ddr1
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  • Official Full Name
  • discoidin domain receptor tyrosine kinase 1
  • Background
  • The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. Th
  • Synonyms
  • DDR1; discoidin domain receptor tyrosine kinase 1; CAK, discoidin domain receptor family, member 1 , EDDR1, NEP, NTRK4, PTK3A; epithelial discoidin domain-containing receptor 1; CD167; RTK6; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma ki
Cat.#:DDR1-212HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR1 Protein, MYC/DDK-tagged
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Cat.#:DDR1-219HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human DDR1 Protein, DDK-tagged
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Cat.#:DDR1-220HTag:Fc/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human DDR1 Protein, hIgG-His-tagged
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Cat.#:DDR1-2453HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDR1 Protein
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Cat.#:DDR1-2454HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDR1 Protein, GST-tagged
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Cat.#:Ddr1-391MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Discoidin Domain Receptor Family, Member 1
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Cat.#:DDR1-29455THTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human DDR1 protein, GST-tagged
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Cat.#:DDR1-509HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DDR1, GST-tagged
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Cat.#:DDR1-5688HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDR1 protein, His-tagged
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Cat.#:DDR1-620HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR1, His tagged
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Cat.#:DDR1-7297HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDR1, His & GST tagged
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Cat.#:DDR1-814HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human DDR1 Protein, DDK-tagged
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Cat.#:DDR1-815HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human DDR1 Protein, DDK/His-tagged
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Cat.#:DDR1-816HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human DDR1 Protein, DDK-tagged
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Cat.#:Ddr1-6919MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ddr1, Fc tagged
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Cat.#:Ddr1-7402MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ddr1, His & GST tagged
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Cat.#:Ddr1-53RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ddr1, Fc tagged
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Cat.#:Ddr1-8808RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ddr1, His tagged
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Cat.#:DDR1-1209RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDR1 Protein, His-tagged
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Cat.#:DDR1-1593RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey DDR1 Protein
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Cat.#:DDR1-1594RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey DDR1 Protein, hIgG1-tagged
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Cat.#:DDR1-1595RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey DDR1 Protein, hIgG4-tagged
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Cat.#:Ddr1-1150MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ddr1, His-tagged
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Cat.#:DDR1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDR1 cell lysate
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Cat.#:DDR1-2534HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR1 cell lysate
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Cat.#:DDR1-1709MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse DDR1 cell lysate
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Cat.#:DDR1-401MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse DDR1 cell lysate
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Cat.#:DDR1-1081RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat DDR1 cell lysate
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Cat.#:Kit-1560Tag:
Source (Host):Species:
Product nameU2OS DDR1 Bioassay Kit
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Cat.#:Kit-1579Tag:
Source (Host):Species:
Product nameDDR1 Functional Assay Kit
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Involved Pathway

DDR1 involved in several pathways and played different roles in them. We selected most pathways DDR1 participated on our site, such as Extracellular matrix organization, Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Extracellular matrix organization
ADAMTS8; MFAP1; MGC174152; COL25A1; PCOLCE2B; JAM2B; COL2A1; LTBP3; MMP19; LOXL4
Non-integrin membrane-ECM interactions
LAMC3; TTR; DMD; DDR2; DDR1; TRAPPC4

Protein Function

DDR1 has several biochemical functions, for example, ATP binding, collagen binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDR1 itself. We selected most functions DDR1 had, and list some proteins which have the same functions with DDR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ADK; MYH3; TP53RK; MAGI3; CDKL4; YTHDC2; TK2; EHD2; CHKA; CLK4
Function collagen binding
Related Protein SERPINH1B; PDGFA; ITGA2; C1QTNF1; ABI3BP; LACRT; RELL2; PAK1; ASPN; GPR56
Function metal ion binding
Related Protein ZBTB8B; BTK; RARAB; ZBTB20; ZFP593; KIN; ZNF705B; NR5A1B; UNC13C; TGM5
Function protein binding
Related Protein CCDC120; ZCCHC17; RABGAP1L; CUBN; MRPS12; DYNLT1; KLF15; HTN1; TMEM149; DYNC1I2
Function protein tyrosine kinase collagen receptor activity
Related Protein DDR1; DDR2
Function transmembrane receptor protein tyrosine kinase activity
Related Protein IGF1RB; KDRL; NTRK3A; DDR1; KITA; TRIM27; RET; INSRB; EPHA4B; ERBB2

Interacting Protein

DDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDR1.
NCK2; PTPN11; RGS2; bosutinib; imatinib; dasatinib; SNAPIN; NUDT3; TTR; TM4SF1; MAPK6; BEND5

DDR1 Related Articles

Favreau, AJ; Vary, CPH; et al. Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia. CANCER MEDICINE 3:265-272(2014).
Carafoli, F; Hohenester, E; et al. Collagen recognition and transmembrane signalling by discoidin domain receptors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1834:2187-2194(2013).