DDB1 Protein, damage-specific DNA binding protein 1, 127kDa

DDB1

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DDB1

Official Full Name damage-specific DNA binding protein 1, 127kDa
Background This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
Synonyms Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV-damaged DNA-binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; X associated protein 1; XAP 1; XAP-1; XAP1; Xeroderma pigmentosum group E complementing protein; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-binding factor
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Insect cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDB1-3982H Recombinant Human DDB1 Protein Insect cell
    Human DDB1-928H Recombinant Human DDB1/CRBN Complex Protein Insect cell
    Human DDB1-11877H Recombinant Human DDB1, His-tagged E.coli His
    Human DDB1-28308TH Recombinant Human DDB1 protein, GST-tagged Wheat Germ GST
    Mouse DDB1-4381M Recombinant Mouse DDB1 Protein Mammalian Cell His
    Chicken DDB1-5790C Recombinant Chicken DDB1 Mammalian Cell His
    Zebrafish DDB1-10899Z Recombinant Zebrafish DDB1 Mammalian Cell His

    DDB1 involved in several pathways and played different roles in them. We selected most pathways DDB1 participated on our site, such as DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Damage Bypass KIAA0101; DDB1; ZBTB32; MAD2L2; POLD3; RAD18; DTL; USP10; SPRTN; USP43A
    DNA Damage Recognition in GG-NER INO80E; CETN2; YY1; COPS3; ACTR5; GPS1; COPS2; DDB1; NFRKB; INO80C
    DNA Repair INO80B; WRN; DDB1; PPP4R2; RAD1; UIMC1; RAD9; KDM4B; EME2; COPS7A
    Dual Incision in GG-NER DDB2; DDB1; CHD1L; PARP2
    Dual incision in TC-NER ZNF830; TCEA1; ZFP830; PPIE; ERCC8; DDB1; KIAA1530
    Formation of Incision Complex in GG-NER DDB2; DDB1; PARP2; RNF111; CHD1L; PIAS3; USP45; CETN2
    Formation of TC-NER Pre-Incision Complex DDB1; COPS7B; COPS4; COPS3; COPS7A; ZNF830; COPS6; ZFP830; PPIE; COPS8
    Gap-filling DNA repair synthesis and ligation in TC-NER TCEA1; ZFP830; ZNF830; PPIE; DDB1; ERCC8; KIAA1530

    DDB1 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB1 itself. We selected most functions DDB1 had, and list some proteins which have the same functions with DDB1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HELZ2; RUNX2B; POLR2B; ZNF23; MYSM1; FANCM; ZNF556; ZNF771; SMUG1; THAP11
    contributes_to damaged DNA binding CUL4B; NBN; DDB2; DDB1
    protein binding POLD2; ATG3; DLX2; SNRPF; EPC1; SOST; CCDC130; EMX2; EIF2S2; PIH1D2

    DDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB1.

    CUL4B; DDB2; CUL4A

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