eps8
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  • Official Full Name
  • epidermal growth factor receptor pathway substrate 8
  • Background
  • This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms
  • EPS8; epidermal growth factor receptor pathway substrate 8; epidermal growth factor receptor kinase substrate 8
Cat.#:EPS8-3426HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPS8 Protein, GST-tagged
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Cat.#:EPS8-12506HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPS8, GST-tagged
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Cat.#:EPS8-467HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EPS8
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Cat.#:EPS8-1488RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EPS8 Protein, His-tagged
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Cat.#:EPS8-10582ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EPS8
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Cat.#:EPS8-6576HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EPS8 293 Cell Lysate
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Involved Pathway

EPS8 involved in several pathways and played different roles in them. We selected most pathways EPS8 participated on our site, such as CDC42 signaling events, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPS8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CDC42 signaling events
ARPC1B; PAK4; ARPC5; EPS8; ARPC4; ARPC3; TNK2; CDC42BPA; ACTR3; CFL1
EGFR1 Signaling Pathway
ZPR1; TNIP1; KLF11; APPL2; STXBP1A; SH3BGRL; PLSCR1; CEACAM1; GRB14; ERRFI1
ErbB1 downstream signaling
CHN2; ACTR3; ABI1; WASF2; NCKAP1; EGR1; ACTR2; BAIAP2; ARF4; MAP3K2
Regulation of RAC1 activity
PREX2; ABR; RAP1GDS1; CHN1; DEF6; ARHGAP1; ARHGAP17; EPS8; ARHGEF25; RALBP1

Protein Function

EPS8 has several biochemical functions, for example, Rac GTPase binding, SH3/SH2 adaptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPS8 itself. We selected most functions EPS8 had, and list some proteins which have the same functions with EPS8. You can find most of the proteins on our site.
Function
Related Protein
Function Rac GTPase binding
Related Protein DOCK4; ARHGAP4A; PAK1; MAP3K11; RALBP1; PAK2; HACE1; ITPKA; FLNA; RCC2
Function SH3/SH2 adaptor activity
Related Protein SH2B2; HSH2D; RUSC1; LASP1; ITSN2; GRB10; STAM; SH3BGRL; CRK; EPS8
Function actin binding
Related Protein GSNA; CAPGA; EPS8L1; CORO7; DAG1; MICAL2B; DIAPH1; TNNT2A; MYBPC2; LRRC10
Function protein binding
Related Protein PRDM16; RHBDD1; NPM3; NUP62; ATP2A2; FAM158A; FKBP3; MINK1; MYO5B; CASP6

Interacting Protein

EPS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPS8.
BAIAP2; HNRNPC; GRB2; RUNX1T1; GOLGA8DP

EPS8 Related Articles

Xiao, X; Mruk, DD; et al. Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. HUMAN REPRODUCTION 29:1279-1291(2014).
Cheng, CY; Mruk, DD; et al. The Blood-Testis Barrier and Its Implications for Male Contraception. PHARMACOLOGICAL REVIEWS 64:16-64(2012).