Recombinant Human DUSP9, His-tagged

• Cat.No.: DUSP9-12220H
• Product Overview: Recombinant Human DUSP9 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-381a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: DUSP9 dual specificity phosphatase 9 [ Homo sapiens ]
• Official Symbol: DUSP9
• Synonyms: DUSP9; dual specificity phosphatase 9; dual specificity protein phosphatase 9; map kinase phosphatase 4; MKP 4; MKP4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4; MKP-4
• Gene ID: 1852
• mRNA Refseq: NM_001395
• Protein Refseq: NP_001386
• MIM: 300134
• UniProt ID: Q99956
• Chromosome Location: Xq28
• Pathway: MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem
• Function: MAP kinase tyrosine/serine/threonine phosphatase activity; hydrolase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity