Recombinant Human DDR1 Protein

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Recombinant Human DDR1 Protein

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Cat.No. : DDR1-2453H
Product Overview : Human DDR1 full-length ORF (NP_001945.3) recombinant protein without tag.
Description : Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Source : Wheat Germ
Species : Human
Form : Liquid
Molecular Mass : 97.2 kDa
AA Sequence : MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE PPPYQEPRPR GNPPHSAPCV PNGSAYSGDY MEPEKPGAPL LPPPPQNSVP HYAEADIVTL QGVTGGNTYA VPALPPGAVG DGPPRVDFPR SRLRFKEKLG EGQFGEVHLC EVDSPQDLVS LDFPLNVRKG HPLLVAVKIL RPDATKNARN DFLKEVKIMS RLKDPNIIRL LGVCVQDDPL CMITDYMENG DLNQFLSAHQ LEDKAAEGAP GDGQAAQGPT ISYPMLLHVA AQIASGMRYL ATLNFVHRDL ATRNCLVGEN FTIKIADFGM SRNLYAGDYY RVQGRAVLPI RWMAWECILM GKFTTASDVW AFGVTLWEVL MLCRAQPFGQ LTDEQVIENA GEFFRDQGRQ VYLSRPPACP QGLYELMLRC WSRESEQRPP FSQLHRFLAE DALNTV
Applications : Antibody Production
Functional Study
Compound Screening
Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Gene Name : DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens ]
Official Symbol : DDR1
Synonyms : DDR1; discoidin domain receptor tyrosine kinase 1; CAK, discoidin domain receptor family, member 1 , EDDR1, NEP, NTRK4, PTK3A; epithelial discoidin domain-containing receptor 1; CD167; RTK6; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma kinase 10; tyrosine-protein kinase CAK; protein-tyrosine kinase RTK-6; neuroepithelial tyrosine kinase; PTK3A protein tyrosine kinase 3A; CD167 antigen-like family member A; neurotrophic tyrosine kinase, receptor, type 4; CAK; DDR; NEP; HGK2; PTK3; TRKE; EDDR1; MCK10; NTRK4; PTK3A;
Gene ID : 780
mRNA Refseq : NM_001202521
Protein Refseq : NP_001189450
MIM : 600408
UniProt ID : Q08345

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