e2f5
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  • Official Full Name
  • E2F transcription factor 5, p130-binding
  • Background
  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.
  • Synonyms
  • E2F5; E2F transcription factor 5, p130-binding; transcription factor E2F5; E2F 5; E2F transcription factor 5; E2F transcription factor 5 p130 binding; p130 binding; OTTHUMP00000227505; OTTHUMP00000227506; OTTHUMP00000227507; OTTHUMP00000227508; E2F-5
Cat.#:E2F5-3009HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F5 Protein, GST-tagged
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Cat.#:E2F5-935HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human E2F5 Protein, MYC/DDK-tagged
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Cat.#:E2F5-007HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F5 Protein, His-tagged
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Cat.#:E2F5-4934MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E2F5 Protein
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Cat.#:E2F5-2631CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken E2F5
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Cat.#:E2F5-11651ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish E2F5
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Cat.#:E2F5-7826ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish E2F5
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Involved Pathway

E2F5 involved in several pathways and played different roles in them. We selected most pathways E2F5 participated on our site, such as Cell cycle, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
CDK4; CDC26; YWHABA; CSNK2B; PLK1; CDC25A; CLASP1A; YWHAE1; NIPBLB; ENSA
TGF-beta signaling pathway
INHBAB; TNF; ID3; RHOAC; ACVR2B; BMPR1BB; BAMBIB; BMP5; BMPR1BA; BMP6

Protein Function

E2F5 has several biochemical functions, for example, DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F5 itself. We selected most functions E2F5 had, and list some proteins which have the same functions with E2F5. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MCM6L; LHX1B; EVX2; ADNP2; SFPI1; HOXD4A; KLF5; PLAGL1; SRFB; KDM1B
Function protein binding
Related Protein H3F3C; MED10; TUBA1A; DUSP9; TMEM183A; TJP1; KLRD1; ZEB1; UPP2; XRCC3
Function sequence-specific DNA binding
Related Protein NKX2.4B; ZBTB4; LMX1A; ARX; FOXB1B; NR2F6B; LHX8A; ZNF205; NKX2-6; BSX
Function transcription factor activity, sequence-specific DNA binding
Related Protein ELK1; TFDP2; TCF19; ZKSCAN5; PIP4K2AA; HSFX1; HOXC4A; EF1; Trl; RFX8
Function transcription factor binding
Related Protein FOXF2; STK36; HES4; TBL1X; BRD7; PPP1R13BB; HEYL; UBN1; CDK9; PELP1

Interacting Protein

E2F5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F5 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F5.
Tfdp2; Arid1a; Arid1b