dusp7
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  • Official Full Name
  • dual specificity phosphatase 7
  • Background
  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK;(mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with;specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain;and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic;processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et;al., 2009 (PubMed 19228121)).
  • Synonyms
  • DUSP7; dual specificity phosphatase 7; dual specificity protein phosphatase 7; MKP X; PYST2; dual-specificity phosphatase-7; dual specificity protein phosphatase PYST2; MKPX; DKFZp586F2224
Cat.#:DUSP7-2946HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP7 Protein, GST-tagged
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Cat.#:DUSP7-10163ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP7
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Cat.#:DUSP7-516HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP7 cell lysate
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Involved Pathway

DUSP7 involved in several pathways and played different roles in them. We selected most pathways DUSP7 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
NRG3; CSF2; EGFR; SPNA1; FGF20A; KLB; DUSP10; FRS3; JAK1; LAMTOR2
Activated TLR4 signalling
DUSP6; TANK; MAPKAPK2B; DUSP3; SAA1; IRAK3; MAP3K8; CREB1B; RIPK3; PELI1
Axon guidance
RASA1; UNC5C; ABLIM1; EPHB4A; TRIO; COL4A4; HBEGF; LRRC4C; KRAS; EFNA4
Cytokine Signaling in Immune system
RASGRP4; PTPRA; EDA; TRIM8; MX2; PELI3; SPRED2; FGF20A; DUSP4; EGR1
DAP12 interactions
GRAP2A; LCP2A; PTPRA; SPTBN1; SPTA1; PEA15; DUSP7; CD300E; PEBP1; FGF8B
DAP12 signaling
KBTBD7; MARK3; DUSP5; GRAP2B; FGF10B; CNKSR1; DUSP9; PEA15; RASGRP1; DUSP6
Developmental Biology
MED16; COL4A3; SHB; PLXNC1; SCN4A; CDK19; CEBPB; DCX; LGI1; SIAH2
Downstream signal transduction
SPNA1; DUSP7; AGO3; RASGEF1A; SPTB; LAMTOR2; SPTBN1; DUSP10; CNKSR1; DUSP9

Protein Function

DUSP7 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP7 itself. We selected most functions DUSP7 had, and list some proteins which have the same functions with DUSP7. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein TENC1; PTPRQ; DUSP16; SACM1LA; DUSP8A; CTDSPL2B; CTDSPL2A; DUSP9; DUSP18; DUSP21
Function protein binding
Related Protein CCR5; MPPED2; CSF2RB; ZNF180; BCL3; RHBDD1; MEOX2; RXRB; HER11; TSHR
Function protein tyrosine phosphatase activity
Related Protein SSH2; PTPN2; DUSP2; DUSP19; DUSP8A; PTPRR; PTPN23; PTP4A2B; RNGTT; DUSP5

Interacting Protein

DUSP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP7.
GHR; SPOP; MAPK1; MAPK14; ubiq_human; UBA1; UBE2D2

DUSP7 Related Articles

Carlos, AR; Escandell, JM; et al. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. NATURE COMMUNICATIONS 4:-(2013).
Klorin, G; Rozenblum, E; et al. Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines. CANCER GENETICS 206:191-205(2013).