DNA2
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Official Full Name
DNA replication helicase/nuclease 2 -
Overview
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010] -
Synonyms
DNA2;DNA replication helicase/nuclease 2;DNA2L;PEOA6;hDNA2;DNA replication ATP-dependent helicase/nuclease DNA2;DNA2-like helicase;DNA replication helicase 2 homolog;DNA replication ATP-dependent helicase-like homolog
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- DDK
- Myc
- Avi
- Fc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DNA2-12048H | Recombinant Human DNA2 protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| DNA2-1636C | Recombinant Chicken DNA2 | Mammalian Cells | Chicken | His |
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| DNA2-197HCL | Recombinant Human DNA2 HEK293T cell lysate | HEK293 | Human | DDK&Myc |
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| DNA2-4664M | Recombinant Mouse DNA2 Protein | Mammalian Cells | Mouse | His |
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| DNA2-2425M | Recombinant Mouse DNA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| DNA2-2425M-B | Recombinant Mouse DNA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DNA2-3789HFL | Recombinant Full Length Human DNA2, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
DNA2 involved in several pathways and played different roles in them. We selected most pathways DNA2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | THRSP,USP45,INO80C,HUS1,INO80B,RAD51AP1,ACTL6A,NFRKB,TFPT,USP10 |
| Cell Cycle, Mitotic | GINS3,TUBGCP4,AHCTF1,B9D2,ARPP19,LIN54,BLZF1,ENSAA,SKA2,CENPP |
| DNA strand elongation | GINS4,GINS2,GINS1,GINS3 |
| DNA Replication | POLE,PRIM1,RPA4,POLE3,RNASEH1,MCM10,LIG1,POLD1,POLA2,MCM6L |
| DNA Double-Strand Break Repair | FAM175A,TDP2,HUS1,SMARCA5,TIPIN,UBE2V2,TP53BP1,PARP2,RAD9A,TDP1 |
| Cell cycle | CEP78,BUB1B,CENPW,MDM2,TFDP1A,FKBP6,NCAPH,MCM6,NUP50,SMC1AL |
| Chromosome Maintenance | POT1,HJURP,MIS18BP1,CENPI,TERF2,CENPW,ACD,MLF1IP,CENPK,CENPN |
Protein Function
DNA2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,5-3 DNA helicase activity,5-flap endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNA2 itself. We selected most functions DNA2 had, and list some proteins which have the same functions with DNA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| site-specific endodeoxyribonuclease activity, specific for altered base | APEX1 |
| single-stranded DNA-dependent ATPase activity | RAD18,RAD51 |
| 4 iron, 4 sulfur cluster binding | ISCUB,NDUFV1,ACO2,MOCS1,IREB2,EXO5,DEM1,NUBP1,NDUFS7,CDKAL1 |
| ATP binding | CARKD,GRK1A,HSPA5,GLULA,PLK1,TBK1,PSKH2,GC3,TRIT1,PSMC2 |
| ATPase activity | IDE,ABCD3B,ABCC12,VPS4B,ABCA9,MLH1,EIF4A1B,RNF213,ABCG2A,PICK1 |
| NOT DNA helicase activity | ERCC8,ERCC6 |
| protein binding | ZWINT,TMCO6,C10orf137,RAB35,ZC3HAV1,MAGI1,PPP3CC,KCTD14,CLU,GTF2IRD2 |
| DNA binding | UNCX,TAF9,FANCM,HOXC4A,ZFP689,NFYB,ZNF571,PRDM12,MLLT1,POU5F1 |
| metal ion binding | WDFY3,GNA12,MMP13A,GALNTL2,STK24,TRIM35-23,TIMP1,ITGA10,ZNF131,ARSD |
Interacting Protein
DNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNA2.
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