Recombinant Human DUSP7 Protein, GST-tagged

• Cat.No.: DUSP7-2946H
• Product Overview: Human DUSP7 full-length ORF ( AAH19107.1, 1 a.a. - 320 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 60.94 kDa
• AA Sequence: MLRRLRKGNLPIRSIIPNHADKERF ATRCKAATVLLYDEATAEWQPEPGA PASVLGLLLQKLRDDGCQAYYLQGG FNKFQTEYSEHCETNVDSSSSPSSS PPTSVLGLGGLRISSDCSDGESDRE LPSSATESDGSPVPSSQPAFPVQIL PYLYLGCAKDSTNLDVLGKYGIKYI LNVTPNLPNAFEHGGEFTYKQIPIS DHWSQNLSQFFPEAISFIDEARSKK CGVLVHCLAGISRSVTVTVAYLMQK MNLSLNDAYDFVKRKKSNISPNFNF MGQLLDFERTLGLSSPCDNHASSEQ LYFSTPTNHNLFPLNTLEST
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DUSP7 dual specificity phosphatase 7 [ Homo sapiens ]
• Official Symbol: DUSP7
• Synonyms: DUSP7; dual specificity phosphatase 7; dual specificity protein phosphatase 7; MKP X; PYST2; dual-specificity phosphatase-7; dual specificity protein phosphatase PYST2; MKPX; DKFZp586F2224
• Gene ID: 1849
• mRNA Refseq: NM_001947
• Protein Refseq: NP_001938
• MIM: 602749
• UniProt ID: Q16829