dmc1
Share
  • Official Full Name
  • DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
  • Background
  • The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.
  • Synonyms
  • DMC1; DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast); DMC1 (dosage suppressor of mck1, yeast homolog) meiosis specific homologous recombination; meiotic recombination protein DMC1/LIM15 homolog; LIM15; disrupted meiotic cDNA 1 homolog; dJ199H16.1; DMC 1; DMC1 dosage suppressor of mck1 homolog; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast); DMC1 homologue; DMC1H; HsLim15; MGC150472; MGC150473; disrupted meiotic cDNA1, yeast, homolog of
Cat.#:DMC1-2703HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DMC1 Protein, GST-tagged
+Inquiry
Cat.#:DMC1-12035HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DMC1, GST-tagged
+Inquiry
Cat.#:DMC1-2919ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DMC1
+Inquiry
Cat.#:DMC1-6900HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DMC1 293 Cell Lysate
+Inquiry

Involved Pathway

DMC1 involved in several pathways and played different roles in them. We selected most pathways DMC1 participated on our site, such as Cell Cycle, Meiosis, Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
OFD1; MYBL2; TUBG1; LEMD3; ORC2L; NUF2; TGFB1A; CTDNEP1B; CUL1A; NCAPD2
Meiosis
SPO11; TERF2; MND1; DIDO1; PSMC3IP; MSH5; DMC1; SYNE1; TEX12; MSH4
Meiotic recombination
MSH5; MND1; TEX15; PSMC3IP; MSH4; SPO11; DMC1
Ovarian Infertility Genes
INHA; NR5A1; ZP2; DMC1; DAZL; NRIP1; SYNE2; ZP3; GJA4; MSH5

Protein Function

DMC1 has several biochemical functions, for example, ATP binding, DNA binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DMC1 itself. We selected most functions DMC1 had, and list some proteins which have the same functions with DMC1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein P2RY1; ACVR1; KCNJ10; PRKCBA; PFKFB2A; PRKY; PRKCI; SPO11; ABCB1; FLT3
Function DNA binding
Related Protein DDIT3; POLR3K; HESX1; CDX1B; PNX; NKX3.2; BRPF1; ZSCAN18; ONECUTL; STRBP
Function DNA-dependent ATPase activity
Related Protein DHX36; SMARCA2; MSH5; SMARCAL1; RAD51C; SMARCA4; RAD51B; TOP2A; TTF2; CHD8
Function double-stranded DNA binding
Related Protein TDP1; PIN4; LSM14A; MCM10; RAD51L3; RAD51B; SATB1; CSDA; GTF2H4; TRP53
Function contributes_to endodeoxyribonuclease activity
Related Protein RAD51L1; ERCC4; RAD51B; RAD51; DMC1; RAD51D; XRCC2; RAD51L3
Function four-way junction DNA binding
Related Protein YY1; RAD51L3; RAD51; HMGB3; HMGB2; MEN1; RAD51L1; HMGB1; DMC1
Function protein binding
Related Protein GTF2E1; APP; NFATC3; FBXO45; EIF3I; BEX2; COMMD9; UBE2O; C19orf46; MRPL51
Function recombinase activity
Related Protein XRCC2; RAD51C; RAD51L1; RAD51D; XRCC3; DMC1; RAD51B; RBPJ; RAD51; RAD51L3
Function single-stranded DNA binding
Related Protein BRCA2; SSBP2; LUZP4; NABP1A; RPA2; TDP2; NCL; RAD51B; RAD51L1; TDP1

Interacting Protein

DMC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMC1.
BRCA2; 79734; SDCBP; PSMA3

DMC1 Related Articles

Dyce, PW; Shen, W; et al. Analysis of Oocyte-Like Cells Differentiated from Porcine Fetal Skin-Derived Stem Cells. STEM CELLS AND DEVELOPMENT 20:809-819(2011).
Johnson, R; Borde, V; et al. Excess single-stranded DNA inhibits meiotic double-strand break repair. PLOS GENETICS 3:2338-2349(2007).