dph1
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  • Official Full Name
  • DPH1 DPH1 homolog (S. cerevisiae)
  • Background
  • Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM;130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation;and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in;synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).
  • Synonyms
  • DPH1; DPH1 homolog (S. cerevisiae); diptheria toxin resistance protein required for diphthamide biosynthesis like 1 (S. cerevisiae) , DPH like 1 (S. cerevisiae) , DPH2L, DPH2L1; diphthamide biosynthesis protein 1; ovarian tumor suppressor candidate 1; OVCA1; DPH-like 1; DPH2-like 1; ovarian cancer-associated gene 1 protein; candidate tumor suppressor in ovarian cancer 1; diphthamide biosynthesis protein 2 homolog-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; DPH2L; DPH2L1; FLJ33211
Cat.#:DPH1-2481HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPH1 Protein, MYC/DDK-tagged
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Cat.#:DPH1-2829HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPH1 Protein, GST-tagged
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Cat.#:DPH1-4785MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPH1 Protein
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Cat.#:DPH1-2418CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DPH1
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Cat.#:DPH1-2584ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DPH1
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Involved Pathway

DPH1 involved in several pathways and played different roles in them. We selected most pathways DPH1 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPH1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activation
GAS6; ARSH; SUMF2; DPH5; EEF2; DPH2; DNAJC24; DHPS; FURINB; FURINA
Metabolism of proteins
NAPG; FKBP9; OTOP2; CBX8; NAT8; TRAPPC2L; PHC1; B3GNT8; DNAJC19; SEC22A
Post-translational protein modification
ARSJ; ADAMTS5; EIF5A2; SMC5; NAPG; GNE; ST6GAL2B; RING1; ST6GALNAC2; SSPO
Synthesis of diphthamide-EEF2
ATPBD4; WDR85; DPH2; DNAJC24; DPH1; OTOP2; DPH5; DPH3

Protein Function

DPH1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPH1 itself. We selected most functions DPH1 had, and list some proteins which have the same functions with DPH1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein QRICH1; ZNF599; NTN4; PARP2; HSD3B7; DUSP19; LAMA1; RAB18; PAAF1; MFAP4

Interacting Protein

DPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPH1.
Dph2

DPH1 Related Articles

Kolaj-Robin, O; McEwen, AG; et al. Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongatordependent tRNA modification. FEBS JOURNAL 282:819-833(2015).
Davydova, E; Ho, AYY; et al. Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2). JOURNAL OF BIOLOGICAL CHEMISTRY 289:30499-30510(2014).