EIF1AX Protein, eukaryotic translation initiation factor 1A, X chromosome

EIF1AX

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EIF1AX

Official Full Name eukaryotic translation initiation factor 1A, X chromosome
Background Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene. Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex.
Synonyms EIF1AX; eukaryotic translation initiation factor 1A, X chromosome; EIF1A; EIF4C
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF1AX-12345H Recombinant Human EIF1AX, GST-tagged E.coli GST
    Human EIF1AX-2817H Recombinant Human EIF1AX, His-tagged E.coli His
    Human EIF1AX-3141H Recombinant Human EIF1AX Protein, GST-tagged Wheat Germ GST
    Human EIF1AX-381H Recombinant Human EIF1AX Protein, His-tagged E.coli His
    Human EIF1AX-6677HCL Recombinant Human EIF1AX 293 Cell Lysate HEK293 N/A
    Rhesus Macaque EIF1AX-1411R Recombinant Rhesus monkey EIF1AX Protein, His-tagged Mammalian Cell His

    EIF1AX involved in several pathways and played different roles in them. We selected most pathways EIF1AX participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF1AX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4G1; EIF4EB; EIF4B; EIF3K; EIF4A1; FAUB; EIF4EBP1; EIF2S1; EIF4H; EIF4E
    Cap-dependent Translation Initiation EIF4A2; EIF5; EIF2S1A; EIF3K; FAUB; RPL35; EIF4H; EIF1AXA; EIF2B1; EIF1AX
    Eukaryotic Translation Initiation EIF1AX; EIF2S1A; EIF4G1; EIF2B1; RPL35; EIF2S1; EIF3K; EIF4A1; EIF5; FAUB
    Formation of a pool of free 40S subunits RPL35; EIF3K; EIF1AXA; FAUB; EIF1AX
    Formation of the ternary complex, and subsequently, the 43S complex EIF2S1A; EIF2S1; EIF3K; EIF2S3; EIF1AX; FAUB; EIF1AXA
    GTP hydrolysis and joining of the 60S ribosomal subunit EIF1AX; EIF4H; FAUB; EIF3K; EIF4B; EIF5; EIF2S3; EIF2S1A; EIF1AXA; EIF2S1
    Gene Expression ZNF473; ZNF10; ASZ1; TET2; ZNF157; RPP40; GPR19; MBD3; METTL1; ZNF287
    L13a-mediated translational silencing of Ceruloplasmin expression EIF2S1A; EIF2S3; EIF3K; EIF1AX; EIF1AXA; FAUB; EIF4H

    EIF1AX has several biochemical functions, for example, poly(A) RNA binding, protein binding, translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF1AX itself. We selected most functions EIF1AX had, and list some proteins which have the same functions with EIF1AX. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding MRPL10; BCCIP; ZCCHC7; SRP54A; ZCCHC8; MBNL3; RPUSD3; DDX39A; NPM1; CANX
    protein binding FUCA2; FANCG; GEM; FAF2; KCNQ5; BCL10; ISYNA1; MON1B; NDUFB9; TUBGCP2
    translation factor activity, RNA binding EIF2S2; EEF2K; GTF2H2; CPEB1A; EIF1; SOX11; EIF4H; CPEB2; EIF4G1; EIF4G3
    translation initiation factor activity EIF3S6IP; EIF4H; EIF3S10; EIF1AXA; EIF2S2; MTIF3; EIF4EA; EIF2D; EIF4A1B; EIF1B

    EIF1AX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF1AX here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF1AX.

    IPO13; RAN; EIF5; EIF1B

    Yu, CP; Luo, CC; et al. Molecular network including eIF1AX, RPS7, and 14-3-3 gamma regulates protein translation and cell proliferation in bovine mammary epithelial cells. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 564:142-155(2014).
    Agrawal, N; Akbani, R; et al. Integrated Genomic Characterization of Papillary Thyroid Carcinoma. CELL 159:676-690(2014).

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