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ENPP1

  • Official Full Name

    ectonucleotide pyrophosphatase/phosphodiesterase 1

  • Overview

    Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-
  • Synonyms

    ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1; M6S1, NPPS, PDNP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; PC 1; PCA1; E-NPP 1; Ly-41 antigen; alkaline phosphodiesterase 1; plasma-cell membrane glycoprotein 1; plasma-c;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENPP1-1414H Recombinant Human ENPP1 protein, His-tagged E.coli His Asp362~Trp518 (Accession # P22413)
Human ENPP1-3320H Recombinant Human ENPP1 Protein Wheat Germ N/A
Human ENPP1-3321H Recombinant Human ENPP1 Protein, GST-tagged Wheat Germ GST
Human ENPP1-6595HCL Recombinant Human ENPP1 293 Cell Lysate HEK293 N/A
Human ENPP1-4318HF Recombinant Full Length Human ENPP1 Protein In Vitro Cell Free System 290 amino acids
Human ENPP1-3365H Recombinant Human ENPP1 protein, Myc/DDK-tagged HEK293 Myc/DDK
Human ENPP1-1024H Recombinant Human ENPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ENPP1-1235H Recombinant Human ENPP1 protein, His-tagged HEK293 His Lys98-Asp925
Human ENPP1-4319HF Recombinant Full Length Human ENPP1 Protein, GST-tagged In Vitro Cell Free System GST 873 amino acids
Mouse Enpp1-1415M Recombinant Mouse Enpp1 protein, His & GST-tagged E.coli His/GST Gly568~Asp789
Mouse Enpp1-78M Recombinant Mouse Enpp1 protein, Myc/DDK-tagged HEK293 Myc/DDK
Mouse Enpp1-2831M Recombinant Mouse Enpp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ENPP1-2103R Recombinant Rat ENPP1 Protein Mammalian Cell His
Rat Enpp1-1416R Recombinant Rat Enpp1 protein, His & GST-tagged E.coli His/GST Glu568~Ile793 (Accession # Q924C3)
Rat ENPP1-1760R Recombinant Rat ENPP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ENPP1-1760R-B Recombinant Rat ENPP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ENPP1-3278Z Recombinant Zebrafish ENPP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ENPP1 Related Articles
  • ENPP1 Related Research Area

ENPP1 involved in several pathways and played different roles in them. We selected most pathways ENPP1 participated on our site, such as Purine metabolism, Starch and sucrose metabolism, Nicotinate and nicotinamide metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR1B;NUDT5;GUK1;PKMA;POLR2F;NPR2;POLR2GL;PGM1;ADCY2B
Starch and sucrose metabolismAGL;HK2;TREH;GPI1;UGT1A7;UGT5G1;GYS2;GPIB;AMY2A5
Nicotinate and nicotinamide metabolismAOX3L1;NT5C1B-RDH14;NMNAT1;NMNAT3;NT5C;NT5C3A;AOX4;NUDT12;NT5C3B
Pantothenate and CoA biosynthesisCOASY;BCAT2;DPYD;PPCDC;VNN1;PANK2;DPYS;UPB1;AASDHPPT
Metabolic pathwaysST3GAL2;NME4;AKR1B1;UQCRB;HADHB;CYP2C37;UGT1A1;ALOX5;NDUFB6

ENPP1 has several biochemical functions, for example, 3-phosphoadenosine 5-phosphosulfate binding, ATP binding, NADH pyrophosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENPP1 itself. We selected most functions ENPP1 had, and list some proteins which have the same functions with ENPP1. You can find most of the proteins on our site.

Function Related Protein
3-phosphoadenosine 5-phosphosulfate bindingHS3ST5;CHST15;GAL3ST4;ENPP1;CHST12
ATP bindingERN2;ACSL1;PAPD4;RARS;UBE2C;UBE2J2;CARS;AMHR2;KIF2A
NADH pyrophosphatase activityENPP1;NUDT12
calcium ion bindingNOTCH3;FREM1A;PCDH2AB9;STIM1;PLCB3;CLGN;MYL13;RASGRP4;NKD1
insulin receptor bindingIGF1R;SNX2;IGF1;DOK4;DOK3;INS1;FRS2B;DOK6;IRS2
nucleic acid bindingWT1B;ZFP828;ZFR;ZNF45L;RBM14A;ZFP710;ZFP385C;TBK1;ZFP13
nucleoside-triphosphate diphosphatase activityENPP1;DCTPP1
nucleotide diphosphatase activityENPP1;ENPP2
phosphodiesterase I activityENPP1;ENPP2;APEX1;FAN1
polysaccharide bindingENDOU;VTNA;TINAG;CLEC4G;SUSD2;AGL;C8orf84;MBL1;ENPP1
protein bindingRBM17;MYCBP;GDPD5;PELI2;ARL16;EXO1;RHOBTB3;RAB9A;RNF2
protein homodimerization activityHNF1B;CD200;CHMP3;EFR3A;FAP;HPGD;CACYBP;CHMP1A;ADAM10
scavenger receptor activityCXCL16;LGALS3BPB;ACKR4;LOXL4;C8orf84;PRG4A;VTN;CD5L;ENPP1
zinc ion bindingZDHHC11;RNF166;NR4A2;APOBEC3C;ANPEPB;YAF2;NR5A1;LIMCH1B;MSL2

ENPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENPP1.

INSR; Dlg4; SQSTM1

Li, LY; Yin, Q; et al. Hydrolysis of 2 ' 3 '-cGAMP by ENPP1 and design of nonhydrolyzable analogs. NATURE CHEMICAL BIOLOGY 11:235-235(2015).
Ito, N; Wijenayaka, AR; et al. Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:208-218(2015).
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