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DOK5

Official Full Name

docking protein 5
Overview

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.
Synonyms

DOK5; docking protein 5; C20orf180, chromosome 20 open reading frame 180; dJ805C22.1; IRS6; IRS-6; insulin receptor substrate 6; downstream of tyrosine kinase 5; C20orf180; MGC16926;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DOK5-2813H	Recombinant Human DOK5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DOK5-6845HCL	Recombinant Human DOK5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DOK5-460H	Recombinant Human DOK5 Protein (1-198 aa), His-SUMO-tagged	E.coli	His/SUMO	1-198 aa	Inquiry
Human	DOK5-3943HF	Recombinant Full Length Human DOK5 Protein, GST-tagged	In Vitro Cell Free System	GST	306 amino acids	Inquiry
Mouse	DOK5-4764M	Recombinant Mouse DOK5 Protein	Mammalian Cell	His		Inquiry
Mouse	DOK5-2485M-B	Recombinant Mouse DOK5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	DOK5-2485M	Recombinant Mouse DOK5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	DOK5-1312R	Recombinant Rhesus monkey DOK5 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DOK5-1137R	Recombinant Rhesus Macaque DOK5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	DOK5-1137R-B	Recombinant Rhesus Macaque DOK5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
DOK5 Related Articles

DOK5 involved in several pathways and played different roles in them. We selected most pathways DOK5 participated on our site, such as BDNF signaling pathway, Signaling events regulated by Ret tyrosine kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
BDNF signaling pathway	CSNK2A1P;CNR1;EIF4E;SIRPA;IGF2BP1;CDKL5;JAK2;SYN1;EGR1
Signaling events regulated by Ret tyrosine kinase	GDNF;GFRA1;DOK4;DOK5;PDLIM7;DOK6

DOK5 has several biochemical functions, for example, insulin receptor binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK5 itself. We selected most functions DOK5 had, and list some proteins which have the same functions with DOK5. You can find most of the proteins on our site.

Function	Related Protein
insulin receptor binding	PHIP;SNX4;GRB10;FRS2;DOK1;PDPK1;SHC1;FRS3;DOK3
receptor signaling protein activity	RGS12B;FCAR;FLRT1;PDCL;DOK1;PLCG1;IL1RL1;ADRB1;FLRT3

DOK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK5.

EGFR; BNIP3L; OPRM1; CCDC85B

Pillai, K; Pourgholami, MH; et al. MUC1 as a Potential Target in Anticancer Therapies. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 38:108-118(2015).

Su, CTT; Nguyen, TD; et al. IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking. BMC BIOINFORMATICS 15:-(2014).