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Official Full Name epidermal growth factor receptor pathway substrate 8
Background This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms EPS8; epidermal growth factor receptor pathway substrate 8; epidermal growth factor receptor kinase substrate 8
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EPS8-4513H Recombinant Human EPS8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Eps8-966M Recombinant Mouse Eps8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EPS8-12506H Recombinant Human EPS8, GST-tagged E.coli GST
    Human EPS8-3426H Recombinant Human EPS8 Protein, GST-tagged Wheat Germ GST
    Human EPS8-467H Recombinant Human EPS8 Mammalian Cell His
    Human EPS8-6576HCL Recombinant Human EPS8 293 Cell Lysate HEK293 N/A
    Rhesus Macaque EPS8-1488R Recombinant Rhesus monkey EPS8 Protein, His-tagged Mammalian Cell His
    Zebrafish EPS8-10582Z Recombinant Zebrafish EPS8 Mammalian Cell His

    EPS8 involved in several pathways and played different roles in them. We selected most pathways EPS8 participated on our site, such as CDC42 signaling events, EGFR1 Signaling Pathway, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CDC42 signaling events ACTR3; ARPC3; PAK4; CFL1; BAIAP2; ARPC5; TNK2; IQGAP3; ARPC1B; EPS8
    ErbB1 downstream signaling EGR1; ACTR3; CHN2; MAP3K2; ARF4; EPS8; WASF2; ABI1; ACTR2; NCKAP1
    Regulation of RAC1 activity PREX2; EPS8; CHN2; ARHGAP1; DEF6; DOCK6; ARHGAP17; ABR; ARHGAP9; SPATA13

    EPS8 has several biochemical functions, for example, Rac GTPase binding, SH3/SH2 adaptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPS8 itself. We selected most functions EPS8 had, and list some proteins which have the same functions with EPS8. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding RCC2; CDKL5; SRGAP2A; PAK6; ARHGAP4; SOD1; PAK2; PAK1; NOXA1; PAK7
    SH3/SH2 adaptor activity NCK1; CNTNAP1; CRK; HSH2D; STAP1; SHB; ARHGAP4; LAT; CHN1; ARHGAP1
    actin binding SSH1; CXCR4; HIP1RB; GCET2; VCL; MICAL2B; TMSB; FSCN2B; CFL2L; TWF1B
    protein binding HBA1; HOXB6; C12orf43; RCOR2; MED6; TDP1; PSMB3; ZNF239; KHDRBS2; RAB14

    EPS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPS8.


    Xiao, X; Mruk, DD; et al. Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. HUMAN REPRODUCTION 29:1279-1291(2014).
    Cheng, CY; Mruk, DD; et al. The Blood-Testis Barrier and Its Implications for Male Contraception. PHARMACOLOGICAL REVIEWS 64:16-64(2012).

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