| Official Full Name | damage-specific DNA binding protein 1, 127kDa |
| Background | This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. |
| Synonyms | Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV-damaged DNA-binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; X associated protein 1; XAP 1; XAP-1; XAP1; Xeroderma pigmentosum group E complementing protein; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-binding factor |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
DDB1 involved in several pathways and played different roles in them. We selected most pathways DDB1 participated on our site, such as DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Damage Bypass | KIAA0101; DDB1; ZBTB32; MAD2L2; POLD3; RAD18; DTL; USP10; SPRTN; USP43A |
| DNA Damage Recognition in GG-NER | INO80E; CETN2; YY1; COPS3; ACTR5; GPS1; COPS2; DDB1; NFRKB; INO80C |
| DNA Repair | INO80B; WRN; DDB1; PPP4R2; RAD1; UIMC1; RAD9; KDM4B; EME2; COPS7A |
| Dual Incision in GG-NER | DDB2; DDB1; CHD1L; PARP2 |
| Dual incision in TC-NER | ZNF830; TCEA1; ZFP830; PPIE; ERCC8; DDB1; KIAA1530 |
| Formation of Incision Complex in GG-NER | DDB2; DDB1; PARP2; RNF111; CHD1L; PIAS3; USP45; CETN2 |
| Formation of TC-NER Pre-Incision Complex | DDB1; COPS7B; COPS4; COPS3; COPS7A; ZNF830; COPS6; ZFP830; PPIE; COPS8 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | TCEA1; ZFP830; ZNF830; PPIE; DDB1; ERCC8; KIAA1530 |
DDB1 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB1 itself. We selected most functions DDB1 had, and list some proteins which have the same functions with DDB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HELZ2; RUNX2B; POLR2B; ZNF23; MYSM1; FANCM; ZNF556; ZNF771; SMUG1; THAP11 |
| contributes_to damaged DNA binding | CUL4B; NBN; DDB2; DDB1 |
| protein binding | POLD2; ATG3; DLX2; SNRPF; EPC1; SOST; CCDC130; EMX2; EIF2S2; PIH1D2 |
DDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB1.
CUL4B; DDB2; CUL4A
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