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DNA2

  • Official Full Name

    DNA replication helicase/nuclease 2

  • Overview

    DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
  • Synonyms

    DNA2; DNA replication helicase/nuclease 2; DNA2L; PEOA6; hDNA2; DNA replication ATP-dependent helicase/nuclease DNA2; DNA2-like helicase; DNA replication helicase 2 homolog; DNA replication ATP-dependent helicase-like homolog;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNA2-12048H Recombinant Human DNA2 protein, His-tagged E.coli His 1-350 aa
Human DNA2-197HCL Recombinant Human DNA2 HEK293T cell lysate HEK293T Myc/DDK
Human DNA2-3789HFL Recombinant Full Length Human DNA2, Flag-tagged Mamanlian cells Flag
Mouse DNA2-4664M Recombinant Mouse DNA2 Protein Mammalian Cell His
Mouse DNA2-2425M Recombinant Mouse DNA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DNA2-2425M-B Recombinant Mouse DNA2 Protein Pre-coupled Magnetic Beads HEK293
Chicken DNA2-1636C Recombinant Chicken DNA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DNA2 involved in several pathways and played different roles in them. We selected most pathways DNA2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleNDEL1A;MAD2L1;DMC1;CENPC1;CTDNEP1B;CEP76;SMARCA5;SKP2;BLZF1
Cell Cycle, MitoticMYBL2;SPDL1;LIN54;CDK11A;ZW10;LEMD3;CKAP5;OFD1;CTDNEP1B
Chromosome MaintenanceAPITD1;CENPL;MIS18A;HJURP;ACD;RBBP4;RBBP7;CENPH;CENPC1
DNA Double-Strand Break RepairFUZ;EME1;BRE;RHNO1;PARP1;RAD51AP1;RAD17;PPP4CA;CLSPN
DNA RepairRAD9B;DDB1;ZNF830;BABAM1;UBE2V2;COPS6;TFPT;MGMT;TOPBP1
DNA ReplicationPOLA2;RPA2;PCNA;POLD1;SSBP1;MCM2;RNASEH2B;DNA2;rnhA
DNA strand elongationGINS4;GINS1;GINS3;GINS2;DNA2

DNA2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, 5-flap endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNA2 itself. We selected most functions DNA2 had, and list some proteins which have the same functions with DNA2. You can find most of the proteins on our site.

Function Related Protein
4 iron, 4 sulfur cluster bindingDPYDB;REV3L;RSAD1;NUBP2;ERCC2;NDUFS8A;NDUFS8;PPAT;ISCA2
5-3 DNA helicase activityPEO1;ERCC2;DNA2;C10orf2
5-flap endonuclease activityDNA2;FEN1;SLX1B;FAN1
ATP bindingCSNK1DA;KIF2A;MAPK12;ADCK2;MAP2K4B;MUSK;SWAP70;RAD50;PRKCH
ATPase activitySMARCA4A;ABCF3;PSMC4;MYO19;HSPA1A;HSPA1B;NSFA;ABCC1;TOR1B
DNA bindingZFP2;ZFP423;CREB1B;LASS4;ZNF10;TADA2B;CIC;NKX2.2B;HYPM
DNA helicase activityMCM3;MCM2;SUPV3L1;PEO1;PIF1;RECQL;WRN;DNA2;RUVBL1
NOT DNA helicase activityERCC8;DNA2;ERCC6
helicase activitySNRNP200;DHX32A;GTF2F2;DNA2;DDX39AA;SETX;HELZ2;EIF4A1;ERCC6L
metal ion bindingZNF671;MOXD1L;DAGLB;BTR18;FRRS1;TRIM35-21;HE1A;ZBTB7B;FIBCD1
nuclease activityREXO1;DROSHA;DOM3Z;DNA2;USB1;RNASEL4;ANG3;RNASEL2;DNASE1L3L
protein bindingFCN3;C1orf216;CSK;DNAJC7;NMNAT1;EXOC8;EEF1G;CCDC117;ITGA7
single-stranded DNA-dependent ATPase activityRAD18;DNA2;RAD51
site-specific endodeoxyribonuclease activity, specific for altered baseAPEX1;DNA2

DNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNA2.

d-mannose

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