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DYRK4

Official Full Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Overview

Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al.,;2005 (PubMed 15607427)).
Synonyms

DYRK4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dual specificity tyrosine-phosphorylation-regulated kinase 4; Dual specificity tyrosine phosphorylation regulated kinase 4; EC 2.7.12.1; OTTHUMP00000238290; OTTHUMP00000238291; OTTHUMP00000238292;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Insect (sf21)
Insect Cell
Wheat Germ

Tag

DYKDDDDK
Flag
GST
His
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DYRK4-12240H	Recombinant Human DYRK4, His-tagged	E.coli	His	104-400a.a.	$319 / 25ug
Human	DYRK4-2992H	Active Recombinant Human DYRK4 Protein, Flag-tagged	Insect Cell	Flag		Inquiry
Human	DYRK4-2993H	Recombinant Human DYRK4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DYRK4-6749HCL	Recombinant Human DYRK4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DYRK4-4646HF	Active Recombinant Full Length Human DYRK4 Protein, DYKDDDDK-tagged	Insect (sf21)	DYKDDDDK	1-520(end)	Inquiry
Human	DYRK4-0845H	Recombinant Human DYRK4 Protein (M1-V520), Tag Free	Insect Cell	No tag	M1-V520	Inquiry
Human	DYRK4-4093HF	Recombinant Full Length Human DYRK4 Protein, GST-tagged	In Vitro Cell Free System	GST	520 amino acids	Inquiry
Human	DYRK4-0846H	Recombinant Human DYRK4 Protein (M1-V520), His/Flag tagged	Insect Cell	His/Flag	M1-V520	Inquiry

Involved Pathway
Protein Function
Interacting Protein
DYRK4 Related Articles

DYRK4 involved in several pathways and played different roles in them. We selected most pathways DYRK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

DYRK4 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK4 itself. We selected most functions DYRK4 had, and list some proteins which have the same functions with DYRK4. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	EIF4A3;ACLYA;UCK2B;ATP1A1A.2;ADCY3;TNK2B;NAIP7;PIP5K1B;PKN2
metal ion binding	FHL1B;ACY3;CA4A;CYP2N13;KAT5;RARGB;BCL11BA;HRG;GMIP
protein binding	DTNBP1;Icosl;DCP1A;SGOL2;MED14;E2F1;AGTR2;HIST2H4A;ETV1
protein serine/threonine kinase activity	MAPK12A;TSSK6;SNRKB;TTBK1;DAPK2;MAPK14B;cka1;PLK4;MYO3B
protein serine/threonine/tyrosine kinase activity	TESK2;TESK1;TNK2;CLK2;MAP2K2;CLK1;DYRK1A;TTK;DYRK4
protein tyrosine kinase activity	FGFR1A;KITA;Fert2;HCK;DYRK4;MAP3K9;JAK2A;EPHB2;EPHB3A

DYRK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK4.

DYRK2; MID1; HSP90AA1; HSP90AB1; PPP1CC; CUL3; CDIPT; ATP1A1; USP11; RCN1; YME1L1; WDR33; TECR

Schmitt, C; Miralinaghi, P; et al. Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4. ACS MEDICINAL CHEMISTRY LETTERS 5:963-967(2014).

Barallobre, MJ; Perier, C; et al. DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. CELL DEATH & DISEASE 5:-(2014).