Recombinant Full Length Human DDR1 Protein, C-Flag-tagged

• Cat.No.: DDR1-1331HFL
• Product Overview: Recombinant Full Length Human DDR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 100.9 kDa
• AA Sequence: MGPEALSSLLLLLLVASGDADMKGH FDPAKCRYALGMQDRTIPDSDISAS SSWSDSTAARHSRLESSDGD GAWCPAGSVFPKEEEYLQVDLQRLH LVALVGTQGRHAGGLGKEFSRSYRL RYSRDGRRWMGWKDRWGQEV ISGNEDPEGVVLKDLGPPMVARLVR FYPRADRVMSVCLRVELYGCLWRDG LLSYTAPVGQTMYLSEAVYL NDSTYDGHTVGGLQYGGLGQLADGV VGLDDFRKSQELRVWPGYDYVGWSN HSFSSGYVEMEFEFDRLRAF QAMQVHCNNMHTLGARLPGGVECRF RRGPAMAWEGEPMRHNLGGNLGDPR ARAVSVPLGGRVARFLQCRF LFAGPWLLFSEISFISDVVNNSSPA LGGTFPPAPWWPPGPPPTNFSSLEL EPRGQQPVAKAEGSPTAILI GCLVAIILLLLLIIALMLWRLHWRR LLSKAERRVLEEELTVHLSVPGDTI LINNRPGPREPPPYQEPRPR GNPPHSAPCVPNGSALLLSNPAYRL LLATYARPPRGPGPPTPAWAKPTNT QAYSGDYMEPEKPGAPLLPP PPQNSVPHYAEADIVTLQGVTGGNT YAVPALPPGAVGDGPPRVDFPRSRL RFKEKLGEGQFGEVHLCEVD SPQDLVSLDFPLNVRKGHPLLVAVK ILRPDATKNARNDFLKEVKIMSRLK DPNIIRLLGVCVQDDPLCMI TDYMENGDLNQFLSAHQLEDKAAEG APGDGQAAQGPTISYPMLLHVAAQI ASGMRYLATLNFVHRDLATR NCLVGENFTIKIADFGMSRNLYAGD YYRVQGRAVLPIRWMAWECILMGKF TTASDVWAFGVTLWEVLMLC RAQPFGQLTDEQVIENAGEFFRDQG RQVYLSRPPACPQGLYELMLRCWSR ESEQRPPFSQLHRFLAEDAL
  NTVTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane

Gene Information

• Gene Name: DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: DDR1
• Synonyms: CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
• Gene ID: 780
• mRNA Refseq: NM_001954.5
• Protein Refseq: NP_001945.3
• MIM: 600408
• UniProt ID: Q08345