DUSP10 Protein, dual specificity phosphatase 10


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Official Full Name dual specificity phosphatase 10
Background Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the;phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily;(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of;this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue;distribution and subcellular localization, and different modes of inducibility of their expression by extracellular;stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization;is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various;tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different;isoforms have been found for this gene.
Synonyms DUSP10; dual specificity phosphatase 10; dual specificity protein phosphatase 10; MKP 5; MKP5; map kinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 5; MKP
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP10-12203H Recombinant Human DUSP10, GST-tagged E.coli GST
    Human DUSP10-1392H Recombinant Human Dual Specificity Phosphatase 10, His-tagged E.coli His
    Human DUSP10-2922H Recombinant Human DUSP10 Protein, GST-tagged Wheat Germ GST
    Human DUSP10-6784HCL Recombinant Human DUSP10 293 Cell Lysate HEK293 N/A
    Mouse DUSP10-4875M Recombinant Mouse DUSP10 Protein Mammalian Cell His
    Rhesus Macaque DUSP10-1348R Recombinant Rhesus monkey DUSP10 Protein, His-tagged Mammalian Cell His
    Chicken DUSP10-2724C Recombinant Chicken DUSP10 Mammalian Cell His

    DUSP10 involved in several pathways and played different roles in them. We selected most pathways DUSP10 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation MARK3; AKAP9; DUSP1; SPNA2; PSMD5; NRG4; IL17RD; SPRED3; LAMTOR2; PSMA8
    ATF-2 transcription factor network POU2F1; JUNB; DUSP1; JUN; KAT5; DUSP5; HRK; GADD45A; KCNA3; CREB1
    Axon guidance EFNB2A; CLTB; L1CAM; NRG2A; EGF; SEMA3A; AKAP9; COL6A1; SCN3A; COL4A4
    Cytokine Signaling in Immune system IRF9; TRIM3; DUSP4; SPTBN1; EIF4G2; SPTA1; IFIT8; PEBP1; UBE2L6; CISH
    DAP12 interactions PEA15; MARK3; FRS2A; CSF2RB; PAQR3A; NRG3; PEA15A; SIRPB1; SPTB; PTPRA
    DAP12 signaling FGF8B; SPRED3; FGF20A; AGO3; DUSP10; SPRED2; RASGRP4; PEA15; FRS2B; JAK3
    Developmental Biology KALRN; DUSP6; LGI2; SIAH2; CAP2; GDF1; DUSP1; LGI1; ARPC1A; RGMA
    Downstream signal transduction JAK1; FRS2B; AGO2; WDR83; MARK3; CRKL; FGFR1B; SPTBN1; DUSP10; TRAT1

    DUSP10 has several biochemical functions, for example, MAP kinase phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP10 itself. We selected most functions DUSP10 had, and list some proteins which have the same functions with DUSP10. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase phosphatase activity DUSP3B; DUSP3; DUSP10
    MAP kinase tyrosine/serine/threonine phosphatase activity CTDSPL2B; DUSP7; DUSP16; DUSP14; DUSP9; SACM1LA; DUSP18; DUSP10; DUSP2; DUSP1
    phosphoprotein phosphatase activity PPM1LA; PPP1CC; PPM1E; PTPRDB; PPM1AB; PTPRZ1; PPP1R3B; DUSP26; CTDSPL2B; PPP1CAA
    protein tyrosine phosphatase activity DUSP7; CDKN3; PTPN4A; PTPN14; PTPN22; DUSP23B; DUSP18; PTPN7; MTMR8; PTPMT1
    protein tyrosine/serine/threonine phosphatase activity DUSP18; DUSP4; TENC1; CDC14AB; DUSP23; RNGTT; DUSP16; DUSP23B; PTEN; PTPRQ

    DUSP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP10.

    MAPK9; Mapk14; SNX2; FN1; HTT; RPS11; FHL2; MAPK14; SLX1A; CMTM6

    Manzano, RG; Martinez-Navarro, EM; et al. Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers. INTERNATIONAL JOURNAL OF ONCOLOGY 45:2250-2266(2014).
    Ryynanen, J; Neme, A; et al. Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. MOLECULAR NUTRITION & FOOD RESEARCH 58:2036-2045(2014).

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