DDB1

  • Official Full Name

    damage-specific DNA binding protein 1, 127kDa

  • Overview

    This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

  • Synonyms

    Damage specific DNA binding protein 1;Damage-specific DNA-binding protein 1;DDB 1;DDB p127 subunit;Ddb1;DDB1_HUMAN;DDBa;DNA damage binding protein 1;DNA damage-binding protein 1;DNA damage-binding protein a;HBV X-associated protein 1;UV damaged DNA binding factor;UV-damaged DNA-binding protein 1;UV DDB 1;UV DDB1;UV-damaged DNA-binding factor;X associated protein 1;XAP 1;XAP-1;XAP1;Xeroderma pigmentosum group E complementing protein;Xeroderma pigmentosum group E-complementing protein;XPCE;XPE;XPE BF;XPE binding factor;XPE-binding factor

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • Insect cells
  • Insect Cells
  • In Vitro Cell Free System
  • His
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
DDB1-11877H Recombinant Human DDB1 protein, His-tagged E.coli Human His 1-400 aa
DDB1-10899Z Recombinant Zebrafish DDB1 Mammalian Cells Zebrafish His
DDB1-28308TH Recombinant Human DDB1 protein, GST-tagged Wheat Germ Human GST 1-1140 a.a.
DDB1-4381M Recombinant Mouse DDB1 Protein Mammalian Cells Mouse His
DDB1-5790C Recombinant Chicken DDB1 Mammalian Cells Chicken His
DDB1-2251M Recombinant Mouse DDB1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
DDB1-2251M-B Recombinant Mouse DDB1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DDB1-33HFL Recombinant Full Length Human damage specific DNA binding protein 1 Protein, GST tagged Insect cells Human GST Full L. 1-1140aa
DDB1-3982H Recombinant Human DDB1 Protein Insect Cells Human
DDB1-6896HF Recombinant Full Length Human DDB1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1140 amino acids

    Involved Pathway

    DDB1 involved in several pathways and played different roles in them. We selected most pathways DDB1 participated on our site, such as DNA Damage Bypass,DNA Damage Recognition in GG-NER,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gap-filling DNA repair synthesis and ligation in TC-NER ZFP830,ERCC8,TCEA1,ZNF830,PPIE,KIAA1530
    Dual Incision in GG-NER CHD1L,PARP2,DDB2
    Dual incision in TC-NER KIAA1530,TCEA1,ZNF830,PPIE,ZFP830,ERCC8
    DNA Damage Bypass POLD3,USP43A,DTL,RAD18,ZBTB32,POLI,SPRTN,USP10,MAD2L2,KIAA0101
    Formation of TC-NER Pre-Incision Complex COPS7B,COPS7A,ZFP830,ZNF830,COPS8,COPS6,GPS1,TCEA1,PPIE,COPS5
    DNA Damage Recognition in GG-NER YY1A,COPS2,YY1,COPS3,MCRS1,NFRKB,INO80B,CETN2,ACTL6A,DDB2
    Formation of Incision Complex in GG-NER RNF111,PIAS3,DDB2,USP45,PARP2,CETN2,CHD1L
    DNA Repair USP45,INO80E,ZFP830,UBE2L6,COPS8,COPS4,RHNO1,MGMT,TFPT,FUZ

    Protein Function

    DDB1 has several biochemical functions, for example, DNA binding,contributes_to damaged DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB1 itself. We selected most functions DDB1 had, and list some proteins which have the same functions with DDB1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to damaged DNA binding CUL4B,DDB2,NBN
    DNA binding SERPINA3,HIST1H2AA,ZNF496,LHX1A,ZNF385A,FEZF1,GZF1,HIST1H4E,TBX6,ZFP710
    protein binding CLK4,CISH,TSC22D1,EYA4,CEP152,CXXC1,CAB39,SHISA3,CCDC146,ULK3

    Interacting Protein

    DDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB1.

    CUL4B;DDB2;CUL4A

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