dok5
Share
  • Official Full Name
  • docking protein 5
  • Background
  • The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.
  • Synonyms
  • DOK5; docking protein 5; C20orf180, chromosome 20 open reading frame 180; dJ805C22.1; IRS6; IRS-6; insulin receptor substrate 6; downstream of tyrosine kinase 5; C20orf180; MGC16926
Cat.#:DOK5-460HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOK5 Protein (1-198 aa), His-SUMO-tagged
+Inquiry
Cat.#:DOK5-2813HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DOK5 Protein, GST-tagged
+Inquiry
Cat.#:DOK5-4764MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DOK5 Protein
+Inquiry
Cat.#:DOK5-1312RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DOK5 Protein, His-tagged
+Inquiry
Cat.#:DOK5-6845HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DOK5 293 Cell Lysate
+Inquiry

Involved Pathway

DOK5 involved in several pathways and played different roles in them. We selected most pathways DOK5 participated on our site, such as BDNF signaling pathway, Signaling events regulated by Ret tyrosine kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
CDH2; EGR1; FRS3; EIF4E; MAP3K2; EEF2; EGR2; SIRPA; DOK5; CSNK2A1P
Signaling events regulated by Ret tyrosine kinase
DOK5; GFRA1; GDNF; DOK4; PDLIM7; DOK6

Protein Function

DOK5 has several biochemical functions, for example, insulin receptor binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK5 itself. We selected most functions DOK5 had, and list some proteins which have the same functions with DOK5. You can find most of the proteins on our site.
Function
Related Protein
Function insulin receptor binding
Related Protein IRS1; INS1; PTPN11; FRS3; DOK1B; PDPK1; PHIP; INS; LMBRD1; IRS2
Function receptor signaling protein activity
Related Protein Siglece; DCLK1; FLRT2; DOK4; IL4R; CD19; RGS14A; RGS12; IL1RL1; KLK1B3

Interacting Protein

DOK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK5.
EGFR; BNIP3L; OPRM1; CCDC85B

DOK5 Related Articles

Pillai, K; Pourgholami, MH; et al. MUC1 as a Potential Target in Anticancer Therapies. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 38:108-118(2015).
Su, CTT; Nguyen, TD; et al. IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking. BMC BIOINFORMATICS 15:-(2014).