dusp2
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  • Official Full Name
  • dual specificity phosphatase 2
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
  • Synonyms
  • DUSP2; dual specificity phosphatase 2; dual specificity protein phosphatase 2; PAC 1; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC1; Serine/threonine specific protein phosphatase; OTTHUMP00000161013; dual-specificity phosphatase 2; dual specificity protein phosphatase PAC-1; PAC-1
Cat.#:DUSP2-101HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DUSP2, GST-tagged
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Cat.#:DUSP2-45HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human DUSP2 protein, His-tagged
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Cat.#:DUSP2-4883MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DUSP2 Protein
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Cat.#:DUSP2-898ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP2
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Involved Pathway

DUSP2 involved in several pathways and played different roles in them. We selected most pathways DUSP2 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
SPTBN2; NRG2A; WDR83; SPRED2; CRK; SPTB; CSF2RA; NRG4; CSF2RB; FRS2B
Axon guidance
CSNK2A1; SHB; FYN; PPP3CA; PAK6; ARPC2; FGF8B; EFNB2A; ST8SIA2; PPP3CC
Cytokine Signaling in Immune system
TNFSF13B; HAVCR2; KPNA5; IFIT8; TRIM45; DUSP10; IL1RN; IRF2; NOD1; NRG3
DAP12 interactions
MOV10; AGO1; SPRED3; DUSP5; HBEGF; FGF18B; AGO2; TREM1; SIGLEC15; CSF2RB
DAP12 signaling
JAK1; SPRED3; FGF18B; JAK3; CSF2RB; IL17RD; FRS2B; RASGEF1A; MARK3; SPTBN2
Developmental Biology
DPYSL5A; LAMTOR2; COL6A3; LGI1B; SCN9A; ACTR2; DUSP9; CAP2; FRS2B; EZRA
Downstream signal transduction
RASGEF1A; LAMTOR2; DUSP9; THEM4; MOV10; FGF10B; IL17RD; SPNA1; AGO1; TRAT1
Downstream signaling of activated FGFR1
PEA15A; DUSP9; PTPRA; IL17RD; SPTB; PHB; SPRED1; RASGRP4; MARK3; SPNA1

Protein Function

DUSP2 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, mitogen-activated protein kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP2 itself. We selected most functions DUSP2 had, and list some proteins which have the same functions with DUSP2. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein DUSP16; DUSP14; SGPP2; PTPRQ; DUSP18; DUSP2; DUSP7; DUSP21; NT5DC3; DUSP8A
Function mitogen-activated protein kinase binding
Related Protein NBR1; MAPKAPK2; PLCB4; ACE; MAPKAPK5; PTPRJ; EP300; ABL1; MAPK7; TNIP1
Function protein binding
Related Protein KAT2B; PPP1R9B; KCNJ5; DTNB; YY1AP1; NLGN3; NTF3; TOPORS; RAB18; HDGF2
Function protein tyrosine phosphatase activity
Related Protein PTPN7; PTENA; DUSP14; MTMR2; EYA2; PTPN23; PTENB; DUSP23A; MTMR7; PTPRR
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein DUSP23A; DUSP11; CTDSPL2B; SACM1LB; PTP4A2B; DUSP14; PTPMT1; DUSP23; DUSP19A; PTPDC1
Function protein tyrosine/threonine phosphatase activity
Related Protein DUSP19; PXYLP1; NT5DC3; SGPP2; TENC1; DUSP2; DUSP4; PTPRQ; CTDSPL2A; CTDSPL2B

Interacting Protein

DUSP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP2.
MAPK3; MAPK1