DUSP3 Protein, dual specificity phosphatase 3

DUSP3

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DUSP3

Official Full Name dual specificity phosphatase 3
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Synonyms DUSP3; dual specificity phosphatase 3; vaccinia virus phosphatase VH1 related , VHR; dual specificity protein phosphatase 3; vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; dual specificity protein phosphatase VHR; serine/threonin
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP3-001HCL Recombinant Human DUSP3 cell lysate Insect Cell N/A
    Human DUSP3-1207H Recombinant Human Dual Specificity Phosphatase 3 E.coli N/A
    Human DUSP3-2492H Recombinant Human Dual Specificity Phosphatase 3, His-tagged E.coli His
    Human DUSP3-26911TH Recombinant Human DUSP3, His-tagged E.coli His
    Human DUSP3-2781H Recombinant Human DUSP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DUSP3-28377TH Recombinant Human DUSP3 E.coli N/A
    Human DUSP3-2939H Recombinant Human DUSP3 Protein, GST-tagged Wheat Germ GST
    Human DUSP3-3807H Recombinant Human DUSP3, His & GST tagged Insect Cell His/GST
    Human DUSP3-473H Recombinant Human DUSP3, Gly & Pro tagged Insect Cell His
    Rhesus Macaque DUSP3-1355R Recombinant Rhesus monkey DUSP3 Protein, His-tagged Mammalian Cell His

    DUSP3 involved in several pathways and played different roles in them. We selected most pathways DUSP3 participated on our site, such as Activated TLR4 signalling, ERK/MAPK targets, ERKs are inactivated, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling SIGIRR; ALCAMB; TAB1; MAPKAPK2B; ATF2; APPB; DUSP6; APPA; CREB1; TICAM1
    ERK/MAPK targets DUSP3; DUSP3B
    ERKs are inactivated DUSP3B; DUSP3
    Immune System DEFB116; LRSAM1; SEC24A; ASB6; PPAPDC1B; POLR3H; ABI1; CR1; ASB8; TREML4
    Innate Immune System BTR09; DEFA3; MASP2; TREM1; DDX41; TLR10; C1rb; TANK; NLRP4B; RCA2.1
    MAP kinase activation in TLR cascade DUSP3B; NOD1; TNIP2; DUSP3
    MAPK signaling pathway PRKCG; JIP1; TRAF2; NLK1; MAP3K13; RASGRF2B; RPS6KA4; GNA12A; HSC70; RELA
    MAPK targets/ Nuclear events mediated by MAP kinases DUSP3; DUSP3B

    DUSP3 has several biochemical functions, for example, MAP kinase phosphatase activity, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP3 itself. We selected most functions DUSP3 had, and list some proteins which have the same functions with DUSP3. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase phosphatase activity DUSP10; DUSP3B; DUSP3
    protein kinase binding TP53; CDC42; CCNA2; PIWIL1; NGFRAP1; CDK5; FOXO3; CDC25B; LAX1; PRKAB1
    protein tyrosine phosphatase activity PTPRU; PTPRO; RNGTT; CDC25B; PTPN7; CDC14A; PTPRF; LRP8; DUSP23B; PTPN22
    protein tyrosine/serine/threonine phosphatase activity DUSP3; PXYLP1; SACM1LA; EYA3; SGPP2; PTENB; RNGTT; DUSP19A; DUSP2; DUSP18

    DUSP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP3.

    MAPK3; MAPK1; MCC; HLA-B; CASK; BNIP3L; NEUROD1; pi3p

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