dusp9
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  • Official Full Name
  • dual specificity phosphatase 9
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
  • Synonyms
  • DUSP9; dual specificity phosphatase 9; dual specificity protein phosphatase 9; map kinase phosphatase 4; MKP 4; MKP4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4; MKP-4
Cat.#:DUSP9-2948HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP9 Protein, GST-tagged
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Cat.#:DUSP9-12220HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP9, His-tagged
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Cat.#:DUSP9-1357RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DUSP9 Protein, His-tagged
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Cat.#:DUSP9-6769HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DUSP9 293 Cell Lysate
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Involved Pathway

DUSP9 involved in several pathways and played different roles in them. We selected most pathways DUSP9 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
HBEGF; EGFR; FRS2B; FRS2A; FGF8B; PAQR3A; NETO2; SPNA1; PSMD14; RASGEF1A
Axon guidance
LRRC4; CLASP1; COL6A3; RHOGA; PLXNA1; DLG3; NFATC3; EPHA3; NRP1A; JAK3
Cytokine Signaling in Immune system
GBP4; TRIM6; NRG3; TRIM2; IFIT11; TRIM38; IRF2; FRS3; HLA-DQB2; TRIM3
DAP12 interactions
TRAT1; SPNA2; THEM4; FRS2; CSF2RA; AGO2; TREM1; SPTBN1; AGO1; FRS2A
DAP12 signaling
PEA15A; DUSP4; HBEGF; SPRED2; AGO2; FGF8B; SPTA1; CNKSR1; AGO3; FRS2A
Developmental Biology
TRPC4; CEBPA; EFNA1B; CFL1; LEFTY1; EFNB2; PEA15A; EPHB3A; TCF4; RGMA
Downstream signal transduction
PEA15A; PAQR3A; MOV10; JAK1; AGO2; SPRED1; PTPRA; AGO3; SPRED2; FGF20A
Downstream signaling of activated FGFR1
CNKSR1; PEA15; IL17RD; WDR83; SPRED2; PHB; DUSP9; AGO2; SPRED3; KBTBD7

Protein Function

DUSP9 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP9 itself. We selected most functions DUSP9 had, and list some proteins which have the same functions with DUSP9. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein CTDSPL2A; SACM1L; DUSP2; NT5DC3; PXYLP1; SACM1LB; DUSP14; PTPRQ; DUSP9; SACM1LA
Function phosphoprotein phosphatase activity
Related Protein PPP1CC; DUSP9; PTPN11B; PPM1AA; PDXP; PTPRZ1; MTM1; CDC14AA; DUSP22A; PPM1DB
Function protein binding
Related Protein PLXNB2; MAP3K11; DNMT3L; STAT2; CENPH; EGLN1; LRPPRC; LCE1B; PDCD6IP; RBPJ
Function protein tyrosine phosphatase activity
Related Protein PTPRG; PTPRZ1; MTMR7B; PTPN4A; PTENB; SSH2; PTPN14; SSH1; PTPRU; PTPRNA
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein SSH3; TPTE; CDC14AA; DUSP3B; PTPDC1; DUSP8A; SGPP2; DUSP22; SACM1L; SACM1LB

Interacting Protein

DUSP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP9.
Mapk14; MAPK14; MAPK3; MAPK1; CDK4; GSK3B; Mapk1; Mapk3; STK4; MAPK11