling in cardiomyocytes
GNAI3; ATP1A1A.1; SLC9A1; CAMK2B; ADCY1A; CALM3; GNAI2A; CREB3L3L; PRKACB; Adcy4
Oxytocin signaling pathway
PRKACG; PLCB4; PIK3R2; ITPR1; MYLK; PIK3R1; PPP3R2; PLA2G4D; RYR3; PPP3R1
Hypertrophic cardiomyopathy (HCM)
PRKAB2; RYR2; ITGB6; TPM2; SLC8A1; LAMA2; ITGA8; TGFB1; TPM3; DES
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGB4; ITGB1; EMD; SGCG; ITGB6; CACNB2; SGCD; ATP2A2; CACNG8; ACTN3
Dilated cardiomyopathy
CACNB4; TPM1; CACNA2D3; CACNG3; IGF1; ITGA4; DMD; GNAS; CACNB2; MYL2

Protein Function

Cacnb4 has several biochemical functions, for example, contributes_to high voltage-gated calcium channel activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cacnb4 itself. We selected most functions Cacnb4 had, and list some proteins which have the same functions with Cacnb4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to high voltage-gated calcium channel activity
Related Protein CACNB2; CACNB4
Function protein binding
Related Protein GRAP; SLC38A2; CRX; ITGAL; MMP14; SYCE1; TXNIP; OSBPL2; DOK1; LIN37
Function protein kinase binding
Related Protein RHEB; STAT3; PTPRC; NBEA; CDK5; CDKN2C; STAP1; CCNT2A; BAG5; CASP9
Function contributes_to voltage-gated calcium channel activity
Related Protein CACNB4; CACNA2D1; CACNB3

Interacting Protein

Cacnb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cacnb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cacnb4.
FASLG; PTN; TBL3; MED31

Cacnb4 Related Articles

Billings, SE; Clarke, GL; et al. ELKS1 and Ca2+ channel subunit beta 4 interact and colocalize at cerebellar synapses. NEUROREPORT 23:49-54(2012).
Fahanik-babaei, J; Eliassi, A; et al. Electro-pharmacological profile of a mitochondrial inner membrane big-potassium channel from rat brain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808:454-460(2011).