DNA2

  • Official Full Name

    DNA replication helicase/nuclease 2
  • Overview

    DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
  • Synonyms

    DNA2;DNA replication helicase/nuclease 2;DNA2L;PEOA6;hDNA2;DNA replication ATP-dependent helicase/nuclease DNA2;DNA2-like helicase;DNA replication helicase 2 homolog;DNA replication ATP-dependent helicase-like homolog

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
DNA2-12048H Recombinant Human DNA2 protein, His-tagged E.coli Human His 1-350 aa
DNA2-1636C Recombinant Chicken DNA2 Mammalian Cells Chicken His
DNA2-197HCL Recombinant Human DNA2 HEK293T cell lysate HEK293 Human DDK&Myc
DNA2-4664M Recombinant Mouse DNA2 Protein Mammalian Cells Mouse His
DNA2-2425M Recombinant Mouse DNA2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
DNA2-2425M-B Recombinant Mouse DNA2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DNA2-3789HFL Recombinant Full Length Human DNA2, Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    DNA2 involved in several pathways and played different roles in them. We selected most pathways DNA2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle, Mitotic CEP78,PHF8,USO1,CKS1B,ENSA,CDK11B,HIST3H2BB,AHCTF1,STAG1,TUBGCP3
    DNA Double-Strand Break Repair TIMELESS,TDP2,EYA3,CLSPN,TOPBP1,RAD51AP1,SMARCA5,EYA4,RAD17,EME1
    DNA Replication POLE,RFC1,RFC2,MCM10,GINS3,RNASEH2A,POLD1,RPA3,POLD2,rnhA
    Cell cycle ORC1L,CCP110,DCTN2,CCNB3,TBC1D8,WEE2,NSL1,CEP57,GADD45A,RNF168
    DNA Repair KDM4A,INO80C,PPP4R2B,PIAS3,GEN1,ASCC3,TCEA1,NFRKB,INO80B,INO80
    Chromosome Maintenance CENPH,ACD,MIS18BP1,PANE1,TINF2,TERF2,MIS18A,DKC1,MLF1IP,WRAP53
    DNA strand elongation GINS4,GINS3,GINS1,GINS2

    Protein Function

    DNA2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,5-3 DNA helicase activity,5-flap endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNA2 itself. We selected most functions DNA2 had, and list some proteins which have the same functions with DNA2. You can find most of the proteins on our site.

    Function Related Protein
    5-flap endonuclease activity FEN1,SLX1B,FAN1
    NOT DNA helicase activity ERCC8,ERCC6
    protein binding POLG,C10orf46,ELF3,VAC14,PAK1,EPOR,IFT27,PLDN,SOX7,MSTN
    site-specific endodeoxyribonuclease activity, specific for altered base APEX1
    DNA helicase activity PIF1,MCM6L,FBXO18,WRN,MCM3L,RAD54B,SUPV3L1,RECQL5,IGHMBP2,PEO1
    ATPase activity EIF4A1B,DYNC1H1,CENPE,NSFA,ABCE1,ATF7IP,KIF7,KIF20A,ABCG2D,KIFC2
    metal ion binding EGLN1B,ZNF643,FBP2,SCRT1,TATDN1,ANKMY2,HGD,S100A10A,GTSF1L,NME3
    helicase activity PEO1,FANCM,MOV10B.1,DHX58,ANXA1,SMARCAD1,WRN,HELZ2,GTF2F2B,TDRD9
    4 iron, 4 sulfur cluster binding ISCUB,BRIP1,ACO2,ISCA1,NDUFS7,EXO5,PRIM2,PPAT,REV3L,MOCS1

    Interacting Protein

    DNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNA2.

    d-mannose

    Resources

    References

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