DOHH Protein, deoxyhypusine hydroxylase/monooxygenase


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Official Full Name deoxyhypusine hydroxylase/monooxygenase
Background This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.
Synonyms DOHH; deoxyhypusine hydroxylase/monooxygenase; HEAT like (PBS lyase) repeat containing 1 , HLRC1; deoxyhypusine hydroxylase; MGC4293; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase; hDOHH; HEAT like PBS lyase repeat containing; HEAT like repeat containing protein 1; HEAT-like repeat-containing protein 1; HEAT-like (PBS lyase) repeat containing 1; HLRC1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Dohh-201M Recombinant Mouse Dohh Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human DOHH-12125H Recombinant Human DOHH, His-tagged E.coli His
    Human DOHH-2480H Recombinant Human DOHH Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DOHH-2809H Recombinant Human DOHH Protein, GST-tagged Wheat Germ GST
    Human DOHH-505HCL Recombinant Human DOHH cell lysate N/A
    Mouse DOHH-4760M Recombinant Mouse DOHH Protein Mammalian Cell His
    Rat DOHH-1930R Recombinant Rat DOHH Protein Mammalian Cell His
    Rhesus Macaque DOHH-1310R Recombinant Rhesus monkey DOHH Protein, His-tagged Mammalian Cell His
    Chicken DOHH-3064C Recombinant Chicken DOHH Mammalian Cell His
    Zebrafish DOHH-9966Z Recombinant Zebrafish DOHH Mammalian Cell His

    DOHH involved in several pathways and played different roles in them. We selected most pathways DOHH participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOHH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gamma carboxylation, hypusine formation and arylsulfatase activation EIF5A; PROZ; ARSE; GAS6; ARSH; F9A; DPH2; PROCA; ATPBD4; DOHH
    Hypusine synthesis from eIF5A-lysine DOHH; EIF5A; DHPS; EIF5A2
    Metabolism of proteins FBXW2; ATP6AP2; KLK13; MBOAT4; DMBT1; GRPEL1; PROZ; EIF2B1; EIF4H; CGB7
    Post-translational protein modification PHC1; ALG14; LMAN2; TFG; ARSI; DPH3; EIF5A; EID3; PREB; SLC35A1
    hypusine biosynthesis DOHH; DHPS

    DOHH has several biochemical functions, for example, deoxyhypusine monooxygenase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOHH itself. We selected most functions DOHH had, and list some proteins which have the same functions with DOHH. You can find most of the proteins on our site.

    Function Related Protein
    deoxyhypusine monooxygenase activity DOHH
    metal ion binding HBBE3; PPM1E; PDE9A; MCM2; ZIC1; GALNT4; MAT2AL; PLA2G12B; MAZ; NR4A2A
    protein binding KIAA1109; FAM101A; TRIP6; PPP4R4; HDHD2; KCNA3; PHIP; TXNDC12; YIF1A; CLNK

    DOHH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOHH here. Most of them are supplied by our site. Hope this information will be useful for your research of DOHH.


    Zappasodi, R; Bongarzone, I; et al. Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target. BLOOD 118:4421-4430(2011).
    Sgier, D; Zuberbuehler, K; et al. Isolation and characterization of an inhibitory human monoclonal antibody specific to the urokinase-type plasminogen activator, uPA. PROTEIN ENGINEERING DESIGN & SELECTION 23:261-269(2010).

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